Visualizing Gene Clusters using Neighborhood Graphs in R [PDF]
, 2008 The visualization of cluster solutions in gene expression data analysis gives practitioners an understanding of the cluster structure of their data and makes it easier to interpret the cluster results.
Leisch, Friedrich, Scharl, Theresa
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Activating cryptic biosynthetic gene clusters via ACTIMOT. [PDF]
Eng MicrobiolThe mainstream strategy of genome mining relies on the homologous activation and heterologous expression of target biosynthetic gene clusters (BGCs).
Bian X.
europepmc +2 more sources
Genome Sequences of Serratia Strains Revealed Common Genes in Both Serratomolides Gene Clusters
Biology, 2020 Serratia strains are ubiquitous microorganisms with the ability to produce serratomolides, such as serrawettins. These extracellular lipopeptides are described as biocides against many bacteria and fungi and may have a nematicidal activity against ...
Catarina Marques-Pereira +2 more
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Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]
PLoS ONE, 2015 The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li +4 more
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Empirically characterized biosynthetic gene clusters used as positive controls.
, 2021 Empirically characterized biosynthetic gene clusters used as positive controls.
Leopold Zehetner (11485502) +5 more
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The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti [PDF]
Frontiers in Microbiology, 2017 Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound.
Rojas Aedo, Juan F. +9 more
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BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov +3 more
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Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola [PDF]
, 2008 Gibberellins (GAs) are tetracyclic diterpenoid phytohormones that were first identified as secondary metabolites of the fungus Fusarium fujikuroi (teleomorph, Gibberella fujikuroi). GAs were also found in the cassava pathogen Sphaceloma manihoticola, but
Hedden, P. +9 more
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Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]
Journal of Industrial Microbiology and Biotechnology, 2019 Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel +2 more
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Marine Drugs, 2015 The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors.
Tao Zhou +5 more
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