Results 11 to 20 of about 717 (114)

Lymphoid Organs Remodeling in Non-Obese Diabetic Goto-Kakizaki Rats Immunized With SARS-CoV-2 Antigens. [PDF]

FASEB J
The Goto‐Kakizaki rat, a non‐obese model of type 2 diabetes mellitus (T2DM), exhibits lymphoid organ remodeling, including baseline thymic involution and splenic white pulp reorganization. Following completion of a three‐dose SARS CoV‐2 antigen immunization protocol, anti‐Spike IgG levels were significantly increased despite these structural changes ...
Pereira SA, Lazzarin MC, Dagli MLZ, Távora BCLF, Mauro EFL, Santoro ML, Vessoni SCS, Gonçalves LRC, Sotoyama MS, Oliveira RDN, Mattaraia VGM, Curi R.   +11 more
europepmc   +2 more sources

Minor Changes in Daily Rhythms Induced by a Skeleton Photoperiod Are Associated with Increased Adiposity and Glucose Intolerance

Advanced Biology, Volume 7, Issue 11, November 2023., 2023
Feeding during the day promotes metabolic impairments in rats. Here, the contribution of light to day‐feeding impairments is investigated by eliminating light with a skeleton photoperiod. Surprisingly, the skeleton photoperiod shifts metabolic rhythms and is also associated with metabolic issues, indicating that, in addition to proper feeding schedules,
Rebeca Méndez‐Hernández, Valentina S. Rumanova, Mara A. Guzmán‐Ruiz, Ewout Foppen, Rodrigo Moreno‐Morton, Gabriela Hurtado‐Alvarado, Carolina Escobar, Andries Kalsbeek, Ruud M. Buijs   +8 more
wiley   +1 more source

Evaluations of Anticancer Effects of Combinations of Cisplatin and Tirucallane‐Type Triterpenes Isolated from Amphipterygium adstringens (Schltdl).

Chemistry &Biodiversity, Volume 20, Issue 10, October 2023., 2023
Abstract The cytotoxic activity of combinations of masticadienonic (AMD) or 3αOH‐hydroxy‐masticadienonic (3αOH‐AMD) acids with cisplatin (CDDP) was evaluated against PC3 prostate and HCT116 colon cancer cell lines. Combinations A (half the IC50 value), B (IC50 value), and C (twice the IC50 value) were tested at a 1 : 1 ratio.
Lidia Díaz‐Sánchez, Alejandro Zentella‐Dehesa, Víctor Alberto Castro‐Torres, Noemi Silva‐Jiménez, Nadia Judith Jacobo‐Herrera, Mariano Martínez‐Vázquez   +5 more
wiley   +1 more source

Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity

Aging Cell, Volume 22, Issue 6, June 2023., 2023
Incubation of β‐cells with sera or plasma from obese rats and humans hampers mitochondrial oxidative phosphorylation and glucose‐stimulated insulin secretion (GSIS) relative to sera and plasma from lean rats and humans. Adiponectin, found at elevated levels in lean subjects, supports β‐cell function on its own, in the absence of sera, and also reverses
Ana Cláudia Munhoz, Julian D. C. Serna, Eloisa Aparecida Vilas‐Boas, Camille C. Caldeira da Silva, Tiago G. Santos, Francielle C. Mosele, Sergio L. Felisbino, Vilma Regina Martins, Alicia J. Kowaltowski   +8 more
wiley   +1 more source

Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients

Molecular Oncology, Volume 16, Issue 9, Page 1913-1930, May 2022., 2022
Epigenetic alterations related to aberrant gene expression are important regulators of malignant transformation and melanoma progression. Here, we integrated transcriptome and methylome data from a linear model of murine melanoma progression and identified promoter and/or gene body DNA methylation profiles that induced gene expression changes related ...
Debora D’Angelo Papaiz, Flávia Eichemberger Rius, Ana Luísa Pedroso Ayub, Clarice S. Origassa, Hemant Gujar, Diogo de Oliveira Pessoa, Eduardo Moraes Reis, Jérémie Nsengimana, Julia Newton‐Bishop, Christopher E. Mason, Daniel J. Weisenberger, Gangning Liang, Miriam Galvonas Jasiulionis   +12 more
wiley   +1 more source

