Results 231 to 240 of about 452,561 (294)

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Development and Optimization of an Aminooxy Coupling Reaction to Prepare Multivalent Bioconjugates with a Single Noncanonical Amino Acid. [PDF]

Bioconjug Chem
Gourdie RK, Boyt EL, Flood BM, Williard AC, Eisen WI, Skeen TL, Hassler AR, Wang AS, Dimaranan CR, Rothman SK, King EA, Maza JC, Young DD.   +12 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

A Bifunctional Antibody Conjugate for Marking the Location of DNA Binding Proteins on DNA Fibers. [PDF]

ACS Omega
Pokharel D, Shaik A, Gali H, Ling C, Bellani MA, Seidman MM.   +5 more
europepmc   +1 more source

Real‐Time Digital Micromotor Tracking‐Enabled Ultrasensitive Immunoassay

Advanced Science, EarlyView.
An AI‐facilitated real‐time digital micromotor tracking‐enabled immunoassay is developed, which leverages a self‐developed multi‐microparticle tracking system to monitor micromotor motion trajectories in a real‐time manner for digital protein analysis.
Jingjing Shi, Zuhua Yu, Hui Tian, Wenjiao Fan, Yuanyuan Sun, Wei Ren, Chenghui Liu   +6 more
wiley   +1 more source

3-Hydroxypropionic Acid Enhances Hair Growth-Related Signaling in Human Follicle Dermal Papilla Cells via Activation of the Wnt/β-Catenin Pathway. [PDF]

Int J Mol Sci
Jeon CY, Jo YH, Woo SA, Lee Y, Jung W, Shin DW.   +5 more
europepmc   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Proteomic analysis of mitochondria-ER contacts reveals key proteins involved in metabolic regulation in hepatocytes. [PDF]

Cell Commun Signal
Yang H, Wang X, Wang C, Zhang X, Kong B, Bai R, Xu X, Li Z, Xu T, Zhou M.   +9 more
europepmc   +1 more source

Identification of PsbS binding proteins in <i>Arabidopsis thaliana</i> leaf chloroplasts under high light using TurboID-based proximity labeling. [PDF]

Front Plant Sci
Jiao Y, Dou Y, Wang L, Zhu XG, Zheng H.
europepmc   +1 more source

Genetic Encoding of a Trifunctional Photo-Cross-Linker with a Cleavable Alkyl Ester Moiety. [PDF]

Chembiochem
Takayama M, Tsubota T, Yamaguchi T, Chiba K, Yoshida T, Hari Y, Tian YS, Takaya D, Mori A, Tsukamoto T, Ishimoto K, Ago Y, Okada Y, Sakamoto K, Doi T, Fukuzawa K, Obika S, Nakagawa S, Hino N.   +18 more
europepmc   +1 more source