Results 11 to 20 of about 356,384 (331)

Biosynthetic Gene Clusters from Swine Gut Microbiome

Microorganisms, 2023
The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes.
Leli Wang, Yiru Zhang, Juan Xu, Chuni Wang, Lanmei Yin, Qiang Tu, Huansheng Yang, Jia Yin   +7 more
doaj   +3 more sources

Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]

BMC Genomics, 2019
Background Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug ...
Ghofran Othoum, Salim Bougouffa, Ameerah Bokhari, Feras F. Lafi, Takashi Gojobori, Heribert Hirt, Ivan Mijakovic, Vladimir B. Bajic, Magbubah Essack   +8 more
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In silico analyses of maleidride biosynthetic gene clusters [PDF]

Fungal Biology and Biotechnology, 2022
Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘
Katherine Williams, Kate M. J. de Mattos-Shipley, Christine L. Willis, Andrew M. Bailey   +3 more
doaj   +6 more sources

Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential [PDF]

Microorganisms, 2019
Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery.
Katherine Gregory, Laura A. Salvador, Shukria Akbar, Barbara I. Adaikpoh, D. Cole Stevens   +4 more
doaj   +3 more sources

BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs [PDF]

Genome Research, 2019
Predicting biosynthetic gene clusters (BGCs) is critically important for discovery of antibiotics and other natural products. While BGC prediction from complete genomes is a well-studied problem, predicting BGCs in fragmented genomic assemblies remains ...
Dmitry Meleshko, H. Mohimani, Vittorio Traccana, I. Hajirasouliha, M. Medema, A. Korobeynikov, P. Pevzner   +6 more
semanticscholar   +3 more sources

Minimum Information about a Biosynthetic Gene cluster [PDF]

Nature Chemical Biology, 2015
M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO;Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme(Joint Call OCEAN.2011–2: Marine microbial diversity—new insights into marine ecosystems functioning and its biotechnological potential) under ...
Medema, Marnix H, Kottmann, Renzo, Yilmaz, Yi, Cummings, Matthew, Biggins, John B, Blin, Kai, de Bruijn, Irene, Chooi, Yi, Claesen, Jan, Coates, R Cameron, Cruz-Morales, Pablo, Duddela, Srikanth, Düsterhus, Stephanie, Edwards, Daniel, Fewer, David P, Garg, Neha, Geiger, Christoph, Ju, Juan Pablo, Ju, Jianhua, Greule, Anja, Hadjithomas, Michalis, Haines, Anthony S, Helfrich, Eric J N, Hillwig, Matthew L, Ishida, Keishi, Jones, Jon, Ju, Katrin, Kegler, Carsten, Kim, Hyun Uk, Kötter, Peter, Krug, Daniel, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moore, Marcus, Moss, Nathan, Nützmann, Hans-Wilhelm, Pan, Guohui, Pati, Amrita, Petras, Daniel, Reen, F Jerry, Rosconi, Federico, Rui, Zhe, Tian, Zhenhua, Tobias, Nicholas J, Yu, Yuta, Wiemann, Philipp, Wyckoff, Elizabeth, Yan, Xiaohui, Yim, Yi, Yu, Fengan, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Balskus, Emily P, Barona-Gómez, Francisco, Bechthold, Andreas, Bode, Helge B, Borriss, Rainer, Brady, Sean, Brakhage, Axel A, Caffrey, Patrick, Cheng, Yi, Clardy, Jon, Cox, Russell J, de Mot, René, Donadio, Stefano, Donia, Mohamed S, van Der Donk, Wilfred A, Dorrestein, Pieter C, Doyle, Sean, Driessen, Arnold J M, Ehling-Schulz, Monika, Entian, Karl-Dieter, Fischbach, Michael A, Gerwick, Lena, Gerwick, William H, Gross, Harald, Gust, Bertolt, Hertweck, Christian, Höfte, Monica, Jensen, Jens, Katz, Leonard, Kaysser, Leonard, Klassen, Jonathan L, Keller, Nancy P, Kormanec, Jan, Kuipers, Oscar P, Kuzuyama, Tomohisa, Kyrpides, Nikos C, Kwon, Hyung-Jin, Lautru, Sylvie, Lavigne, Rob, Lee, Chia y, Linquan, Bai, Liu, Xinyu, Liu, Wen, Luzhetskyy, Andriy, Mahmud, Taifo, Mast, Yi, Mast, Yvonne, Méndez, Carmen, Metsä-Ketelä, Mikko, Micklefield, Jason, Mitchell, Douglas A, Moore, Bradley S, Moreira, Leonilde M, Müller, Rolf, Neilan, Brett A, Nett, Markus, Nielsen, Jens, O'Gara, Fergal, Oikawa, Hideaki, Osbourn, Anne, Osburne, Marcia S, Ostash, Bohdan, Payne, Shelley M, Pernodet, Jean-Luc, Petricek, Miroslav, Piel, Jörn, Ploux, Olivier, Raaijmakers, Jos M, Salas, José A, Schmitt, Esther K, Scott, Barry, Seipke, Ryan F, Shen, Ben, Sherman, David H, Sivonen, Kaarina, Smanski, Michael J, Sosio, Margherita, Stegmann, Evi, Süssmuth, Roderich D, Tahlan, Kapil, Thomas, Christopher M, Tang, Yi, Truman, Andrew W, Viaud, Muriel, Walton, Jonathan D, Walsh, Christopher T, Weber, Tilmann, van Wezel, Gilles P, Wilkinson, Barrie, Willey, Joanne M, Wohlleben, Wolfgang, Wright, Gerard D, Ziemert, Nadine, Zhang, Changsheng, Zotchev, Sergey B, Breitling, Rainer, Takano, Eriko, Glöckner, Frank Oliver, Moore, Jon, Ju, Guohui, Ju, Xiaohui   +156 more
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Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

Frontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide ...
Koen Hoogendoorn, Koen Hoogendoorn, Lena Barra, Cees Waalwijk, Jeroen S. Dickschat, Theo A. J. van der Lee, Marnix H. Medema   +6 more
doaj   +4 more sources

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

Journal of Fungi, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites. To access this biosynthetic potential for biotechnological applications,
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +1 more source

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

Nucleic Acids Res., 2022
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...
Barbara R. Terlouw, K. Blin, J. Navarro-Muñoz, Nicole E. Avalon, M. Chevrette, Susan Egbert, Sanghoon Lee, David Meijer, Michael J J Recchia, Zachary L. Reitz, Jeffrey A. van Santen, Nelly Sélem-Mojica, T. Tørring, Liana Zaroubi, Mohammad Alanjary, Gajender Aleti, César Aguilar, Suhad A. A. Al-Salihi, Hannah E. Augustijn, J. A. Avelar-Rivas, L. A. Avitia-Dominguez, F. Barona-Gómez, Jordan Bernaldo-Agüero, Vincent A. Bielinski, Friederike Biermann, Thomas J. Booth, Victor J Carrion Bravo, R. Castelo-Branco, F. Chagas, Pablo Cruz-Morales, Chao Du, Katherine R. Duncan, A. Gavriilidou, Damien Gayrard, K. Gutiérrez-García, K. Haslinger, Eric J. N. Helfrich, J. V. D. van der Hooft, A. Jati, Edward Kalkreuter, Nikolaos Kalyvas, K. Kang, S. Kautsar, Wonyong Kim, Aditya M. Kunjapur, Yong-Xin Li, Geng-Min Lin, Catarina Loureiro, Joris J. R. Louwen, Nico L L Louwen, G. Lund, Jonathan Parra, B. Philmus, Bita Pourmohsenin, Lotte J U Pronk, Adriana Rego, D. Rex, S. Robinson, L. R. Rosas-Becerra, E. T. Roxborough, M. Schorn, D. Scobie, K. S. Singh, N. Sokolova, Xiaoyu Tang, Daniel W. Udwary, A. Vigneshwari, Kristiina Vind, Sophie P J M Vromans, Valentin Waschulin, Sam E. Williams, Jaclyn M. Winter, Thomas E. Witte, Huali Xie, Dong Yang, Jingwei Yu, Mitja M. Zdouc, Zheng Zhong, J. Collemare, Roger G. Linington, T. Weber, M. Medema   +81 more
semanticscholar   +1 more source

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

bioRxiv, 2022
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in mutualistic symbiosis with entomopathogenic nematodes produce a myriad of natural
Yi‐Ming Shi, Merle Hirschmann, Yan‐Ni Shi, Shabbir Ahmed, D. Abebew, Nicholas J. Tobias, Peter Grün, Jan J. Crames, Laura Pöschel, Wolfgang Kuttenlochner, C. Richter, J. Herrmann, Rolf Müller, A. Thanwisai, Sacha J. Pidot, T. Stinear, M. Groll, Yonggyun Kim, H. Bode   +18 more
semanticscholar   +1 more source