Evolution of Multispecificity in an Immune Network [PDF]
, 1999 6 pages, 3 figures. latex.
Kouji Harada, Takashi Ikegami
openaire +2 more sources
Molecular Mechanism of Ochratoxin A Transport in the Kidney
Toxins, 2010 The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver.
Naohiko Anzai +2 more
doaj +1 more source
The Role of γδ T Cells in Ischemic Stroke: Insights From the Perspective of the Brain–Gut Axis
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.γδ T cells are pivotal in ischemic stroke, directly promoting brain inflammation and indirectly amplifying injury via the brain–gut axis. Through IL‐17 release, they disrupt the intestinal barrier, facilitating a harmful crosstalk that worsens stroke outcomes. Targeting this brain–gut immune axis presents a promising therapeutic strategy.
Yilin Li +6 more
wiley +1 more source
Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]
, 2002 Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T. +4 more
core +1 more source
Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
wiley +1 more source
, 1994 Bile is an important excretory route for the elimination of amphiphilic organic anions, and hepatocytes are the primary secretory units of bile formation.
JANSEN, PLM, ELFERINK, RPJO
core +1 more source
Frontiers in ImmunologyT-cell engagers represent a transformative approach to cancer immunotherapy leveraging bispecific and multispecific antibody constructs to redirect T-cell cytotoxicity toward malignant cells.
Roman V. Mungalov +11 more
doaj +1 more source
CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions [PDF]
Brazilian Journal of Medical and Biological ResearchChimeric antigen receptor (CAR) T-cell therapy is a revolutionary immunotherapeutic strategy that has shown efficacy in hematological malignancies.
Weidong Li +5 more
doaj +1 more source
Type 1 CD4+ T-cell help is required for induction of antipeptide multispecific cytotoxic T lymphocytes by a lipopeptide vaccine in rhesus macaques. [PDF]
, 1999 We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus ...
Lorenzo Mortara +11 more
core +1 more source
Design and Characterization of Bispecific and Trispecific Antibodies Targeting SARS-CoV-2
VaccinesBackground/Objectives: COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic since its outbreak in 2019. As an increasing number of variants have emerged, especially concerning variants such as Omicron BA.1, BA.2, XBB.1, EG.5, which can escape
Jiayang Wang +7 more
doaj +1 more source