Results 31 to 40 of about 2,301 (144)

Fc-competent multispecific PDL-1/TIGIT/LAG-3 antibodies potentiate superior anti-tumor T cell response

Scientific Reports, 2023
The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. The blockade of additional immune checkpoints,
Riyao Yang, Su Huang, Cai Huang, Nathan S. Fay, Yanan Wang, Saroja Putrevu, Kimberly Wright, Mohd Saif Zaman, Wenyan Cai, Betty Huang, Bo Wang, Meredith Wright, Matthew R. Hoag, Allison Titong, Yue Liu   +14 more
doaj   +1 more source

Engineering multi-specific antibodies against HIV-1

Retrovirology, 2018
As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse array of globally circulating HIV-1 strains ...
Neal N. Padte, Jian Yu, Yaoxing Huang, David D. Ho   +3 more
doaj   +1 more source

Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody

Frontiers in Immunology, 2023
To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules.
Julia Harwardt, Stefania C. Carrara, Stefania C. Carrara, Jan P. Bogen, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar, Harald Kolmar   +9 more
doaj   +1 more source

Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020) [PDF]

Advanced science, 2020
Nucleic acid–mediated protein–protein assembly (NAPPA) represents a true modular means for preparing multispecific antibodies (MsAbs). In article number https://doi.org/10.1002/advs.201900973, James J. Chou and co‐workers prepare MsAbs displaying T‐cell engaging and tumor killing properties in vivo.
Pan L, Cao C, Run C, Zhou L, Chou J.
europepmc   +3 more sources

Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies

mAbs, 2023
Upon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding.
Maria U. Johansson, Christopher Weinert, Dietrich Alexander Reichardt, Dana Mahler, Dania Diem, Christian Hess, Diana Feusi, Simon Carnal, Julia Tietz, Noreen Giezendanner, Fabio Mario Spiga, David Urech, Stefan Warmuth   +12 more
doaj   +1 more source

Broadly Protective Antibody-Like Vaccines Against Highly Pathogenic Coronaviruses. [PDF]

J Med Virol
ABSTRACT SARS‐CoV‐2 and MERS‐CoV are highly pathogenic and contagious coronaviruses. Despite intensive vaccination, SARS‐CoV‐2 continues to spread, and no FDA‐approved vaccines exist for MERS‐CoV; thus, more effective and safer vaccine options are needed. The receptor‐binding domain (RBD) of coronaviruses is a primary target of neutralizing antibodies (
Helal A, Aljehani ND, Ghazwani A, Alsulaiman RM, Alyami F, Abdulaal WH, Alsharef A, Alghanmi M, Zawawi A, Azhari AA, Almehmadi A, Balula J, Altorki T, Alhabbab RY, Khan MY, Alluhaybi K, Alnami A, Neamatallah T, Abujamel TS, Alfaleh MA, Hashem AM.   +20 more
europepmc   +2 more sources

Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics

mAbs, 2022
Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability.
Florian Heinkel, Meghan M. Verstraete, Siran Cao, Janessa Li, Patrick Farber, Elizabeth Stangle, Begonia Silva-Moreno, Fangni Peng, Surjit Dixit, Martin J. Boulanger, Thomas Spreter Von Kreudenstein, Eric Escobar-Cabrera   +11 more
doaj   +1 more source

Antibody Multispecificity Mediated by Conformational Diversity

Science, 2003
A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre–steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing ...
James L. C., Roversi P., Tawfik D. S.
openaire   +4 more sources

Immunopotentiating properties of a multispecific α-anti-idiotype antibody [PDF]

mAbs, 2012
Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly associated with the neutralization and clearance of antigens. Much less is known about the role of antibodies like these, based on their idiotypic connectivity. B7Y33 is a chimeric IgG1 version of
Tays, Hernández, Cristina, Mateo de Acosta, Rolando, Pérez   +2 more
openaire   +2 more sources

Antibody-Antibiotic Conjugates: Mechanisms, Clinical Progress, and Next-Generation Strategies Against Multidrug-Resistant Bacterial Infections. [PDF]

Microbiologyopen
Antibody–antibiotic conjugates enable targeted delivery of antibiotics to multidrug‐resistant bacteria by combining monoclonal antibody specificity with controlled intracellular drug release. This strategy improves efficacy against intracellular and biofilm‐associated infections while reducing systemic toxicity. ABSTRACT The rise of multidrug‐resistant
Askari P, Eshaghi S, Omidvar L, Mahi-Birjand M.   +3 more
europepmc   +2 more sources