Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc–FcγR complexes [PDF]
Nature CommunicationsThere is a strong need for multispecific antibodies that possess favorable clinical properties and can be generated through a simple and efficient process.
Miso Park +13 more
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Scientific Reports, 2023 The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. The blockade of additional immune checkpoints,
Riyao Yang +14 more
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Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics [PDF]
OncoImmunologyOver the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation.
Enfu Xue +4 more
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Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles. [PDF]
PLoS ONEMultispecific antibodies (MsAbs) enable the targeting of different epitopes, representing a strategy with enhanced therapeutic potential. However, the intracellular assembly of MsAbs is complex and generates unwanted mispaired species, imposing a ...
Catarina Melo +5 more
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What Does the Shape Space of T Cell Epitopes Look Like? [PDF]
Immunol RevABSTRACT Shape space is a decades‐old conceptual model of antibody–antigen interactions that underlies antigenic maps used to trace viral evolution. Here, we apply this concept to T cell receptors (TCRs) and the peptide–MHC complexes (pMHCs) that they recognize.
Buytenhuijs F, Schröder G, Textor J.
europepmc +2 more sources
Antibody engineering for SFTS treatment: frontier progress and translational challenges [PDF]
Frontiers in MicrobiologySevere Fever with Thrombocytopenia Syndrome (SFTS), a highly fatal tick-borne infectious disease caused by SFTS virus (SFTSV), currently lacks globally approved specific antiviral drugs or vaccines, although favipiravir was approved in Japan for SFTS ...
Xinhan Yu +4 more
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Bispecific and multispecific immune engagers for redirecting innate and adaptive immunity against hematologic cancers [PDF]
Discover OncologyBispecific antibodies (BsAbs) and multispecific antibodies (MsAbs) represent a transformative class of immunotherapeutics in oncology. These engineered molecules possess the unique ability to simultaneously target two or more distinct antigens, thereby ...
Mustafa T. Ardah +8 more
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Differential T cell reactivation by two PD-L1 nanobodies through blockade alone or blockade with internalization [PDF]
Scientific ReportsProgrammed death-ligand 1 (PD-L1) plays a key role in tumor immune evasion by suppressing T cell activity through its interaction with programmed death-1 (PD-1).
Ji Hyun Lee +3 more
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Toward Drug-Like Multispecific Antibodies by Design. [PDF]
Int J Mol Sci, 2020 The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions.
Sawant MS, Streu CN, Wu L, Tessier PM.
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Targeting angiogenesis: advances in the design and engineered applications of nanobodies [PDF]
Frontiers in ImmunologyAngiogenesis is a fundamental physiological process; however, its pathological dysregulation drives diseases such as solid tumors, wet age-related macular degeneration, and rheumatoid arthritis. Although clinically effective, conventional anti-angiogenic
Yuxuan Liu +4 more
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