Results 1 to 10 of about 2,546 (159)

Demethoxycurcumin exhibits amoebicidal activity against Acanthamoeba triangularis trophozoites and cysts and inhibits encystation [PDF]

Current Research in Parasitology and Vector-Borne Diseases
Acanthamoeba is a ubiquitous free-living protist commonly found in soil and water, with the T4 genotype responsible for most human infections. Treatment remains challenging due to the limited efficacy of current therapeutics and the parasite’s ability to
Rachasak Boonhok, Wilaiwan Senghoi, Aman Tedasen, Suthinee Sangkanu, Chooi Ling Lim, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Karma G. Dolma, Alok K. Paul, Madhu Gupta, Md Atiar Rahman, Kingkan Bunluepuech, Shanmuga Sundara, Tooba Mahboob, Veeranoot Nissapatorn   +16 more
doaj   +2 more sources

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials. [PDF]

Food Sci Nutr
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Momal U, Shahbaz M, Perween A, Hassan MHU, Naeem H, Shahid Z, Hussain M, Imran M, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, Ghoneim MM, FentaYehuala T, Selim S, Mostafa EM.   +14 more
europepmc   +2 more sources

Therapeutic potential of Curcuma longa against monkeypox: antioxidant, anti-inflammatory, and computational insights [PDF]

Frontiers in Chemistry
BackgroundMonkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agents.
Farouk Boudou, Amal Belakredar, Ahcen Keziz, Linda Aissani, Huda Alsaeedi, David Cronu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum   +8 more
doaj   +2 more sources

Antibiotic discovery with artificial intelligence for the treatment of Acinetobacter baumannii infections [PDF]

mSystems
Global challenges presented by multidrug-resistant Acinetobacter baumannii infections have stimulated the development of new treatment strategies. We reported that outer membrane protein W (OmpW) is a potential therapeutic target in A. baumannii. Here, a
Yassir Boulaamane, Irene Molina Panadero, Abdelkrim Hmadcha, Celia Atalaya Rey, Soukayna Baammi, Achraf El Allali, Amal Maurady, Younes Smani   +7 more
doaj   +2 more sources

Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

Acta Pharmaceutica, 2021
The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C.
Monton Chaowalit, Chuanchom Panupong, Popanit Puwadon, Settharaksa Sukanya, Pathompak Pathamaporn   +4 more
doaj   +1 more source

The Demethoxy Derivatives of Curcumin Exhibit Greater Differentiation Suppression in 3T3-L1 Adipocytes Than Curcumin: A Mechanistic Study of Adipogenesis and Molecular Docking

Biomolecules, 2021
Curcumin is a known anti-adipogenic agent for alleviating obesity and related disorders. Comprehensive comparisons of the anti-adipogenic activity of curcumin with other curcuminoids is minimal.
Ahmed Alalaiwe, Jia-You Fang, Hsien-Ju Lee, Chun-Hui Chiu, Ching-Yun Hsu   +4 more
doaj   +1 more source

Interaction of Thiol Antioxidants with α,β-Unsaturated Ketone Moiety: Its Implication for Stability and Bioactivity of Curcuminoids

Molecules, 2023
Many biological functions of curcumin have been reported. As certain bioactivities of curcumin are eliminated by antioxidants, reactive oxygen species generated by curcumin have been suggested as a relevant mechanism. In the present study, the effects of
Bo Hyun Lee, Eiseul Song, Jungil Hong
doaj   +1 more source

The impact of curcumin derived polyphenols on the structure and flexibility COVID-19 main protease binding pocket: a molecular dynamics simulation study [PDF]

PeerJ, 2021
The newly occurred SARS-CoV-2 caused a leading pandemic of coronavirus disease (COVID-19). Up to now it has infected more than one hundred sixty million and killed more than three million people according to 14 May 2021 World Health Organization report ...
Aweke Mulu, Mulugeta Gajaa, Haregewoin Bezu Woldekidan, Jerusalem Fekadu W/mariam   +3 more
doaj   +2 more sources

Curcuminoids: production, properties and application. Report 2. Antioxidant and antimutagenic activity of curcuminoids

Современная наука и инновации, 2023
As a result of studies, it has been shown that the antioxidant activity in the series curcumin, bisdemethoxycurcumin, demethoxycurcumin decreases. The TEAС value was determined for curcumin, bisdemethoxycurcumin, demethoxycurcumin, which is 0.41, 0.32 ...
M. A. Kapustin, A. S. Chubarova, I. A. Evdokimov, A. D. Lodygin, S. V. Lodygina, N. V. Dudchik, V. G. Cigankov, A. M. Bondaruk, V. P. Kurchenko   +8 more
doaj   +1 more source

Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria)

Jurnal Biota, 2023
Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and ...
Putu Oky Ari Tania, Candra Rini Hasanah Putri, Ayling Sanjaya, Titiek Sunaryati, Deddy Hartanto, Erlix R Purnama, Meivy Isnoviana   +6 more
doaj   +1 more source