Combination Therapy of Bispecific Protein of Anti-PD-L1 Fused with TGF- β Receptor in Cancer
, 2022 Jianfei Yang
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Figure S4 from The PET-Tracer <sup>89</sup>Zr-Df-IAB22M2C Enables Monitoring of Intratumoral CD8 T-cell Infiltrates in Tumor-Bearing Humanized Mice after T-cell Bispecific Antibody Treatment [PDF]
, 2023 Christoph M. Griessinger +28 more
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Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
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OC41 - Glucocorticoid inhibition enables mono- and bispecific CAR-T cells to overcome immunotherapeutic resistance in adrenocortical carcinoma [PDF]
Marc Philipp Schauer +7 more
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Precision Radiation Oncology, EarlyView.The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song +5 more
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385 A bispecific engager-secreting TIL therapy designed to penetrate stromal barriers and boost tumor killing in solid tumors [PDF]
Jingwei Sun +7 more
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[Bispecific antibodies: what future?].
Medecine sciences : M/S, 2009 Monoclonal antibodies have emerged as a very successful class of therapeutic agents. In their native format, monoclonal antibodies are monospecific in that they recognize only one epitope, but their Fc domain also binds to FcfR-expressing cells. Attempts to improve the cytotoxicity of antibodies, particularly in the cancer field, have led to the design
Pèlegrin, André, Robert, Bruno
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CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada +13 more
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Real-world safety and mortality outcomes of CAR-T cell therapies versus bispecific antibodies in DLBCL: Insights from the faers database [PDF]
Fatma Temiz +2 more
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Acute myeloid leukemia targets for bispecific antibodies [PDF]
, 2017 Sayed Shahabuddin Hoseini +1 more
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