Results 91 to 100 of about 4,566 (189)

Type 1 CD4+ T-cell help is required for induction of antipeptide multispecific cytotoxic T lymphocytes by a lipopeptide vaccine in rhesus macaques. [PDF]

, 1999
We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus ...
Lorenzo Mortara, C. ROMMENS, I. BOURGAULT VILLADA, Isabelle Bourgault-Villada, Alain Venet, H. GRAS MASSE, MORTARA, LORENZO, A. VENET, J. G. GUILLET, Helene Gras-Masse, Jean-Gerard Guillet, Corinne Rommens   +11 more
core   +1 more source

[Multispecific monoclonal antibodies].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1992
Immunization of BALB/c mice with Rickettsia prowazekii antigens, Bordetella pertussis toxin and Legionella pneumophila cytolysin induces the synthesis of IgM autoantibodies of different specificity. Among monoclonal antibodies, multispecific antibodies with a wide reactivity spectrum have been found to make up high percentage (30-80%).
E I, Drobyshevskaia, S V, Spitsyn, Iu A, Nedialkov, V G, Nesterenko   +3 more
openaire   +1 more source

CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions [PDF]

Brazilian Journal of Medical and Biological Research
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary immunotherapeutic strategy that has shown efficacy in hematological malignancies.
Weidong Li, Yueming Huang, Xinhao Zhou, Bohao Cheng, Haitao Wang, Yao Wang   +5 more
doaj   +1 more source

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

, 2016
Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen
Cuesta, Angel M., Blanco-Toribio, Ana, Merino, Nekane, Oliva Miguel, Baldomero, Harwood, Seandean Lykke, Mølgaard, Kasper, Blanco, Francisco, Navarro, Rocio, Villate, Maider, Compte, Marta, Bonet Martínez, Jaume, 1982-, Muñoz-Briones, Clara, Sørensen, Karen Marie Juul, Sanz, Laura, Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Alvarez-Vallina, Luis   +16 more
core   +1 more source

Engaging T cells for cleanup

Frontiers in Immunology
T-cell engagers represent a transformative approach to cancer immunotherapy leveraging bispecific and multispecific antibody constructs to redirect T-cell cytotoxicity toward malignant cells.
Roman V. Mungalov, Roman V. Mungalov, Roman V. Mungalov, Natalia V. Mushenkova, Natalia V. Mushenkova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Maria A. Turchaninova, Maria A. Turchaninova   +11 more
doaj   +1 more source

Design and Characterization of Bispecific and Trispecific Antibodies Targeting SARS-CoV-2

Vaccines
Background/Objectives: COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic since its outbreak in 2019. As an increasing number of variants have emerged, especially concerning variants such as Omicron BA.1, BA.2, XBB.1, EG.5, which can escape
Jiayang Wang, Qi Qian, Yushan Jiang, Zuxin Liang, Yun Peng, Wei Zhao, Yang Yang, Chenguang Shen   +7 more
doaj   +1 more source

Modular design of bi- and multi-specific knob domain fusions

Frontiers in Immunology
IntroductionThe therapeutic potential of bispecific antibodies is becoming widely recognised, with over a hundred formats already described. For many applications, enhanced tissue penetration is sought, so bispecifics with low molecular weight may offer ...
Mikhail Kuravsky, Glyn F. Gibbons, Callum Joyce, Anthony Scott-Tucker, Alex Macpherson, Alastair D. G. Lawson   +5 more
doaj   +1 more source

The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man [PDF]

, 1997
The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of many endogenous and xenobiotic compounds. A similar disease phenotype has
Oude Elferink, R. P., Paulusma, C.C., Oude Elferink, R.P.J., Paulusma, C. C.   +3 more
core   +1 more source

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome [PDF]

, 1997
The human Dubin-Johnson syndrome (DJS) is a rare autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of non-bile salt organic anions.
Scheffer, G.L., Scheffer, G. L., Elferink, P.J.O., Scheper, R. J., Paulusma, C.C., Kool, M., Paulusma, C. C., Bosma, P. J., Terborg, F., Baas, F., Bosma, P.J., Oude Elferink, R. P., Tytgat, G.N.J., Scheper, R.J., ter Borg, F., Borst, P., Oude Elferink, R.P.J., Tytgat, G. N.   +17 more
core   +1 more source

Temporal variability of a protected multispecific tropical seagrass meadow in response to environmental change

, 2019
In a changing environment, there is an increasing interest to monitor ecosystems to understand their responses to environmental change. Seagrass meadows are highly important ecosystems that are under constant pressure from human activities and climate ...
Gullström, Martin,, Linderholm, Hans W.,, Eklöf, J. S.,, Nordlund, Lina M., Nordlund, L. M., Linderholm, H. W., Gullström, M., Eklöf, J. S., Gullström, M.,, Linderholm, H. W.,, Eklöf, Johan S.,, Aller, E. Alonso, Aller, E. Alonso,, Nordlund, Lina M.,, Kloiber, U.,, Kloiber, U., Alonso Aller, E., Alonso Aller, Elisa,   +17 more
core   +1 more source