Results 101 to 110 of about 4,566 (189)

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

, 1999
Recently, we isolated the multispecific organic anion transporter (OAT1) from the rat kidney, which plays important roles in the renal elimination of endogenous and exogenous organic anions including clinically important drugs.
Makoto Hosoyamada, Takashi Sekine, Hitoshi Endou, Yoshikatsu Kanai   +3 more
core   +1 more source

Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

mAbs
Immunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication.
Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp   +9 more
doaj   +1 more source

DNA Vaccination of Macaques with Several Different Nef Sequences Induces Multispecific T Cell Responses

, 2001
CD8+ T lymphocytes play a key role in controlling viremia during primary human immunodeficiency virus-1 and in maintaining disease-free infection. It has recently been shown that DNA immunization of rhesus monkeys can elicit strong, long-lived antigen ...
Jean-Gérard Guillet, Isabelle Couillin, Martinon, Frédéric, Couillin, Isabelle, Franck Letourneur, Guillet, Jean-Gérard, Philippe Lefèbvre, Letourneur, Franck, Lefèbvre, Philippe, Frédéric Martinon   +9 more
core   +1 more source

mRNA-mediated delivery of anti-HIV-1 multispecific antibodies as a passive immunisation strategy

A research report submitted in fulfillment of the requirements for the Master of Science in Medicine, in the Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, 2024HIV-1 broadly neutralising antibodies (bNAbs)
O’Connor, Caitlyn
core  

Multispecific drugs: the fourth wave of biopharmaceutical innovation [PDF]

Signal Transduction and Targeted Therapy, 2020
Wang, Yifei, Yang, Shengyong
openaire   +2 more sources

Habitat use of a multispecific seagrass meadow by green turtles Chelonia mydas at Mayotte island

, 2010
International audienceWe investigated the habitat use in green turtles exploiting a 13-ha multispecific seagrass meadow at Mayotte Island, south-western Indian Ocean.
Grizel, Henri, Enstipp, Manfred, Henri Grizel, Georges, Jean-Yves, Stéphane Ciccione, Ciccione, Stéphane, Bourjea, Jérôme, Ballorain, Katia, Manfred Enstipp, Jean-Yves Georges, Jérôme Bourjea, Katia Ballorain   +11 more
core   +1 more source

Rapid affinity-based purification of multi-specific antibodies using Kappa Select and Protein L

mAbs
Multispecific antibodies (msAbs) are becoming more prevalent as formats of choice for therapeutic antibody development due to their ability to modulate multiple biological targets.
Kalie Mix, Tingwan Sun, Brian Hall, Jocelyn Newton, Christina Eng, Yongjing Guo, David Reczek   +6 more
doaj   +1 more source

Production, purification, and functional analysis of an artificial, multispecific protein based on an avidin scaffold

, 2015
Engineered, multispecific proteins show promise for many biological applications such as biosensors, immunotherapy targeting, and imaging and have advantages over multispecific antibodies since they are smaller and more stable.
Kurtzeborn, Kristen
core  

In vitro production of multimeric and multispecific nanobodies with the peptidisc technology

Nanobodies (nAbs) are emerging as potent alternatives over traditional antibodies, offering advantages in production efficiency, cost and reactivity.
Chen, Yilun
core  

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

, 1997
A novel multispecific organic anion transporting polypeptide (oatp2) has been isolated from rat brain. The cloned cDNA contains 3,640 bp. The coding region extends over 1,983 nucleotides, thus encoding a polypeptide of 661 amino acids.
Hagenbuch, B., Stieger, B., Meier, P. J., Noé, B.   +3 more
core