Results 61 to 70 of about 5,120 (192)

Multispecific synchronous coral spawning on Pulau Bidong, Malaysia, South China Sea

, 2020
[Extract] Multispecific synchronous spawning appears to be a feature of all speciose coral assemblages (Guest et al. 2005) having now been reported from at least 25 locations in the Indo-Pacific (Baird et al. 2015). Nonetheless, there are many aspects of
Samshuri, Muhammad' Arif, Noor, Mohammad Rafiq Hakimi Mohd, Baird, Andrew H., Kamarrudin, Nurzahirah, Zaidi, Puteri Nurshazmimi, Tan, Chun Hong, Jaafar, Siti NurTahirah, Safuan, Che Din Mohd, Idris, Izwandy   +8 more
core   +1 more source

Engineered mRNA and the Rise of Next-Generation Antibodies

Antibodies, 2021
Monoclonal antibodies are widely used as therapeutic agents in medicine. However, clinical-grade proteins require sophisticated technologies and are extremely expensive to produce, resulting in long lead times and high costs.
Laura Sanz, Luis Álvarez-Vallina
doaj   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

VERITAS: Harnessing the power of nomenclature in biologic discovery

mAbs, 2023
We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision.
Riti Biswas, Ed Belouski, Kevin Graham, Michelle Hortter, Marissa Mock, Christine E. Tinberg, Alan J. Russell   +6 more
doaj   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Anatomy and development of multispecific thalamocortical axons: Implications for cortical dynamics and evolution

, 2016
Thalamocortical (TC) input is a key determinant of the content and dynamics of information flow in the cerebral cortex. This input reaches the cortex via a diverse array of TC pathways, whose intricate and overlapping wiring architectures are not yet ...
Evangelio, Marian, Clasca Cabre, Francisco, Galazo, Maria José, Porrero Calzado, César, Rubio Garrido, José Pablo   +4 more
core   +1 more source

Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays [PDF]

, 2019
Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by immune-mediated muscular lesions that may be associated with extra-muscular manifestations involving skin, lungs, heart or joints.
Chen, Yi-Hsing, Damoiseaux, Jan, Bonroy, Carolien, Tseng, Chih-Wei, Vulsteke, Jean-Baptiste, De Langhe, Ellen, Platteel, Anouk C M, Hamann, Dörte, Piette, Yves, Bossuyt, Xavier, Shovman, Ora, Shoenfeld, Yehuda, Allenbach, Yves, Musset, Lucille   +13 more
core   +3 more sources

Fc-competent multispecific PDL-1/TIGIT/LAG-3 antibodies potentiate superior anti-tumor T cell response

Scientific Reports, 2023
The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. The blockade of additional immune checkpoints,
Riyao Yang, Su Huang, Cai Huang, Nathan S. Fay, Yanan Wang, Saroja Putrevu, Kimberly Wright, Mohd Saif Zaman, Wenyan Cai, Betty Huang, Bo Wang, Meredith Wright, Matthew R. Hoag, Allison Titong, Yue Liu   +14 more
doaj   +1 more source

Possible Gardens: cosmopolitical worlds

Frontiers in Environmental Science, 2023
This article presents some of the reflections produced by the Possible Gardens research, which explores the world of gardens where living beings interact directly, creating multispecific worlds.
Luciana Souza Bragança
doaj   +1 more source

Preclinical Target Animal Safety Evaluation of Veterinary Monoclonal Antibodies: Principles, Methods, and Interpretation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) represent a rapidly expanding pharmaceutical class in veterinary medicine, with several products now authorized for use in dogs and cats. Limited published articles and veterinarian exposure to the principles of drug development present challenges in interpreting published safety evaluations that inform product ...
Adam Werts, Matthew Kuhn, Lauren Bessey, Alicia Braxton Hickman, Emily Chory, John Mitchell, Kirby Pasloske   +6 more
wiley   +1 more source