Results 11 to 20 of about 3,203,016 (289)

Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]

open access: yesBMC Genomics, 2019
Background Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug ...
Ghofran Othoum   +8 more
doaj   +9 more sources

In silico analyses of maleidride biosynthetic gene clusters [PDF]

open access: yesFungal Biology and Biotechnology, 2022
Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘
Katherine Williams   +3 more
doaj   +8 more sources

Minimum Information about a Biosynthetic Gene cluster [PDF]

open access: yesNature Chemical Biology, 2015
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters.
Tilmann Weber   +845 more
core   +24 more sources

Multiplexed mobilization and expression of biosynthetic gene clusters

open access: yesNature Communications, 2022
Efficient mobilization and expression of biosynthetic gene clusters (BGCs) into heterologous hosts is needed for microbial natural products discovery. Here, the authors improve the CONKAT-seq strategy by simultaneously capturing the BCGs into a single ...
Vincent Libis   +8 more
doaj   +3 more sources

Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria

open access: yesScientific Reports, 2023
The discovery of novel bioactive compounds produced by microorganisms holds significant potential for the development of therapeutics and agrochemicals.
Wipanee Meesil   +9 more
doaj   +2 more sources

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

open access: yesFrontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide ...
Koen Hoogendoorn   +6 more
doaj   +4 more sources

Establishing conserved biosynthetic gene clusters of the phylum Myxococcota. [PDF]

open access: yesAppl Environ Microbiol
A surge in sequenced myxobacteria catalyzed by advancements in long-read genome and metagenome sequencing has provided sufficient data to scrutinize the conserved biosynthetic gene clusters (BGCs) within the phylum Myxococcota.
Khanal Pokharel S   +6 more
europepmc   +6 more sources

Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi [PDF]

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Filamentous fungi are highly productive cell factories, many of which are industrial producers of enzymes, organic acids, and secondary metabolites. The increasing number of sequenced fungal genomes revealed a vast and unexplored biosynthetic potential ...
László Mózsik   +4 more
doaj   +3 more sources

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

open access: yesJournal of Fungi, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites. To access this biosynthetic potential for biotechnological applications,
Nadim Ahmad   +6 more
doaj   +1 more source

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters [PDF]

open access: yes, 2023
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases,(meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...
Aguilar, C.   +80 more
core   +1 more source

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