Results 51 to 60 of about 2,355 (158)

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Drug Design, Development and Therapy, 2020
Chengjiang Qiu,1 Kairui Liu,1 Sheng Zhang,1 Simin Gao,2 Weirun Chen,1 Dateng Li,3 Youxing Huang1 1Department of Abdominal Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, People’s ...
Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y   +6 more
doaj  

Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and –independent apoptosis via Smad or Akt signaling pathways in HOS cells

BMC Complementary Medicine and Therapies, 2020
Background Osteosarcoma is the most common primary malignant bone tumor in children and adolescents and has also been associated with a high degree of malignancy and enhanced metastatic capacity.
Cheng Huang, Hsu-Feng Lu, Yu-Hsuan Chen, Jui-Chieh Chen, Wen-Hsiang Chou, Hsiu-Chen Huang   +5 more
doaj   +1 more source

Curcumin/Turmeric Supplementation on Glycemic Control in Adults With Prediabetes and Type 2 Diabetes: A Systematic Review and Dose–Response Meta‐Analysis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This meta‐analysis of 34 randomized controlled trials shows that curcumin/turmeric supplementation significantly improves glycemic control in prediabetes and type 2 diabetes. Key reductions were observed in fasting blood glucose (−10.15 mg/dL), HbA1c (−0.32%), fasting insulin, and HOMA‐IR.
Hossein Bahari, Mostafa Shahraki Jazinaki, Zahra Asadi, Haniyeh Golafrouz   +3 more
wiley   +1 more source

Bisdemethoxycurcumin promotes apoptosis in human platelets via activation of ERK signaling pathway

Toxicology in Vitro, 2020
Curcumin, a major bioactive component of turmeric (Curcuma longa), is known for its multiple health benefits. Curcumin as such is a mixture of its analogs: bisdemethoxycurcumin (BDMC)-3%, and demethoxycurcumin (DMC)-17%. Although the effect of curcumin on platelets is documented, the effect of BDMC and DMC on platelets is less studied.
Paul, Manoj, Manikanta, K., Hemshekhar, M., Sundaram, Mahalingam S., Naveen, S., Ramesh, T. N., Kemparaju, K., Girish, K. S.   +7 more
openaire   +3 more sources

Targeting the Dynamic Susceptibility Window: Time‐Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp

Lasers in Surgery and Medicine, Volume 58, Issue 4, Page 331-342, April 2026.
ABSTRACT Objective Evaluated the antimicrobial efficacy of curcumin‐mediated photodynamic inactivation (PDI) against both sensitive and resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes, as well as its potential to enhance antibiotic effects (amoxicillin, ceftriaxone, erythromycin).
Isabella S. Gonçalves, Jennifer M. Soares, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

Metabolites Identification of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin in Rats After Oral Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with Mass Spectrometry

World Journal of Traditional Chinese Medicine, 2016
Background: Curcuminoids are promising cancer chemopreventive agents. Curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the major bioactive curcuminoids in turmeric. However, comprehensive metabolic studies of these three curcuminoids
Rui Li, Qi Wang, Jing-Ran Fan, Jun-Bin He, Xue Qiao, Cheng Xiang, De-An Guo, Min Ye   +7 more
doaj   +1 more source

Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole [PDF]

European Journal of Chemistry, 2017
The antioxidant activity of new hydrazones derived from bisdemethoxycurcumin pyrazole was investigated. The study was divided into two main parts: The first one includes the synthesis and characterization of the target compounds from bisdemethoxycurcumin (BDMC), while the second step is devoted to the investigation of their antioxidant activities.
Tahseen Abdul Qader Alsalim, Hussain Ali Mzban, Einas Nasir Abood   +2 more
openaire   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Effects of curcumin and its derivatives on a glioma cell line

Current Issues in Pharmacy and Medical Sciences
Glioblastomas are highly invasive brain tumors associated with oxidative stress (OS) and chronic inflammation. Curcumin (CUR), the principal bioactive compound of Curcuma longa, as well as its natural analogues demethoxycurcumin (DMC) and ...
Weronika Wiącek, Dorota Luchowska-Kocot, Anna Horecka   +2 more
doaj   +1 more source

In Silico analysis, prediction and ranking of Drug binding affinity of Cyclooxygenase-2(COX2) and Nuclear Factor KappaB (NFkB) using Curcumin and its analogues in Cancer Treatment [PDF]

BIO Web of Conferences
This present study investigates the binding affinities of curcumin and its derivatives with Nuclear Factor Kappa B(NF-kB) and Cyclooxygenase-2(COX-2), the most targeted molecules in oncological therapies.
B Athira, S Lakshmi Priyadarsini
doaj   +1 more source