Results 11 to 20 of about 62,800 (259)

Establishing conserved biosynthetic gene clusters of the phylum Myxococcota [PDF]

Applied and Environmental Microbiology
A surge in sequenced myxobacteria catalyzed by advancements in long-read genome and metagenome sequencing has provided sufficient data to scrutinize the conserved biosynthetic gene clusters (BGCs) within the phylum Myxococcota.
Shailaja Khanal Pokharel, Nawal Shehata, Andrew Ahearne, Thomas Knehans, Constance B. Bailey, Paul D. Boudreau, D. Cole Stevens   +6 more
doaj   +6 more sources

Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]

BMC Genomics, 2019
Background Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug ...
Ghofran Othoum, Salim Bougouffa, Ameerah Bokhari, Feras F. Lafi, Takashi Gojobori, Heribert Hirt, Ivan Mijakovic, Vladimir B. Bajic, Magbubah Essack   +8 more
doaj   +6 more sources

In silico analyses of maleidride biosynthetic gene clusters [PDF]

Fungal Biology and Biotechnology, 2022
Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘
Katherine Williams, Kate M. J. de Mattos-Shipley, Christine L. Willis, Andrew M. Bailey   +3 more
doaj   +6 more sources

Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential

Microorganisms, 2019
Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery.
Katherine Gregory, Laura A. Salvador, Shukria Akbar, Barbara I. Adaikpoh, D. Cole Stevens   +4 more
doaj   +3 more sources

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

Frontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide ...
Koen Hoogendoorn, Koen Hoogendoorn, Lena Barra, Cees Waalwijk, Jeroen S. Dickschat, Theo A. J. van der Lee, Marnix H. Medema   +6 more
doaj   +4 more sources

Regulatory and metabolic control of microbial biosynthetic gene clusters [PDF]

Communications Biology
Microbial biosynthetic gene clusters (BGCs) encode diverse bioactive molecules but remain mostly silent under lab conditions, reflecting a balance between regulatory control and the metabolic cost of secondary metabolite production.
Idris Matine, Frederick Clasen, Fernando Garcia Guevara, Miao Guo, Saeed Shoaie   +4 more
doaj   +2 more sources

Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens [PDF]

Fungal Biology and Biotechnology
Background Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a relatively recent addition to the biosynthetic gene cluster (BGC) repertoire of fungi.
Anna Pasinato, Garima Singh
doaj   +2 more sources

Nisin-like biosynthetic gene clusters are widely distributed across microbiomes [PDF]

mBio
Bacteriocins are antimicrobial peptides/proteins that can have narrow or broad inhibitory spectra and remarkable potency against clinically relevant pathogens.
David Hourigan, Des Field, Ellen Murray, Ivan Sugrue, Paula M. O’Connor, Colin Hill, R. Paul Ross   +6 more
doaj   +2 more sources

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

Journal of Fungi, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites. To access this biosynthetic potential for biotechnological applications,
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +1 more source

Biosynthetic Gene Clusters from Swine Gut Microbiome

Microorganisms, 2023
The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes.
Leli Wang, Yiru Zhang, Juan Xu, Chuni Wang, Lanmei Yin, Qiang Tu, Huansheng Yang, Jia Yin   +7 more
doaj   +1 more source