Results 51 to 60 of about 3,462 (164)

The Role of γδ T Cells in Ischemic Stroke: Insights From the Perspective of the Brain–Gut Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
γδ T cells are pivotal in ischemic stroke, directly promoting brain inflammation and indirectly amplifying injury via the brain–gut axis. Through IL‐17 release, they disrupt the intestinal barrier, facilitating a harmful crosstalk that worsens stroke outcomes. Targeting this brain–gut immune axis presents a promising therapeutic strategy.
Yilin Li, Yina Li, Yang Shen, Yikun Gao, Jin Wang, Zhihong Jian, Lijuan Gu   +6 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

What Does the Shape Space of T Cell Epitopes Look Like?

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Shape space is a decades‐old conceptual model of antibody–antigen interactions that underlies antigenic maps used to trace viral evolution. Here, we apply this concept to T cell receptors (TCRs) and the peptide–MHC complexes (pMHCs) that they recognize.
Franka Buytenhuijs, Gijs Schröder, Johannes Textor   +2 more
wiley   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Affinity Enhancement in Discrete Multivalent MegaMolecules

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
We design discrete protein megamolecules with precisely controlled valency (1–6 nanobodies), which exhibit strong avidity‐driven affinity enhancement toward epidermal growth factor receptor and human epidermal growth factor receptor. We systematically investigate the roles of valency, intrinsic affinity, and spatial presentation in optimizing binding ...
Zhaoyi Gu, Blaise R. Kimmel, Justin A. Modica, Che‐Fan Huang, Rahul K. Salaria, Sraeyes Sridhar, Neil L. Kelleher, Milan Mrksich   +7 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Reproduction Pattern and Multispecific Spawning of Acropora spp. in Spermonde Islands Reef, Indonesia (Pola Reproduksi dan Pemijahan Multispecific Acropora Spp. di Kepulauan Spermonde, Indonesia)

Ilmu Kelautan, 2013
Perairan laut tropis seperti di Indonesia yang memiliki variasi lingkungan yang hampir konstan– diduga periode pemijahan karang melebar sampai beberapa bulan dan pada fase bulan yang berbeda, sehingga sulit menentukan waktu pemijahannya dalam skala bulan,
Syafyudin Yusuf, Jamaluddin Jompa, Neviaty P. Zamani, M. Zairin Junior   +3 more
doaj   +1 more source

Molecular Mechanism of Ochratoxin A Transport in the Kidney

Toxins, 2010
The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver.
Naohiko Anzai, Promsuk Jutabha, Hitoshi Endou   +2 more
doaj   +1 more source