Results 61 to 70 of about 2,355 (158)

Bisdemethoxycurcumin inhibits PDGF‐induced vascular smooth muscle cell motility and proliferation [PDF]

Molecular Nutrition & Food Research, 2013
ScopeA key event in the development of plaque in the arteries is the migration and proliferation of smooth muscle cells (SMCs) from the media to the intima of the blood vessel. This study was conducted to evaluate the effects of bisdemethoxycurcumin (BC), a naturally occurring structural analog of curcumin (CC), on platelet‐derived growth factor (PDGF)‐
Yinan, Hua, Julia, Dolence, Shalini, Ramanan, Jun, Ren, Sreejayan, Nair   +4 more
openaire   +2 more sources

Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection

iMeta, Volume 5, Issue 1, February 2026.
DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN‐I) pathway through the CRYAB‐RBM26 axis. This molecular axis serves as a key downstream regulator for DMC/CUR activation of the IFN‐I pathway.
Tingting Chen, Xiang Wang, Guangyuan Zhang, Lu Wang, Junhao Wan, Lirong Tan, Xinyue Fan, Siqin Meng, Zhixing Jin, Yuzhang Liang, Haoze Li, Ziyuan Wan, Xiaotong Xu, Yan Zhang, Li Qin, Anna Malashicheva, Yu Du, Guangchao Zang, Guixue Wang   +18 more
wiley   +1 more source

Biomedical Promise of Sustainable Microwave-Engineered Symmetric Curcumin Derivatives

Pharmaceutics
Curcumin is a polyphenol of the Curcuma longa plant, which can be used for various medicinal purposes, such as inflammation and cancer treatment. In this context, two symmetric curcumin derivatives (D1—(1E,6E)-1,7-bis(4-acetamidophenyl)hepta-1,6-diene-3 ...
Cristina Doina Niţu, Maria Mernea, Raluca Ioana Vlasceanu, Bianca Voicu-Balasea, Madalina Andreea Badea, Florentina Monica Raduly, Valentin Rădiţoiu, Alina Rădiţoiu, Speranta Avram, Dan F. Mihailescu, Ionela C. Voinea, Miruna Silvia Stan   +11 more
doaj   +1 more source

HPLC Method for Simultaneous Quantitative Detection of Quercetin and Curcuminoids in Traditional Chinese Medicines

Journal of Pharmacopuncture, 2014
Objectives: Quercetin and curcuminoids are important bioactive compounds found in many herbs. Previously reported high performance liquid chromatography ultraviolet (HPLC-UV) methods for the detection of quercetin and curcuminoids have several ...
Lee Fung Ang, Mun Fei Yam, Yvonne Tan Tze Fung, Peh Kok Kiang, Yusrida Darwin   +4 more
doaj   +1 more source

Shogaol, Bisdemethoxycurcumin, and Curcuminoid: Potential Zingiber Compounds Against COVID-19

Biointerface Research in Applied Chemistry, 2021
Coronavirus disease (COVID-19) is a global pandemic in the world. Some treatments, including vaccines and potential drugs, are still developed. This study investigated the bioactive compounds of Zingiber officinale, Kaempferia rotunda, and Curcuma zedoaria as a potential inhibitor for ACE2 and RdRP proteins. Molecular docking was used for screening the
openaire   +1 more source

Expression Levels of DNMT1, HDAC1, and MT1E Genes as Diagnostic Biomarkers for Breast Cancer Clinicopathological Features: In Vitro and In Silico Analyses

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Breast cancer (BC) is the second leading cause of cancer‐related deaths worldwide and has a high recurrence rate. This study aimed to evaluate the expression levels of three biomarkers: DNA methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), and metallothionein 1E (MT1E) in BC patients.
Sedigheh Akhtartavan, Hamid Madanchi, Raheb Ghorbani, Abolfazl Khalafi-Nezhad, Ahmad Abdullahi, Fahimeh Shamsi, Hossein Heli, Suraiya Saleem   +7 more
wiley   +1 more source

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

Journal of Pharmacological Sciences, 2018
The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity.
Yoichi Sunagawa, Masafumi Funamoto, Shogo Sono, Kana Shimizu, Satoshi Shimizu, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Eriko Morimoto, Morio Ueno, Maki Komiyama, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto   +14 more
doaj   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Bisdemethoxycurcumin, a curcumin, protects chondrocytes, and reduces cartilage inflammation via the NRF2/HO‐1/NLRP3 pathway

Immunity, Inflammation and Disease
Background The objective of this thesis is to evaluate the effect of bisdemethoxycurcumin (BDMC) on osteoarthritis (OA) and comprehensively evaluate the role of the Nuclear Factor erythroid 2‐Related Factor 2 (Nrf2) signalling pathway in chondrocytes ...
Gang Jin, Wei Xu, Huilin Tang, Yaying Cui, Han Zhang   +4 more
doaj   +1 more source

Simultaneous determination of three curcuminoids in Curcuma longa L. by high performance liquid chromatography coupled with electrochemical detection

Journal of Pharmaceutical Analysis, 2014
A novel method for analysis of three active components curcumin, demethoxycurcumin and bisdemethoxycurcumin in Curcuma longa L. was developed by HPLC coupled with electrochemical detection.
Yuling Long, Wenpeng Zhang, Fang Wang, Zilin Chen   +3 more
doaj   +1 more source