Results 11 to 20 of about 2,355 (158)

The Demethoxy Derivatives of Curcumin Exhibit Greater Differentiation Suppression in 3T3-L1 Adipocytes Than Curcumin: A Mechanistic Study of Adipogenesis and Molecular Docking

Biomolecules, 2021
Curcumin is a known anti-adipogenic agent for alleviating obesity and related disorders. Comprehensive comparisons of the anti-adipogenic activity of curcumin with other curcuminoids is minimal.
Ahmed Alalaiwe, Jia-You Fang, Hsien-Ju Lee, Chun-Hui Chiu, Ching-Yun Hsu   +4 more
doaj   +1 more source

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials. [PDF]

Food Sci Nutr
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Momal U, Shahbaz M, Perween A, Hassan MHU, Naeem H, Shahid Z, Hussain M, Imran M, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, Ghoneim MM, FentaYehuala T, Selim S, Mostafa EM.   +14 more
europepmc   +2 more sources

Dietary bisdemethoxycurcumin supplementation attenuates lipopolysaccharide-induced damages on intestinal redox potential and redox status of broilers

Poultry Science, 2021
This study was conducted to investigate the beneficial effects of bisdemethoxycurcumin (BDC) on growth performance, glutathione (GSH) redox potential, antioxidant enzyme defense, and gene expression in lipopolysaccharide (LPS)-challenged broilers.
Jingfei Zhang, Hongli Han, Lili Zhang, Tian Wang   +3 more
doaj   +1 more source

Interaction of Thiol Antioxidants with α,β-Unsaturated Ketone Moiety: Its Implication for Stability and Bioactivity of Curcuminoids

Molecules, 2023
Many biological functions of curcumin have been reported. As certain bioactivities of curcumin are eliminated by antioxidants, reactive oxygen species generated by curcumin have been suggested as a relevant mechanism. In the present study, the effects of
Bo Hyun Lee, Eiseul Song, Jungil Hong
doaj   +1 more source

Curcuminoids: production, properties and application. Report 2. Antioxidant and antimutagenic activity of curcuminoids

Современная наука и инновации, 2023
As a result of studies, it has been shown that the antioxidant activity in the series curcumin, bisdemethoxycurcumin, demethoxycurcumin decreases. The TEAС value was determined for curcumin, bisdemethoxycurcumin, demethoxycurcumin, which is 0.41, 0.32 ...
M. A. Kapustin, A. S. Chubarova, I. A. Evdokimov, A. D. Lodygin, S. V. Lodygina, N. V. Dudchik, V. G. Cigankov, A. M. Bondaruk, V. P. Kurchenko   +8 more
doaj   +1 more source

Studies on Curcumin and Curcuminoids. XXXIX. Photophysical Properties of Bisdemethoxycurcumin [PDF]

Journal of Fluorescence, 2010
The steady-state absorption and fluorescence, as well as the time-resolved fluorescence properties of bisdemethoxycurcumin dissolved in several solvents differing in polarity and H-bonding capability were measured. The photodegradation quantum yield of the compound in acetonitrile and methanol was determined.
NARDO, LUCA, Andreoni, A, Masson, M, Haukvik, T, Tonnesen, H.   +4 more
openaire   +3 more sources

BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin [PDF]

Physiological Reports, 2016
The B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) locus encodes a 37-kD protein that is a key regulatory component of the polycomb regulatory complex 1 (PRC1). When overexpressed in various cancer types, the BMI1 protein induces cell growth and promotes tumor growth in vitro and in vivo.
Adeyeni, Temitope A., Khatwani, Natasha, San, KayKay, Ezekiel, Uthayashanker R.   +3 more
openaire   +2 more sources

Stereoselective Reduction of Bisdemethoxycurcumin to ()-Hexahydrobisdemethoxycurcumin by Cultured Plant Cells

Natural Product Communications, 2020
Biotransformation of bisdemethoxycurcumin was examined using cultured plant cells of Morus bombycis , the Moraceae mulberry family, as biocatalysts. The cultured cells converted bisdemethoxycurcumin into ( R )-hexahydrobisdemethoxycurcumin in 30% yield ...
Kei Shimoda, Naoji Kubota, Hiroki Hamada, Kouki Kawakami, Noriyuki Nakayama, Hatsuyuki Hamada   +5 more
doaj   +1 more source

Leveraging host metabolism for bisdemethoxycurcumin production in Pseudomonas putida [PDF]

Metabolic Engineering Communications, 2019
ABSTRACT Pseudomonas putida is a saprophytic bacterium with robust metabolisms and strong solvent tolerance making it an attractive host for metabolic engineering and bioremediation. Due to its diverse carbon metabolisms, its genome encodes an array of proteins and enzymes that can be readily applied
Incha, Matthew R, Thompson, Mitchell G, Blake-Hedges, Jacquelyn M, Liu, Yuzhong, Pearson, Allison N, Schmidt, Matthias, Gin, Jennifer W, Petzold, Christopher J, Deutschbauer, Adam M, Keasling, Jay D   +9 more
openaire   +5 more sources

Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich extract: Relevance to the treatment of Alzheimer’s disease

SAGE Open Medicine, 2020
Objectives: Cholinesterase inhibition is a common strategy to treat Alzheimer’s disease. In this study, we have investigated the cholinesterase inhibitory effects of a first-of-its-kind turmeric extract (REVERC3) having enriched content of ...
Sudeep HV, Amritha Raj, Gouthamchandra K, Chandrappa S, Shyamprasad K   +4 more
doaj   +1 more source