Results 31 to 40 of about 452,561 (294)

Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates

Molecules, 2023
Despite the strong anticancer activity of SN38 (7-ethyl-10-hydroxy-camptothecin), the severe side effects and loss of anticancer activity caused by the lack of selectivity to cancer cells and hydrolysis of ring E prevent its clinical application.
Yi Dai, Yang Zhang, Tianxiang Ye, Yue Chen   +3 more
doaj   +1 more source

Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines [PDF]

, 1996
A powerful and potentially general approach to the targeting and crystallization of proteins on lipid interfaces through coordination of surface histidine residues to lipid-chelated divalent metal ions is presented.
Arnold, Frances H., Chen, Chao-Tsen, Chilkoti, Ashutosh, Frey, Wolfgang, Pack, Daniel W., Schief, William R., Jr., Stayton, Patrick, Vogel, Viola   +7 more
core   +1 more source

Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer

Pharmaceutics, 2020
A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo.
Francisco Fernández-Campos, Francesc Navarro, Adrian Corrales, Jordi Picas, Eloy Pena, Jordi González, Francisco J. Otero-Espinar   +6 more
doaj   +1 more source

Structural divergence of paralogous S components from ECF-type ABC transporters [PDF]

, 2012
Energy coupling factor (ECF) proteins are ATP-binding cassette transporters involved in the import of micronutrients in prokaryotes. They consist of two nucleotide-binding subunits and the integral membrane subunit EcfT, which together form the ECF ...
Beek, Josy ter,, Berntsson, Ronnie P.-A.,, Duurkens, Ria H.,, Majsnerowska, Maria,, Poolman, Bert,, Puri, Pranav,, Slotboom, Dirk-Jan,   +6 more
core   +4 more sources

Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates?

Journal of Enzyme Inhibition and Medicinal Chemistry
Sodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi, Xiaoxiao Yang, Dongning Liu, Wen Lu, Binghe Wang   +4 more
doaj   +1 more source

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Butt, Louise, Callaghan, Anastasia, Gowers, Darren, Henderson, Charlotte, Mardle, C., Phillips, Jack, Pickford, Andy, Roberts, Adam J., Stone, Carlanne, Vincent, H.   +9 more
core   +3 more sources

Silver Azide Nanoparticles Embedded into Silica as Energetic Nano-materials

Medžiagotyra, 2015
Silver azide is a primary high explosive that can be initiated by different means. In this work, silver azide nanoparticles were obtained, embedded into silica, and further derivatized with biotin.
Petre Ionita, Corneliu Ghica, Raluca Damian, Daniela Culita, Ioana Turcu   +4 more
doaj   +1 more source

Specific Adhesion of Membranes Simultaneously Supports Dual Heterogeneities in Lipids and Proteins [PDF]

, 2015
Membrane adhesion is a vital component of many biological processes. Heterogeneities in lipid and protein composition are often associated with the adhesion site. These heterogeneities are thought to play functional roles in facilitating signalling. Here
Gordon, Vernita D., Mica, N., Ritzer, M., Shindell, O.   +3 more
core   +1 more source

Antioxidant responses of black glutinous rice to drought and salinity stresses at different growth stages

Open Agriculture
Black glutinous rice is a local pigmented rice that attracts the interest of many people due to its high nutritional value. While cultivating, black glutinous rice may experience abiotic stresses, such as drought and salinity threat. Drought and salinity
Rudiyanto Yosefine Fetik, Alfiana Okta Hadina, Putri Anandita Linggar, Rizkiantoro Ridho, Siswoyo Tri Agus   +4 more
doaj   +1 more source

Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier

Molecules, 2013
Dendrimers are highly customizable nanopolymers with qualities that make them ideal for drug delivery. The high binding affinity of biotin/avidin provides a useful approach to fluorescently label synthesized dendrimer-conjugates in cells and tissues.
Heather A. Bullen, Kristi L. Haik, Celeste Morris, Steven Wall, Anthony Haskamp, Megan Caroway, Michael Hester, Robert Spaulding, Brett Rossow, Ruth Hemmer, Andrew Hall   +10 more
doaj   +1 more source