Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models [PDF]
mAbs, 2020 Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per ...
Delphine Valente +12 more
doaj +5 more sources
Modular generation of multispecific antibodies using protein trans-splicing [PDF]
mAbsMultispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
Jared A. Shadish +12 more
doaj +5 more sources
Developability considerations for bispecific and multispecific antibodies [PDF]
mAbsBispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Alaa Amash +9 more
doaj +5 more sources
Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study [PDF]
mAbsThe discovery and development of multispecific antibodies present unique challenges in optimizing their physicochemical properties to enhance developability and manufacturability.
Vanessa Siegmund +8 more
doaj +5 more sources
DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing [PDF]
Advanced Science, 2020 Targeting T‐cells against cancer cells is a direct means of treating cancer, and has already shown great responses in clinical treatment of B‐cell malignancies.
Liqiang Pan +4 more
doaj +3 more sources
Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation [PDF]
mAbsOn-target, off-tumor toxicities remain a major barrier for T-cell engagers in solid tumors. We present EVATM, a closed-loop design platform integrating high-throughput functional assays with multi-objective Bayesian optimization to explore combinatorial ...
Justin Grace +14 more
doaj +4 more sources
The making of multispecific immunoglobulins – a clinical perspective [PDF]
mAbsOver the past two decades, bi- and multispecific antibodies have emerged as a rapidly advancing class of therapeutic biologics, transforming oncology and immunotherapy.
Ulrich Brinkmann, Roland E. Kontermann
doaj +4 more sources
Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer [PDF]
International Journal of Molecular Sciences, 2021 Building upon the resounding therapeutic success of monoclonal antibodies, and supported by accelerating progress in engineering methods, the field of multispecific therapeutic antibodies is growing rapidly.
Petros Christopoulos, Hannah Schindler
exaly +3 more sources
Next generation Fc scaffold for multispecific antibodies [PDF]
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
doaj +2 more sources
Strategy for modular assembly of tetravalent, multispecific antibodies. [PDF]
Protein SciAbstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Mallette E +12 more
europepmc +2 more sources