Results 31 to 40 of about 2,355 (158)

A validated HPLC-MS/MS method for simultaneously analyzing curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetra-hydrocurcumin and piperine in human plasma, urine or feces

Heliyon, 2023
Background: The spice curcumin is supposed to have many different beneficial health effects. To understand the complete pharmacokinetics of curcumin we need an analytical method to determine curcumin and its metabolites in human plasma, urine or feces ...
M.A.G.M. Kroon, H.W.M. van Laarhoven, E.L. Swart, E.M. Kemper, O. van Tellingen   +4 more
doaj   +1 more source

Characterization, Antioxidant and Cytotoxic Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin from Curcuma longa Cultivated in Costa Rica

Separations
The biological activities of curcuminoids, the main polyphenol constituents of Curcuma longa (turmeric), have been the subject of many studies in recent years.
Andrea Mariela Araya-Sibaja, Felipe Vargas-Huertas, Silvia Quesada, Gabriela Azofeifa, José Roberto Vega-Baudrit, Mirtha Navarro-Hoyos   +5 more
doaj   +1 more source

Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction

Oncology Letters, 2014
Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated in vivo using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving the physical and mental capacity of the mice.
LUO, CHANGJIANG, DU, ZHIXING, WEI, XING, CHEN, GANG, FU, ZHONGXUE   +4 more
openaire   +3 more sources

Influence of different drying techniques on the quality and physicochemical properties of Ghana‐sourced turmeric (Curcuma longa L.) samples

JSFA reports, EarlyView.
Abstract Background This study evaluated the influence of four drying techniques—freeze drying (FZD), microwave drying (MCD), oven drying (OVD), and sun drying (SUD)—on the bioactive, nutritional, and physical properties of turmeric. Using standard analytical procedures, the samples were examined for antioxidant activity (DPPH and ABTS assays), total ...
Eric Antiri Aforo, Richard Osae, Maurice Tibiru Apaliya, Irene Akua Idun, Emmanuel Kwaw, Raphael N. Alolga, Francis Appiah   +6 more
wiley   +1 more source

The Mechanism of Bisdemethoxycurcumin Enhances Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus [PDF]

International Journal of Molecular Sciences, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) infection has posed a serious threat to public health, therefore, the development of new antibacterial drugs is imperative. Bisdemethoxycurcumin (BDMC) is a curcumin analog that exists in nature and possesses extensive pharmacological actions.
Shu Wang, Min-Chul Kim, Ok-Hwa Kang, Dong-Yeul Kwon   +3 more
openaire   +2 more sources

Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols

Photochemistry and Photobiology, EarlyView.
This review addresses the critical challenges in translating in vitro antimicrobial photodynamic therapy protocols to in vivo models, with a particular focus on the hurdles of standardization. The vast diversity in photosensitizers and light parameters across different target cells and models requires a rigorous optimization process.
Lívia Mara Alves Figueiredo‐Godoi, Ana Júlia Barbosa Tomé, Cristina Kurachi   +2 more
wiley   +1 more source

Antioxidant, Antidiabetic and Cytoprotective Activities of Synthetic Chloro‐Curcumin Derivatives in C2C12 Myotubes

Applied Research, Volume 5, Issue 4, August 2026.
Structural reengineering of curcumin generated derivatives with antioxidant, cytoprotective and glucose‐modulating activities. These compounds improved cellular responses to hyperglycaemic stress in C2C12 myotubes, highlighting their potential as candidates for managing oxidative stress–related metabolic disorders, particularly type 2 diabetes mellitus.
Adesola Oluwaseun Adeleye, Oluwafemi Omoniyi Oguntibeju, Salam Titinchi, Chinyerum Sylvia Opuwari   +3 more
wiley   +1 more source

Selective Anti‐Inflammatory Actions of Curcumin on Cytokine Pathways in Major Depressive Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
Curcumin partially attenuates IRS/M1/Th1 immune activation in MDD patients ex vivo, but fails to normalize it. Paradoxically, it upregulates immune profiles in healthy controls. Its immunomodulatory effects are state‐dependent, suggesting cautious use in non‐depressed individuals.
Tangcong Chen, Yueyang Luo, Mengqi Niu, Jing Li, Mengdie Li, Yingqian Zhang, Michael Maes   +6 more
wiley   +1 more source

Comparative Study of the Effects of Curcuminoids and Tetrahydrocurcuminoids on Melanogenesis: Role of the Methoxy Groups

Future Pharmacology
Curcuminoids are naturally occurring yellow-colored compounds that, when hydrogenated to remove their conjugated double bond, become colorless and are referred to as tetrahydrocurcuminoids.
Shilpi Goenka
doaj   +1 more source

Optimizing the Anti‐Inflammatory Efficacy of Pakistani Spice Blends: A Farm‐to‐Fork Analysis of Phytochemical Synergy and Processing Stability

eFood, Volume 7, Issue 4, August 2026.
This review aims to evaluate the anti‐inflammatory potential of these spice blends, emphasizing their synergistic mechanisms, and to investigate how cultivation practices, post‐harvest processing, and environmental stressors shape their medicinal efficacy. By addressing this gap, it seeks to provide a comprehensive framework for integrating traditional
Qudrat Ullah, Waqas Haider, Farhang Hameed Awlqadr, Ahmed Bilal, Muhammad Tayyab Arshad, Emmanuel Laryea   +5 more
wiley   +1 more source