Next generation Fc scaffold for multispecific antibodies [PDF]
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
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Developability considerations for bispecific and multispecific antibodies [PDF]
mAbsBispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Alaa Amash +9 more
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Modular generation of multispecific antibodies using protein trans-splicing [PDF]
mAbsMultispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
Jared A. Shadish +12 more
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Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models [PDF]
mAbs, 2020 Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per ...
Delphine Valente +12 more
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DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing [PDF]
Advanced Science, 2020 Targeting T‐cells against cancer cells is a direct means of treating cancer, and has already shown great responses in clinical treatment of B‐cell malignancies.
Liqiang Pan +4 more
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Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study [PDF]
mAbsThe discovery and development of multispecific antibodies present unique challenges in optimizing their physicochemical properties to enhance developability and manufacturability.
Vanessa Siegmund +8 more
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The making of multispecific immunoglobulins – a clinical perspective [PDF]
mAbsOver the past two decades, bi- and multispecific antibodies have emerged as a rapidly advancing class of therapeutic biologics, transforming oncology and immunotherapy.
Ulrich Brinkmann, Roland E. Kontermann
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Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation [PDF]
mAbsOn-target, off-tumor toxicities remain a major barrier for T-cell engagers in solid tumors. We present EVATM, a closed-loop design platform integrating high-throughput functional assays with multi-objective Bayesian optimization to explore combinatorial ...
Justin Grace +14 more
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Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics [PDF]
OncoImmunologyOver the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation.
Enfu Xue +4 more
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Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles. [PDF]
PLoS ONEMultispecific antibodies (MsAbs) enable the targeting of different epitopes, representing a strategy with enhanced therapeutic potential. However, the intracellular assembly of MsAbs is complex and generates unwanted mispaired species, imposing a ...
Catarina Melo +5 more
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