Results 1 to 10 of about 4,566 (189)

Evaluation of Multispecific Drugs Based on Patient‐Derived Immunocompetent Tumor Organoids

ChemBioChem
Zihan Zhao, Meng Zhou, Jie P Li
exaly  

Generating Multispecific Antibodies Through Column‐Based Redox Reactions: Part I

Biotechnology and Bioengineering
exaly  

Modular generation of multispecific antibodies using protein trans-splicing [PDF]

MAbs
Multispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
Jared A Shadish, John D Bagert, Amber Lee   +2 more
exaly   +5 more sources

The making of multispecific immunoglobulins – a clinical perspective [PDF]

MAbs
Over the past two decades, bi- and multispecific antibodies have emerged as a rapidly advancing class of therapeutic biologics, transforming oncology and immunotherapy.
Ulrich Brinkmann, Roland E Kontermann
exaly   +6 more sources

Developability considerations for bispecific and multispecific antibodies

MAbs
Bispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Raffi Tonikian
exaly   +6 more sources

Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics

Antibodies, 2021
Recombinant protein-based biotherapeutics drugs have transformed clinical pipelines of the biopharmaceutical industry since the launch of recombinant insulin nearly four decades ago. These biologic drugs are structurally more complex than small molecules,
Xiaotian Zhong, Aaron M D'Antona, Zhong Xiaotian   +2 more
exaly   +4 more sources

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

MAbs, 2020
Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per ...
Delphine Valente, Christine Mauriac, Thorsten Schmidt   +2 more
exaly   +4 more sources

Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics [PDF]

OncoImmunology
Over the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation.
Enfu Xue, Xiaolian Deng, Flora Doffe, Guido Kroemer, Oliver Kepp   +4 more
doaj   +3 more sources

Multispecific resistance of sheep trichostrongylids in Austria [PDF]

Parasite, 2021
Anthelmintic overuse and failure to implement methods preventing the development and spread of anthelmintic resistance (AR) have led to an alarming increase of resistant ovine trichostrongylids worldwide.
Untersweg Florian, Ferner Viktoria, Wiedermann Sandra, Göller Marie, Hörl-Rannegger Marion, Kaiser Waltraud, Joachim Anja, Rinaldi Laura, Krücken Jürgen, Hinney Barbara   +9 more
doaj   +7 more sources

Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study [PDF]

mAbs
The discovery and development of multispecific antibodies present unique challenges in optimizing their physicochemical properties to enhance developability and manufacturability.
Vanessa Siegmund, Daniel Klewinghaus, Jonas Teroerde, Lukas Pekar, Julia Harwardt, Stefan Zielonka, Francesca Militano, Giuseppe Licari, Andreas Evers   +8 more
doaj   +3 more sources