Results 231 to 240 of about 277,237 (293)

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction. [PDF]

SLAS Discov
Aromokeye R, Ackerman-Berrier M, Araujo RDC, Lambousis M, Cardoza S, Chen LC, Kaplan ME, Zhu H, Penton C, Zerbinatti C, Thatcher GRJ, Marlowe T.   +11 more
europepmc   +1 more source

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

Advanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang   +15 more
wiley   +1 more source

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells. [PDF]

Proc Natl Acad Sci U S A
Moresco P, Kastan JP, Yang JI, Prabakar R, Kelley ZL, Minicozzi F, Adams DW, Cifani P, Tuveson DA, Fearon DT.   +9 more
europepmc   +1 more source

GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds

Advanced Science, EarlyView.
This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng, Xinkang Feng, Longlong Wang, Wentao Shao, Shiyu Guo, Duo Zhao, Jiajia Li, Long Yan, Long Miao, Bincheng Sun, Huihui Gao, Hongmei Qiu, Yu Hu, Linlin Kong, Robert M. Stupar, Ying‐hui Li, Li‐juan Qiu, Xiaobo Wang   +17 more
wiley   +1 more source

Remapping the spatial distribution of neutralizing sites and their immunodominance on the capsid of different topotypes of FMDV serotype O by site-directed competitive ELISA for detection of neutralizing antibodies. [PDF]

Microbiol Spectr
Zhao Q, Li F, Huang S, Xing X, Sun Y, Li P, Bao H, Fu Y, Sun P, Bai X, Yuan H, Ma X, Zhao Z, Zhang J, Wang J, Wang T, Li D, Zhang Q, Qian P, Cao Y, Li K, Li X, Lu Z.   +22 more
europepmc   +1 more source

A Molecular Recruitment Colocalization Platform for Visualizing Multi‐Protein Interactions and Engineering Biomolecular Condensates in Living Cells

Advanced Science, EarlyView.
MRC is a live‐cell method enabling visualization of protein–protein interactions and biomolecular condensates. It supports multi‐protein colocalization, binding analysis, and programmable condensate manipulation, providing a versatile platform for studying dynamic cellular organization.
Lei Peng, Yu Hou, Yan Zhao, Jing‐Ya Tang, Liu Song, Bo Peng, Min Li, Dian‐Bing Wang, Xian‐En Zhang   +8 more
wiley   +1 more source

Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein. [PDF]

J Virol
Zhang Y, Moss B.
europepmc   +1 more source

Bacterial Minicell‐Based Biohybrid Sub‐micron Swimmers for Targeted Cargo Delivery

Advanced Science, EarlyView.
Bacterial minicells, vesicles derived from engineered E. coli, offer promising sub‐micron scale biohybrid swimmers for targeted cargo delivery. Purified with over 99% efficiency while retaining motility, they are functionalized with MNPs for controlled movement.
Saadet Fatma Baltaci, Mukrime Birgul Akolpoglu, Irina Kalita, Victor Sourjik, Metin Sitti   +4 more
wiley   +1 more source