Treatment with Distinct Antibiotic Classes Causes Different Pulmonary Outcomes on Allergic Airway Inflammation Associated with Modulation of Symbiotic Microbiota

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Background. Asthma is a chronic pulmonary disease that affects about 300 million people worldwide. Previous studies have associated antimicrobial use with allergies, but the real impact of antibiotics on asthma is still elusive. We investigated the potential impact of amoxicillin (Amox), trimethoprim/sulfamethoxazole (TMP/SMX), and metronidazole (Metro)
Gregório Grama Cavalcante, Anna Gabriella Guimarães, Camila Pereira Queiroz-Glauss, Marcela Helena Gonçalves Pereira, Angélica Samer Lallo Dias, Laila Sampaio Horta, Jamil Silvano de Oliveira, Silvia Dantas Cangussú, Paula Prazeres Magalhães, Remo Castro Russo, H. C. Santiago, Keshav Raj Paudel   +11 more
wiley   +1 more source

Effects of Low Protein‐High Carbohydrate Diet during Early and Late Pregnancy on Respiratory Quotient and Visceral Adiposity

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Background. Low Protein‐High Carbohydrate (LPHC) diet during pregnancy is considered a nutritional and health problem related to the development of maternal metabolic alterations, such as fatty liver and obesity in the perinatal and postnatal period. It is known that increase in visceral adiposity tissue (VAT) modulates maternal metabolic rate, with ...
Mónica Navarro-Meza, Mauricio Díaz-Muñoz, Perla Belén García-Solano, Raquel Cobián-Cervantes, Éricka A. de los Ríos-Arellano, Felipe Santoyo Telles, Mariela Camacho-Barrón, Ilaria Peluso   +7 more
wiley   +1 more source

Effects of Etanercept on TNF‐α Inhibition in Rats with Adenine‐Induced Chronic Kidney Disease

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Introduction. Chronic kidney disease (CKD) constitutes a chronic inflammatory state associated with an increase in inflammatory mediators and profibrotic molecules such as tumor necrosis factor‐α (TNF‐α). Etanercept (ETA) is a TNF inhibitor widely used in treatment of autoimmune inflammatory diseases.
Edgar Mendieta-Condado, Elda Cristina Villaseñor-Tapia, Francisco Javier Gálvez-Gastelum, Irinea Yáñez-Sánchez, Oscar Pizano-Martínez, Alejandro Canales-Aguirre, Ana Laura Márquez-Aguirre, Ligia Petrica   +7 more
wiley   +1 more source

Prolactin Increases the Frequency of Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in Lupus‐Prone MRL/lpr Mice

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Systemic lupus erythematosus is characterized by high levels of IgG class autoantibodies that contribute to the pathophysiology of the disease. The formation of these autoantibodies occurs in the germinal centers, where there is cooperation between follicular T helper cells (TFH) and autoreactive B cells.
Yolanda P. Alemán-García, Ricardo M. Vaquero-García, Rocio Flores-Fernández, Ezequiel M. Fuentes-Pananá, Patricia Gorocica-Rosete, Alberto Pizaña-Venegas, Luis Chávez-Sanchéz, Francico Blanco-Favela, María V. Legorreta-Haquet, Adriana K. Chávez-Rueda, Carlo Perricone   +10 more
wiley   +1 more source

Recombinant Lactococcus lactis Carrying IL‐4 and IL‐10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ‐Induced Model

Journal of Diabetes Research, Volume 2021, Issue 1, 2021., 2021
Type 1 diabetes (T1D) is an autoimmune disease that culminates in beta cell destruction in the pancreas and, subsequently, deficiency in insulin production. Cytokines play a crucial role in the development of diabetes, orchestrating the recruitment and action of immune cells, to not only destroy insulin‐producing cells but also preserve them. Therefore,
Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi, Akira Sugawara   +7 more
wiley   +1 more source