Results 41 to 50 of about 62,800 (259)

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. [PDF]

Proceedings of the National Academy of Sciences, 1995
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues.
Schwecke, Torsten, Aparicio, Jesús F., Molnár, István, König, Ariane, Khaw, Lake Ee, Haydock, Stephen F., Oliynyk, Markiyan, Caffrey, Patrick, Cortés, Jesús, Lester, John B., Böhm, Günter A., Staunton, James, Leadlay, Peter F.   +12 more
openaire   +2 more sources

ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. [PDF]

PLoS ONE, 2012
Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens.
Jing Li, Xudong Qu, Xinyi He, Lian Duan, Guojun Wu, Dexi Bi, Zixin Deng, Wen Liu, Hong-Yu Ou   +8 more
doaj   +1 more source

Transcriptional regulation of the novobiocin biosynthetic gene cluster [PDF]

Microbiology, 2009
The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...
Dangel, Volker, Härle, Johannes, Goerke, Christiane, Wolz, Christiane, Gust, Bertolt, Pernodet, Jean-Luc, Heide, Lutz   +6 more
openaire   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Genomic and chemical analyses of 713 marine biofilm-derived bacterial strains

Applied and Environmental Microbiology
Marine biofilms are known as a reservoir of bacterial specialized metabolites, but the majority of these metabolites remain unexplored because most biofilm-associated bacteria have not yet been cultivated or genomically characterized.
Jie Lu, Shen Fan, Jiaoxia Shi, Xiaoli Hu, Wei Ding, Jiejie Hao, Weipeng Zhang   +6 more
doaj   +1 more source

Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism

Frontiers in Microbiology, 2015
The increased number of bacterial genome sequencing projects has generated over the last years a large reservoir of genomic information. In silico analysis of this genomic data has renewed the interest in bacterial bioprospecting for bioactive compounds ...
Tiago eBeites, Tiago eBeites, Marta Vaz Mendes, Marta Vaz Mendes   +3 more
doaj   +1 more source

Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi

Frontiers in Bioengineering and Biotechnology, 2022
Filamentous fungi are highly productive cell factories, many of which are industrial producers of enzymes, organic acids, and secondary metabolites. The increasing number of sequenced fungal genomes revealed a vast and unexplored biosynthetic potential ...
László Mózsik, Riccardo Iacovelli, Roel A. L. Bovenberg, Roel A. L. Bovenberg, Arnold J. M. Driessen   +4 more
doaj   +1 more source

Sequence analysis of porothramycin biosynthetic gene cluster [PDF]

Folia Microbiologica, 2014
The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces albus subsp. albus (ATCC 39897) and sequentially characterized. A 39.7 kb long DNA region contains 27 putative genes, 18 of them revealing high similarity with homologous genes from biosynthetic ...
Najmanova, Lucie, Ulanova, Dana, Jelinkova, Marketa, Kamenik, Zdenek, Kettnerova, Eliska, Koberska, Marketa, Gazak, Radek, Radojevic, Bojana, Janata, Jiri   +8 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source