Results 31 to 40 of about 487,050 (179)
Impact of Cistron Topology and Bicistronic Vector Design in the piggyBac Transposon System for Improved Antibody Expression. [PDF]
Biotechnol JGraphical Abstract and Lay Summary In this study, we systematically evaluated bicistronic vector designs within the piggyBac transposon system and identified that dual CMV promoters driving a Light chain‐GS‐Heavy chain configuration deliver optimal monoclonal antibody productivity.
Vitko J +10 more
europepmc +2 more sources
scFv-based biologics in diabetes: from therapeutic potential to clinical prospects [PDF]
Frontiers in ImmunologyThe global epidemic of diabetes mellitus the limitations of current therapies-including waning efficacy, adverse effects, and inability to modify disease progression-have accelerated the shift from conventional pharmacotherapy toward biologic agents ...
Shikun Ge +14 more
doaj +2 more sources
Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains. [PDF]
Sci Rep, 2016 Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen
Alvarez-Cienfuegos A +16 more
europepmc +2 more sources
Multispecific anti-idiotype monoclonal antibodies as immunoregulators
, 1997 Biotecnologia Aplicada 1997 Volume 14 No. 1, pp.46 Multispecific anti-idiotype monoclonal antibodies as immunoregulators Amparo Macias, Heidi Portuondo, Roberto Bolanos, Teresita Rodriguez, Consuelo Macias, Rolando Perez and Agustin Lage Code Number ...
core +5 more sources
Engineered mRNA and the Rise of Next-Generation Antibodies
Antibodies, 2021 Monoclonal antibodies are widely used as therapeutic agents in medicine. However, clinical-grade proteins require sophisticated technologies and are extremely expensive to produce, resulting in long lead times and high costs.
Laura Sanz, Luis Álvarez-Vallina
doaj +1 more source
Current landscape and future directions of bispecific antibodies in cancer immunotherapy
Frontiers in Immunology, 2022 Recent advances in cancer immunotherapy using monoclonal antibodies have dramatically revolutionized the therapeutic strategy against advanced malignancies, inspiring the exploration of various types of therapeutic antibodies.
Jing Wei +3 more
doaj +1 more source
Biomedicines, 2023 Monoclonal antibody-based therapy has shown efficacy against cancer, autoimmune, infectious, and inflammatory diseases. Multispecific antibodies (MsAbs), including trispecifics (tsAbs), offer enhanced therapeutic potential by targeting different epitopes.
Maria João Sebastião +7 more
doaj +1 more source
Emerging new therapeutic antibody derivatives for cancer treatment
Signal Transduction and Targeted Therapy, 2022 Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.
Shijie Jin +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf +2 more
doaj +1 more source
mAbs, 2021 Bispecific antibodies have recently attracted intense interest. CrossMab technology was described in 2011 as novel approach enabling correct antibody light-chain association with their respective heavy chain in bispecific antibodies, together with ...
Marlena Surowka +2 more
doaj +1 more source