Modular generation of multispecific antibodies using protein trans-splicing [PDF]
MAbsMultispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
John Bagert, Jared A Shadish, Amber Lee
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Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics
Antibodies, 2021 Recombinant protein-based biotherapeutics drugs have transformed clinical pipelines of the biopharmaceutical industry since the launch of recombinant insulin nearly four decades ago. These biologic drugs are structurally more complex than small molecules,
Xiaotian Zhong, Aaron M D'Antona
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MAbs, 2020 Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per ...
Abdullah Kandira +2 more
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The making of multispecific immunoglobulins – a clinical perspective [PDF]
MAbsOver the past two decades, bi- and multispecific antibodies have emerged as a rapidly advancing class of therapeutic biologics, transforming oncology and immunotherapy.
Roland E Kontermann, Ulrich Brinkmann
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Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics [PDF]
OncoImmunologyOver the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation.
Enfu Xue +4 more
doaj +3 more sources
Developability considerations for bispecific and multispecific antibodies
MAbsBispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Patrick Farber, Raffi Tonikian
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Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study [PDF]
mAbsThe discovery and development of multispecific antibodies present unique challenges in optimizing their physicochemical properties to enhance developability and manufacturability.
Vanessa Siegmund +8 more
doaj +3 more sources
Codon deoptimization of multispecific biologics reduces mispairing during transient mammalian protein expression [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionCodon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant protein expression yields.
Timothy Z. Chang +10 more
doaj +2 more sources
Strategy for modular assembly of tetravalent, multispecific antibodies. [PDF]
Protein SciAbstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Mallette E +12 more
europepmc +2 more sources
PLoS ONE, 2014 Multispecific proteins play a major role in controlling various functions such as signaling, regulation of transcription/translation, and immune response. Hence, a thorough understanding of the atomic-level principles governing multispecific interactions
Oz Sharabi +5 more
doaj +2 more sources