Results 21 to 30 of about 356,384 (331)
Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi
Nature Catalysis, 2022 Terpenoids, critical components of human medicine, are the largest family of natural products. Fungi are an important source of terpenoids, but many of the corresponding biosynthetic gene clusters (BGCs) are silent in laboratory conditions.
Yujie Yuan +12 more
semanticscholar +1 more source
MicrobiologyOpen, 2023 Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus), which together generate a variety of unique secondary metabolites.
Nadim Ahmad +6 more
doaj +1 more source
The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]
Planta Medica, 2006 Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
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Plant biosynthetic gene clusters in the context of metabolic evolution
Natural product reports (Print), 2022 Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically diverse natural products to interact with their environment. These specialised metabolites typically evolve in limited taxonomic groups presumably in response to ...
S. J. Smit, Benjamin R. Lichman
semanticscholar +1 more source
A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.
Annual Review of Biochemistry, 2021 Microbial natural products have provided an important source of therapeutic leads and motivated research and innovation in diverse scientific disciplines.
Brett C Covington +2 more
semanticscholar +1 more source
The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces
Communications Chemistry, 2022 The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential.
Doris A. van Bergeijk +8 more
doaj +1 more source
Journal of Chemical Information and Modeling, 2021 Research in natural products, the genetically encoded small molecules produced by organisms in an idiosyncratic fashion, deals with molecular structure, biosynthesis, and biological activity.
Allison S. Walker, J. Clardy
semanticscholar +1 more source
Sequence analysis of porothramycin biosynthetic gene cluster [PDF]
Folia Microbiologica, 2014 The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces albus subsp. albus (ATCC 39897) and sequentially characterized. A 39.7 kb long DNA region contains 27 putative genes, 18 of them revealing high similarity with homologous genes from biosynthetic ...
Najmanova, Lucie +8 more
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The emerging role of biosynthetic gene clusters in plant defense and plant interactions
PLoS Pathogens, 2021 The plant kingdom produces a diverse array of chemicals, collectively making an estimated 10 to 10 different metabolites [1,2]. These compounds are either known or likely to have important ecological functions, for example, in providing protection ...
G. Polturak, A. Osbourn
semanticscholar +1 more source
BiG-FAM: the biosynthetic gene cluster families database [PDF]
Nucleic Acids Research, 2020 AbstractComputational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbial genome sequences. Grouping homologous BGCs into Gene Cluster Families (GCFs) facilitates mapping their architectural and taxonomic diversity and provides ...
Satria A Kautsar +4 more
openaire +3 more sources