Results 41 to 50 of about 4,566 (189)
Engineering multi-specific antibodies against HIV-1
Retrovirology, 2018 As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse array of globally circulating HIV-1 strains ...
Neal N. Padte +3 more
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Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors
Viruses, 2022 Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold. Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a ...
Marcel Walser +2 more
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Multispecificity of a recombinant anti‐ras monoclonal antibody [PDF]
Journal of Molecular Recognition, 2017 AbstractRecombinant monoclonal antibodies (Ab's) have widespread application as research tools, diagnostic reagents and as biotherapeutics. Whilst studying the cellular molecular switch protein m‐ras, a recombinant monoclonal antibody to m‐ras was generated for use as a research tool. Antibody genes from a single rabbit B cell secreting IgG to an m‐ras
John W. Schrader, Gary R. McLean
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Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes.
PLoS ONE, 2021 Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment.
Edit Szabó +8 more
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Antibody Multispecificity Mediated by Conformational Diversity
Science, 2003 A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre–steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing ...
James L. C., Roversi P., Tawfik D. S.
openaire +4 more sources
Intra-site differential inhibition of multi-specific enzymes
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The ability to catalyse a reaction acting on different substrates, known as “broad-specificity” or “multi-specificity”, and to catalyse different reactions at the same active site (“promiscuity”) are common features among the enzymes.
Mario Cappiello +4 more
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Structural and energetic aspects of multispecific immune recognition by NKG2D.
, 2003 The multispecific immune receptor NKG2D binds different ligands using a different set of energetically dominant interface residues for each ...
Jones, Edith +5 more
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mAbsThe development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic.
Michael Mullin +5 more
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Guiding the development of multispecific antibody-based cancer immunotherapies with 89Zr-immuno-PET imaging [PDF]
Antibody-based checkpoint inhibitors improved the treatment of patients with several tumor types. Several antibodies targeting immune checkpoints have been approved for the treatment of patients with cancers.
van Winkel, Claudia; id_orcid
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, 2019 FIGURE S3: Transduced targets for testing of multispecific CARs.
Paula L. Kosasih (14985828) +8 more
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