Results 41 to 50 of about 2,546 (159)

Effects of curcumin and its derivatives on a glioma cell line

Current Issues in Pharmacy and Medical Sciences
Glioblastomas are highly invasive brain tumors associated with oxidative stress (OS) and chronic inflammation. Curcumin (CUR), the principal bioactive compound of Curcuma longa, as well as its natural analogues demethoxycurcumin (DMC) and ...
Weronika Wiącek, Dorota Luchowska-Kocot, Anna Horecka   +2 more
doaj   +1 more source

Recent Advances in the Use of Natural Deep Eutectic Solvents for Natural Product Sample Preparation: Focus on Purification, Characterization, and Sustainability

Journal of Separation Science, Volume 49, Issue 7, July 2026.
ABSTRACT This review examines recent advances in the use of natural deep eutectic solvents (NaDES) for natural product sample preparation, with emphasis on extraction, purification, analytical compatibility, and sustainability. NaDES emerge as versatile, tunable, and biocompatible media that enhance the recovery and stability of diverse phytochemicals ...
Valeria Cedeño‐Fierro, Juan Felipe Grisales‐Mejía, Harlen Gerardo Torres Castañeda, Jose A. Mendiola   +3 more
wiley   +1 more source

ABCG2 downregulation in glioma stem cells enhances the therapeutic efficacy of demethoxycurcumin

Oncotarget, 2017
We analyzed the role of ABCG2, a drug transporter, in determining the sensitivity of glioma stem cells (GSCs) to demethoxycurcumin (DMC). We first demonstrated that ABCG2 is more highly expressed in GSCs than primary astrocytes. Modulation of ABCG2 levels in GSCs by transfection of ABCG2 shRNA or a lentiviral vector encoding ABCG2 revealed an inverse ...
Chen, Long, Shi, Lei, Wang, Wenhua, Zhou, Youxin   +3 more
openaire   +3 more sources

Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells [PDF]

In Vivo, 2020
Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo.
Fu-Shin, Chueh, Jin-Cherng, Lien, Yu-Cheng, Chou, Wen-Wen, Huang, Yi-Ping, Huang, Jye-Yu, Huang, Jung-Yu, Kuo, Wan-Ni, Huang, Shou-Yi, Sheng, Hao-Yun, Tung, Hung-Yi, Chen, Shu-Fen, Peng   +11 more
openaire   +2 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Evaluating the Effects of Nanocurcumin Supplementation in Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This meta‐analysis of trials was conducted to assess the effect of nanocurcumin supplementation in type 2 diabetes mellitus. ABSTRACT Background Nanocurcumin has been developed to overcome the poor bioavailability of conventional curcumin and has been proposed as a potential adjunctive therapy for type 2 diabetes mellitus (T2DM).
Sahar Ghoflchi, Mohammad Jalili‐Nik, Seyed Isaac Hashemy, Sercan Karav, Hossein Hosseini, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Demethoxycurcumin Preserves Renovascular Function by Downregulating COX‐2 Expression in Hypertension

Oxidative Medicine and Cellular Longevity, 2016
Hypertension‐associated endothelial dysfunction is largely due to the exaggerated vasoconstrictor generation by cyclooxygenase‐2 (COX‐2). COX‐2 is induced under inflammatory condition. Demethoxycurcumin (DMC) is a major component of Curcuma longa L, which possesses anti‐inflammatory action.
Yingjuan Li, Danyang Tian, Chunhua Zhu, Liqun Ren   +3 more
openaire   +2 more sources

Characterization, Antioxidant and Cytotoxic Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin from Curcuma longa Cultivated in Costa Rica

Separations
The biological activities of curcuminoids, the main polyphenol constituents of Curcuma longa (turmeric), have been the subject of many studies in recent years.
Andrea Mariela Araya-Sibaja, Felipe Vargas-Huertas, Silvia Quesada, Gabriela Azofeifa, José Roberto Vega-Baudrit, Mirtha Navarro-Hoyos   +5 more
doaj   +1 more source

Phương pháp phân tích nhanh hàm lượng curcumin, demethoxycurcumin và bisdemethoxycurcumin từ củ nghệ bằng hệ thống HPLC 1260 agilent

Tạp chí Khoa học và Công nghệ, 2023
Trong nghiên cứu này, phương pháp phân tích curcumin (1), demethoxycurcumin (2) và bisdemethoxycurcumin (3) đơn giản, dễ thực hiện với độ đặc hiệu, độ tin cậy cao bằng hệ thống sắc ký lỏng hiệu năng cao (HPLC) đã được xây dựng.
Nguyễn Phi Hùng, Nguyễn Anh Tuấn, Đinh Thị Tú, Tô Đạo Cường, Hoàng Thị Phương, Đặng Ngọc Quang, Đỗ Thị Thúy, Vũ Thị Hà, Bùi Thị Thực, Trịnh Thị Thu Hà   +9 more
doaj  

Curcumin Nanoformulations for Dermatological Applications: From Nutraceuticals to Nanocarriers

Food Frontiers, Volume 7, Issue 3, May 2026.
Nanotechnology‐based delivery platforms enhance the cutaneous administration of curcumin. Loading free curcumin into polymeric micelles, metal‐based nanoparticles, nanogels/hydrogels, liposomes, polymeric nanoparticles, or nanoemulsions/nanocrystals helps address its low solubility, poor stability and limited skin permeation. As a result, these systems
Stephany Celeste Gutiérrez‐Ruiz, Alejandra Romero‐Montero, Hector Hernández‐Parra, Sheila I. Peña‐Corona, Héctor Adrián García‐Gasca, Katya Carbone, Fabio Gervasi, Shivaprasad Shetty Mangalpady, Rajesh Kaverikana, Mariia Shanaida, Volodymyr Shanaida, Daniela Calina, Javad Sharifi‐Rad, Gerardo Leyva‐Gómez   +13 more
wiley   +1 more source