Results 151 to 160 of about 177,877 (294)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata. [PDF]

PLoS One, 2023
Iosue CL, Ugras JM, Bajgain Y, Dottor CA, Stauffer PL, Hopkins RA, Lang EC, Wykoff DD.   +7 more
europepmc   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

The AQ biosynthetic pathway and <i>pqs</i> genes.

, 2016
Giordano Rampioni, Falcone Marilena, Stephan Heeb, Emanuela Frangipani, Fletcher Matthew P., Dubern Jean-Frédéric, Visca Paolo, Livia Leoni, Cámara Miguel, Williams Paul   +9 more
openalex   +2 more sources

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Elucidation of the O-antigen structure of Escherichia coli O93 and characterization of its biosynthetic genes. [PDF]

Glycobiology, 2023
Furevi A, Ståhle J, Muheim C, Gkotzis S, Daley DO, Udekwu KI, Widmalm G.   +6 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

In vivo analysis of Drosophila chondroitin sulfate biosynthetic genes. [PDF]

J Biol Chem
Izumikawa T, Moriya A, Nakato E, Yamamoto K, Sano R, Akiyama T, Kinoshita-Toyoda A, Toyoda H, Nakato H.   +8 more
europepmc   +1 more source

Total Flavonoid Contents and the Expression of Flavonoid Biosynthetic Genes in Breadfruit (Artocarpus altilis) Scions Growing on Lakoocha (Artocarpus lakoocha) Rootstocks. [PDF]

Plants (Basel), 2023
Zhou Y, Underhill SJR.
europepmc   +1 more source

Antipsychotics upregulate lipid biosynthetic genes [PDF]

Nature Clinical Practice Neurology, 2006
openaire   +1 more source