Results 91 to 100 of about 3,203,016 (289)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Genomics of NRPS/PKS Biosynthetic Gene Clusters in Cyanobacteria

, 2017
Cyanobacteria are well-known producers of a broad range of natural products of diverse chemical structures. Many of these compounds are the products of non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS) pathways.
Alexandra Calteau, Claire Pancrace, Pancrace, Claire, Calteau, Alexandra, Muriel Gugger, Gugger, Muriel   +5 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Understanding factors responsible for stable maintenance of diverse biosynthetic gene clusters in different organisms

, 2020
Biosynthetic gene clusters for secondary metabolites are typically encoded in operons in microorganisms. Responsible for the synthesis of different natural products, many of which are important medicines with antibiotic, anti-inflammatory, and anti ...
Wenfa Ng (444092)
core   +1 more source

Biosynthetic Gene Cluster for the Polyenoyltetramic Acid α-Lipomycin [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT The gram-positive bacterium Streptomyces aureofaciens Tü117 produces the acyclic polyene antibiotic α-lipomycin. The entire biosynthetic gene cluster ( lip gene cluster) was cloned and characterized.
Bihlmaier, C., Welle, E., Hofmann, C., Welzel, K., Vente, A., Breitling, E., Müller, M., Glaser, S., Bechthold, A.   +8 more
openaire   +3 more sources

Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens. [PDF]

Fungal Biol Biotechnol
Background Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a relatively recent addition to the biosynthetic gene cluster (BGC) repertoire of fungi.
Pasinato A, Singh G.
europepmc   +2 more sources

A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences

Standards in Genomic Sciences, 2018
Microorganisms utilize complex enzymatic pathways to biosynthesize structurally complex and pharmacologically relevant molecules. These pathways are encoded by gene clusters and are found in a diverse set of organisms.
Samuel C. Epstein, Louise K. Charkoudian, Marnix H. Medema   +2 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica [PDF]

Tetrahedron, 2014
The lomaiviticins are a family of cytotoxic marine natural products that have captured the attention of both synthetic and biological chemists due to their intricate molecular scaffolds and potent biological activities. Here we describe the identification of the gene cluster responsible for lomaiviticin biosynthesis in Salinispora pacifica strains DPJ ...
Jeffrey E, Janso, Brad A, Haltli, Alessandra S, Eustáquio, Kerry, Kulowski, Abraham J, Waldman, Li, Zha, Hitomi, Nakamura, Valerie S, Bernan, Haiyin, He, Guy T, Carter, Frank E, Koehn, Emily P, Balskus   +11 more
openaire   +2 more sources

Microbiological and molecular insights on rare Actinobacteria harboring bioactive prospective

Bulletin of the National Research Centre, 2020
Background Actinobacteria is as a group of advanced filamentous bacteria. Rare Actinobacteria are of special interest as they are rarely isolated from the environments. They are a major source of important bioactive compounds.
Dina H. Amin, Nagwa A. Abdallah, Assem Abolmaaty, Sahar Tolba, Elizabeth M. H. Wellington   +4 more
doaj   +1 more source