Results 21 to 30 of about 62,800 (259)

Biosynthetic gene cluster synteny: Orthologous polyketide synthases in Hypogymnia physodes, Hypogymnia tubulosa, and Parmelia sulcata

MicrobiologyOpen, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus), which together generate a variety of unique secondary metabolites.
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +1 more source

The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]

Planta Medica, 2006
Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
openaire   +2 more sources

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]

Molecules, 2016
Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated. In the present study, members of the gene cluster were deleted individually in a Fusarium graminearum strain overexpressing the local ...
Aida Droce, Wagma Saei, Simon Jørgensen, Reinhard Wimmer, Henriette Giese, Rasmus Wollenberg, Teis Sondergaard, Jens Sørensen   +7 more
openaire   +4 more sources

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

Communications Chemistry, 2022
The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential.
Doris A. van Bergeijk, Somayah S. Elsayed, Chao Du, Isabel Nuñez Santiago, Anna M. Roseboom, Le Zhang, Victor J. Carrión, Herman P. Spaink, Gilles P. van Wezel   +8 more
doaj   +1 more source

Identification of a Biosynthetic Gene Cluster in Rice for Momilactones [PDF]

Journal of Biological Chemistry, 2007
Rice diterpenoid phytoalexins such as momilactones and phytocassanes are produced in suspension-cultured rice cells treated with a chitin oligosaccharide elicitor and in rice leaves irradiated with UV light. The common substrate geranylgeranyl diphosphate is converted into diterpene hydrocarbon precursors via a two-step sequential cyclization and then ...
Kazuhiro, Shimura, Atsushi, Okada, Kazunori, Okada, Yusuke, Jikumaru, Kwang-Wook, Ko, Tomonobu, Toyomasu, Takeshi, Sassa, Morifumi, Hasegawa, Osamu, Kodama, Naoto, Shibuya, Jinichiro, Koga, Hideaki, Nojiri, Hisakazu, Yamane   +12 more
openaire   +2 more sources

Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]

PLoS ONE, 2015
The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li, Zhoujie Xie, Min Wang, Guomin Ai, Yihua Chen   +4 more
doaj   +1 more source

Genome Sequences of Serratia Strains Revealed Common Genes in Both Serratomolides Gene Clusters

Biology, 2020
Serratia strains are ubiquitous microorganisms with the ability to produce serratomolides, such as serrawettins. These extracellular lipopeptides are described as biocides against many bacteria and fungi and may have a nematicidal activity against ...
Catarina Marques-Pereira, Diogo Neves Proença, Paula V. Morais   +2 more
doaj   +1 more source

The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti [PDF]

Frontiers in Microbiology, 2017
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound.
Rojas Aedo, Juan F., Gil Durán, Carlos, Del-Cid, Abdiel, Valdés, Natalia, Álamos, Pamela, Vaca Cerezo, Inmaculada, García Rico, Ramón O., Levicán, Gloria, Tello, Mario, Chávez, Renato   +9 more
openaire   +4 more sources

BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure

Computational and Structural Biotechnology Journal, 2022
Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov, Danil V. Krivonos, Elena N. Ilina, Vladislav V. Babenko   +3 more
doaj   +1 more source

Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]

Journal of Industrial Microbiology and Biotechnology, 2019
Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel, Tuan Anh, Tran, Alessandra S, Eustáquio   +2 more
openaire   +2 more sources