Results 41 to 50 of about 5,120 (192)
Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic
Angewandte Chemie, EarlyView.To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll +7 more
wiley +2 more sources
Computational and Structural Biotechnology Journal, 2020 Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf +2 more
doaj +1 more source
Aquaculture Nutrition, 2022 Macroalgae have been recently described as a potential ingredient for aquafeeds, exerting several physiological benefits. Grass carp (Ctenopharyngodon idella) is a freshwater species, which has been the major fish species produced in the world in the ...
Ana Galindo +9 more
doaj +1 more source
Multiple Paths to Multispecificity [PDF]
Immunity, 2006 The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.
openaire +2 more sources
, 2022 Supplementary Figure from A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor ...
Francesca Malvezzi (119984) +12 more
core +1 more source
Male genitalia of the species of the subfamily Agathidinae (Hymenoptera: Braconidae) and their importance in taxonomy [PDF]
Archives of Biological Sciences, 2010 A morphological analysis of the male genitalia of 24 species of the subfamily Agathidinae from 10 genera is presented. Detailed descriptions of important morphological features of all the species are given.
Brajković M. +5 more
doaj +1 more source
Engineering multi-specific antibodies against HIV-1
Retrovirology, 2018 As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse array of globally circulating HIV-1 strains ...
Neal N. Padte +3 more
doaj +1 more source
Multispecific anti-idiotype monoclonal antibodies as immunoregulators
, 1997 Biotecnologia Aplicada 1997 Volume 14 No. 1, pp.46 Multispecific anti-idiotype monoclonal antibodies as immunoregulators Amparo Macias, Heidi Portuondo, Roberto Bolanos, Teresita Rodriguez, Consuelo Macias, Rolando Perez and Agustin Lage Code Number ...
core +5 more sources
Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors
Viruses, 2022 Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold. Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a ...
Marcel Walser +2 more
doaj +1 more source
Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes.
PLoS ONE, 2021 Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment.
Edit Szabó +8 more
doaj +1 more source