Results 61 to 70 of about 8,870 (277)

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene)bis(pyrimidin-2-amine) derivatives

Chemistry Central Journal, 2018
Background Pyrimidine molecules attracted organic chemists very much due to their biological and chemotherapeutic importance. Their related fused heterocycles are of interest as potential bioactive molecules so, we have designed and prepared a new class ...
Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani, Syed Adnan Ali Shah, Balasubramanian Narasimhan   +5 more
doaj   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

2-[2,5-Dimethoxy-4-(3-nitropyridin-2-yl)phenyl]-3-nitropyridine

IUCrData
The title compound, C18H14N4O6, was prepared in a larger project on condensed heterocycles with a focus on the Cadogan reaction. Extension of this method to multiple Cadogan reactions was explored as a way to larger conjugated systems.
Mario Geffe, Heiner Detert, Dieter Schollmeyer   +2 more
doaj   +1 more source

Synthesis, Molecular Structure and Spectroscopic Investigations of Novel Fluorinated Spiro Heterocycles

Molecules, 2015
This paper describes an efficient and regioselective method for the synthesis of novel fluorinated spiro-heterocycles in excellent yield by cascade [5+1] double Michael addition reactions.
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Assem Barakat, Saied M. Soliman, Hazem A. Ghabbour, Ching Kheng Quah, Hoong-Kun Fun   +6 more
doaj   +1 more source

Synthesis of Bis-Heterocyclic 1H-Imidazole 3-Oxides from 3-Oxido-1H-imidazole-4-carbohydrazides [PDF]

, 2012
The reaction of 1H-imidazole-4-carbohydrazides 1, which are conveniently accessible by treatment of the corresponding esters with NH2NH2·H2O, with isothiocyanates in refluxing EtOH led to thiosemicarbazides (= hydrazinecarbothioamides) 4 in high yields ...
Heimgartner, H, Mlostoń, G, Pieczonka, A M   +2 more
core   +1 more source

Integrated Visible Light and Oxidant Protection Through Multifunctional Sunscreens

Advanced Healthcare Materials, EarlyView.
High‐energy visible radiation (HEVR), although less energetic than UV light, penetrates deeper into the skin and contributes to photoaging, pigmentation disorders, and oxidative stress. The development of new HEVR‐targeted filters, therefore, represents not only a scientific challenge but also a pressing public health and cosmetic industry need.
Beatriz Peñín, Raúl Losantos, Ignacio Funes‐Ardoiz, Diego Sampedro   +3 more
wiley   +1 more source

Configuration-Dependent Medium-Sized Ring Formation: Chiral Molecular Framework with Three-Dimensional Architecture [PDF]

, 2020
This report describes a configuration-dependent [6 + 8 + 5] fused ring formation via a tandem cyclic N-acyliminium nucleophilic addition reaction. Cyclization of the acyclic precursor prepared on a solid phase using l-Ser and a racemic mixture of Fmoc ...
Cankarova, Nadezda, Krajcovicova, Sona, Krchnak, Viktor, la Venia, Agustina   +3 more
core   +1 more source

Backbone Engineering of Carbon‐Centered NHC‐Derived Diradicals: From Electronic State Tuning to High‐Performance Organic Field‐Effect Transistors

Advanced Materials, EarlyView.
The open‐shell nature of diradicals facilitates charge separation, and compounds with moderate diradical character demonstrate remarkable potential in organic field‐effect transistors (OFET) applications due to their low reorganization energies for hole and electron transport.
Xiao‐Xu Liu, Lianghui Li, Xin Li, Can Chen, Man Li, Shun Tian, Paul J. Dyson, Ying‐Feng Han   +7 more
wiley   +1 more source

Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018
This research involves preparation of many bisheterocycles attached to pyrrole rings have been synthesized by the stepwise procedure such asbis(1,2-dihydropyridazine-3,6-dione) (3),bis(2,3dihydrophthalazine-1,4-dione) (4) and bis(tetrahydropyridazine-3 ...
Ayad Kareem Khan
doaj   +1 more source

Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2022
A new imidazole-2-thione fused furazan biheterocyclic group was synthesized and its biological activity was investigated. Nitrogen rich heterocycles, imidazole-2-thione and 1,2,5-oxadiazole (furazan) have been conveni ently fused.
Gülşah Kurt, Fatih Sevgi
doaj   +1 more source