Results 61 to 70 of about 4,566 (189)
Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
British Journal of Cancer, 1987 The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
openaire +2 more sources
Possible Gardens: cosmopolitical worlds
Frontiers in Environmental Science, 2023 This article presents some of the reflections produced by the Possible Gardens research, which explores the world of gardens where living beings interact directly, creating multispecific worlds.
Luciana Souza Bragança
doaj +1 more source
Affinity Enhancement in Discrete Multivalent MegaMolecules
ChemBioChem, Volume 27, Issue 11, 15 June 2026.We design discrete protein megamolecules with precisely controlled valency (1–6 nanobodies), which exhibit strong avidity‐driven affinity enhancement toward epidermal growth factor receptor and human epidermal growth factor receptor. We systematically investigate the roles of valency, intrinsic affinity, and spatial presentation in optimizing binding ...
Zhaoyi Gu +7 more
wiley +1 more source
, 2016 Thalamocortical (TC) input is a key determinant of the content and dynamics of information flow in the cerebral cortex. This input reaches the cortex via a diverse array of TC pathways, whose intricate and overlapping wiring architectures are not yet ...
Evangelio, Marian +4 more
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Multispecific synchronous coral spawning on Pulau Bidong, Malaysia, South China Sea
, 2020 [Extract] Multispecific synchronous spawning appears to be a feature of all speciose coral assemblages (Guest et al. 2005) having now been reported from at least 25 locations in the Indo-Pacific (Baird et al. 2015). Nonetheless, there are many aspects of
Samshuri, Muhammad' Arif +8 more
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Scientific Reports, 2023 The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. The blockade of additional immune checkpoints,
Riyao Yang +14 more
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VERITAS: Harnessing the power of nomenclature in biologic discovery
mAbs, 2023 We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision.
Riti Biswas +6 more
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Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, Volume 13, Issue 36, 29 June 2026.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Multispecific anti-idiotype monoclonal antibodies as immunoregulators
, 1997 Biotecnologia Aplicada 1997 Volume 14 No. 1, pp.46 Multispecific anti-idiotype monoclonal antibodies as immunoregulators Amparo Macias, Heidi Portuondo, Roberto Bolanos, Teresita Rodriguez, Consuelo Macias, Rolando Perez and Agustin Lage Code Number ...
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Current landscape and future directions of bispecific antibodies in cancer immunotherapy
Frontiers in Immunology, 2022 Recent advances in cancer immunotherapy using monoclonal antibodies have dramatically revolutionized the therapeutic strategy against advanced malignancies, inspiring the exploration of various types of therapeutic antibodies.
Jing Wei +3 more
doaj +1 more source