Results 91 to 100 of about 5,120 (192)
DNA Vaccination of Macaques with Several Different Nef Sequences Induces Multispecific T Cell Responses [PDF]
, 2001 CD8+ T lymphocytes play a key role in controlling viremia during primary human immunodeficiency virus-1 and in maintaining disease-free infection. It has recently been shown that DNA immunization of rhesus monkeys can elicit strong, long-lived antigen ...
Jean-Gérard Guillet +9 more
core +1 more source
Modular design of bi- and multi-specific knob domain fusions
Frontiers in ImmunologyIntroductionThe therapeutic potential of bispecific antibodies is becoming widely recognised, with over a hundred formats already described. For many applications, enhanced tissue penetration is sought, so bispecifics with low molecular weight may offer ...
Mikhail Kuravsky +5 more
doaj +1 more source
Mechanisms of Substrate Recognition by the Multispecific Protein Lysine Methyltransferase SETD6
LifeThe SETD6 protein lysine methyltransferase monomethylates specific lysine residues in a diverse set of substrates which contain the target lysine residue in a highly variable amino acid sequence context.
Gizem T. Ulu +6 more
doaj +1 more source
, 2016 Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen
Cuesta, Angel M. +16 more
core +1 more source
Potential of alarmin-targeted bispecific and combination therapies in airway disease
Frontiers in AllergyThymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
doaj +1 more source
Rigidly connected multispecific artificial binders with adjustable geometries [PDF]
, 2017 Multivalent binding proteins can gain biological activities beyond what is inherent in the individual binders, by bringing together different target molecules, restricting their conformational flexibility or changing their subcellular localization.
Wu, Yufan +5 more
core +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Abstract A020: Engineering developability of anti-CD3 scFv-based multispecific T-cell engagers
Multispecific T-cell engager antibody assembly requires solutions to avoid non-cognate chain-pairing. The single-chain fragment variable (scFv) format solves the LC pairing problem, however biophysical properties are usually significantly inferior to Fab-
Kevin Schutz +5 more
core +1 more source
mRNA-mediated delivery of anti-HIV-1 multispecific antibodies as a passive immunisation strategy
A research report submitted in fulfillment of the requirements for the Master of Science in Medicine, in the Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, 2024HIV-1 broadly neutralising antibodies (bNAbs)
O’Connor, Caitlyn
core
Trispecific SEED antibodies engineered for neutrophil-mediated cell killing
mAbsImmunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication.
Veronica Natale +9 more
doaj +1 more source