Biosynthetic Gene Clusters from Swine Gut Microbiome
Microorganisms, 2023 The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes.
Leli Wang +7 more
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MicrobiologyOpen, 2023 Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus), which together generate a variety of unique secondary metabolites.
Nadim Ahmad +6 more
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The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]
Planta Medica, 2006 Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
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Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]
Molecules, 2016 Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated. In the present study, members of the gene cluster were deleted individually in a Fusarium graminearum strain overexpressing the local ...
Aida Droce +7 more
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Identification, heterologous expression, and characterization of the tolypodiol biosynthetic gene cluster through an integrated approach. [PDF]
, 2023 Cyanobacteria are tremendous producers of biologically active natural products including the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene clusters with compound production in cyanobacteria has lagged behind other ...
Philip , Williams +6 more
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The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces
Communications Chemistry, 2022 The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential.
Doris A. van Bergeijk +8 more
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Plant biosynthetic gene clusters in the context of metabolic evolution [PDF]
, 2022 Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically diverse natural products to interact with their environment. These specialised metabolites typically evolve in limited taxonomic groups presumably in response to ...
Smit, Samuel J., Lichman, Benjamin R.
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Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec. [PDF]
PLoS ONE, 2015 A large and rapidly increasing number of unstudied "orphan" natural product biosynthetic gene clusters are being uncovered in sequenced microbial genomes.
Yasushi Ogasawara +4 more
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Реконструкція філогенії кластерів генів біосинтезу глікопептидів
Фактори експериментальної еволюції організмів, 2017 Aim. In current study we have endeavored to analyze the phylogeny of 18 sequenced glycopeptide biosynthetic gene clusters. Methods. Standard methods of phylogenetic reconstruction were used in this research. Results. We have created sets of conservative
O. S. Yushchuk +3 more
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Mining microbial genomes for new natural products and biosynthetic pathways [PDF]
, 2008 Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
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