Results 101 to 110 of about 5,120 (192)

Temporal variability of a protected multispecific tropical seagrass meadow in response to environmental change

, 2019
In a changing environment, there is an increasing interest to monitor ecosystems to understand their responses to environmental change. Seagrass meadows are highly important ecosystems that are under constant pressure from human activities and climate ...
Gullström, Martin,, Linderholm, Hans W.,, Eklöf, J. S.,, Nordlund, Lina M., Nordlund, L. M., Linderholm, H. W., Gullström, M., Eklöf, J. S., Gullström, M.,, Linderholm, H. W.,, Eklöf, Johan S.,, Aller, E. Alonso, Aller, E. Alonso,, Nordlund, Lina M.,, Kloiber, U.,, Kloiber, U., Alonso Aller, E., Alonso Aller, Elisa,   +17 more
core   +1 more source

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

, 1999
Recently, we isolated the multispecific organic anion transporter (OAT1) from the rat kidney, which plays important roles in the renal elimination of endogenous and exogenous organic anions including clinically important drugs.
Makoto Hosoyamada, Takashi Sekine, Hitoshi Endou, Yoshikatsu Kanai   +3 more
core   +1 more source

Designing Multivalent and Multispecific Biologics

Annual Review of Chemical and Biomolecular Engineering
In the era of precision medicine, multivalent and multispecific therapeutics present a promising approach for targeted disease intervention. These therapeutics are designed to interact with multiple targets simultaneously, promising enhanced efficacy, reduced side effects, and resilience against drug resistance.
Jennifer J, Kang, Ayako, Ohoka, Casim A, Sarkar   +2 more
openaire   +2 more sources

In vitro production of multimeric and multispecific nanobodies with the peptidisc technology

Nanobodies (nAbs) are emerging as potent alternatives over traditional antibodies, offering advantages in production efficiency, cost and reactivity.
Chen, Yilun
core   +1 more source

Bispecific and trispecific antibodies in atopic dermatitis: a review of the emerging clinical pipeline

Frontiers in Drug Discovery
Biologic therapies have reshaped treatment of atopic dermatitis, yet most available agents target only one cytokine or receptor and many patients still do not reach minimal disease activity.
Gili Amid-Toby, Omar Alani, Christopher G. Bunick   +2 more
doaj   +1 more source

Production, purification, and functional analysis of an artificial, multispecific protein based on an avidin scaffold

, 2015
Engineered, multispecific proteins show promise for many biological applications such as biosensors, immunotherapy targeting, and imaging and have advantages over multispecific antibodies since they are smaller and more stable.
Kurtzeborn, Kristen
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Rethinking Monospecific Antibody Therapy in Chronic Rhinosinusitis with Nasal Polyps: Dual- and Multispecific Antibodies. [PDF]

Clin Rev Allergy Immunol
Dai Y, Guo T, Shi M, Wang D, Wang M.
europepmc   +1 more source

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

, 1997
A novel multispecific organic anion transporting polypeptide (oatp2) has been isolated from rat brain. The cloned cDNA contains 3,640 bp. The coding region extends over 1,983 nucleotides, thus encoding a polypeptide of 661 amino acids.
Hagenbuch, B., Stieger, B., Meier, P. J., Noé, B.   +3 more
core  

Targeting angiogenesis: advances in the design and engineered applications of nanobodies. [PDF]

Front Immunol
Liu Y, Li Z, Ma Y, Liu Y.
europepmc   +1 more source

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen
Cuesta, Angel M., Blanco-Toribio, Ana, Merino, Nekane, Oliva Miguel, Baldomero, Harwood, Seandean Lykke, Mølgaard, Kasper, Blanco, Francisco, Navarro, Rocio, Villate, Maider, Compte, Marta, Bonet Martínez, Jaume, 1982-, Muñoz-Briones, Clara, Sørensen, Karen Marie Juul, Sanz, Laura, Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Alvarez-Vallina, Luis   +16 more
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