Results 61 to 70 of about 3,462 (164)

Evolution of Multispecificity in an Immune Network [PDF]

, 1999
6 pages, 3 figures. latex.
Kouji Harada, Takashi Ikegami
openaire   +2 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing

Advanced Science, 2020
Targeting T‐cells against cancer cells is a direct means of treating cancer, and has already shown great responses in clinical treatment of B‐cell malignancies.
Liqiang Pan, Chan Cao, Changqing Run, Liujuan Zhou, James J. Chou   +4 more
doaj   +1 more source

Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc–FcγR complexes

Nature Communications
There is a strong need for multispecific antibodies that possess favorable clinical properties and can be generated through a simple and efficient process.
Miso Park, Kevin Ly, Bea Parcutela, Hyeran Choi, Carmina Ladra, Asaul Gonzalez, Yead Jewel, Hyunjun Kang, Melissa Valerio, Aparna Krishnan, Timothy W. Synold, Le Xuan Truong Nguyen, Guido Marcucci, John C. Williams   +13 more
doaj   +1 more source

CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions [PDF]

Brazilian Journal of Medical and Biological Research
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary immunotherapeutic strategy that has shown efficacy in hematological malignancies.
Weidong Li, Yueming Huang, Xinhao Zhou, Bohao Cheng, Haitao Wang, Yao Wang   +5 more
doaj   +1 more source

Engaging T cells for cleanup

Frontiers in Immunology
T-cell engagers represent a transformative approach to cancer immunotherapy leveraging bispecific and multispecific antibody constructs to redirect T-cell cytotoxicity toward malignant cells.
Roman V. Mungalov, Roman V. Mungalov, Roman V. Mungalov, Natalia V. Mushenkova, Natalia V. Mushenkova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Maria A. Turchaninova, Maria A. Turchaninova   +11 more
doaj   +1 more source

Design and Characterization of Bispecific and Trispecific Antibodies Targeting SARS-CoV-2

Vaccines
Background/Objectives: COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic since its outbreak in 2019. As an increasing number of variants have emerged, especially concerning variants such as Omicron BA.1, BA.2, XBB.1, EG.5, which can escape
Jiayang Wang, Qi Qian, Yushan Jiang, Zuxin Liang, Yun Peng, Wei Zhao, Yang Yang, Chenguang Shen   +7 more
doaj   +1 more source

Modular design of bi- and multi-specific knob domain fusions

Frontiers in Immunology
IntroductionThe therapeutic potential of bispecific antibodies is becoming widely recognised, with over a hundred formats already described. For many applications, enhanced tissue penetration is sought, so bispecifics with low molecular weight may offer ...
Mikhail Kuravsky, Glyn F. Gibbons, Callum Joyce, Anthony Scott-Tucker, Alex Macpherson, Alastair D. G. Lawson   +5 more
doaj   +1 more source

Sustained disease remission after a limited duration of bispecific antibody therapy in patients with multiple myeloma

HemaSphere, Volume 10, Issue 6, June 2026.
Gala Vega, Daniel Morillo, Christine Riedhammer, Febe Smits, Aishee Bag, Kelly Julian, Natalia Tovar Gomis, Carmen Montes Gaisan, Maria Aranzazu Bermudez, Mansi R. Shah, Ghulam Rehman Mohyuddin, Binod Dhakal, Leo Rasche, Carolina Schinke, Anita D'Souza, Aniko Szabo, Niels W. C. J. van de Donk, Rajshekhar Chakraborty, Meera Mohan   +18 more
wiley   +1 more source

Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

mAbs
Immunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication.
Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp   +9 more
doaj   +1 more source