Results 71 to 80 of about 4,566 (189)

Designing Multivalent and Multispecific Biologics

Annual Review of Chemical and Biomolecular Engineering
In the era of precision medicine, multivalent and multispecific therapeutics present a promising approach for targeted disease intervention. These therapeutics are designed to interact with multiple targets simultaneously, promising enhanced efficacy, reduced side effects, and resilience against drug resistance.
Jennifer J, Kang, Ayako, Ohoka, Casim A, Sarkar   +2 more
openaire   +2 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Multispecific lymphoid cell surface receptors. [PDF]

Proceedings of the National Academy of Sciences, 1977
When mice are sequentially immunized with two antigens to give an oligoclonal "double-binding" antibody response, there is a concomitant increase of "double-binding" cell surface receptors on their splenic lymphocytes. Competition studies suggest that the capacity to bind the two ligands, bovine pancreatic ribonuclease (EC 3.1.4.22) and a 2,4 ...
M J, Czaja, F F, Richards, J M, Varga
openaire   +2 more sources

The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells. [PDF]

The prognosis of patients with acute myeloid leukemia (AML) is limited, especially for elderly or unfit patients not eligible for hematopoietic stem cell (HSC) transplantation.
Iss, Chloé, Riether, Carsten, Spitzli, Patricia, Reichen, Christian, Fischer, Stefanie, Schlegel, Iris, Looser, Thamar, Eggenschwiler, Aline, Neculcea, Alexandra, Franchini, Marco, Kirkin, Vladimir, Grübler, Yvonne, Croset, Amelie, Wullschleger, Stephan, Matzner, Mirela, Kaufmann, Yvonne, Marpakwar, Rajlakshmi, Villemagne, Denis, Schiegg, Dieter, Bianchi, Matteo, Ali, Waleed, Ochsenbein, Adrian F, Lüthi, Ursina, Reschke, Nina, Hänggi, Martin, Frasconi, Teresa M, Abduli, Liridon, Schlereth, Bernd, Steiner, Daniel, Herzog, Christel, Dawson, Keith M, Zitt, Christof, Auge, Alienor, Grimm, Sebastian, Leupin, Nicolas, Ragusa, Simone, Lekishvili, Tamara, Goubier, Anne   +37 more
core   +1 more source

Environmental influence on intraspecific trait variation in the tropical seagrass Halodule uninervis

Oikos, Volume 2026, Issue 6, June 2026.
Intraspecific trait variation (ITV) enhances the precision of applying functional trait approaches in plant ecology. Despite its benefits, ITV is rarely considered in functional trait‐based seagrass research. The goal of our research is to measure ITV in the tropical seagrass species Halodule uninervis and assess the environmental factors associated ...
Chieh Lin, Michael A. Rasheed, Robert G. Coles, Paul H. York, Stephen Lewis, Alana Grech   +5 more
wiley   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors

, 2019
PURPOSE The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity.
Rajan, Anusha, Plückthun, Andreas; https://orcid.org/, Jensen, Michael C, Balakrishnan, Ashwini, Kosasih, Paula L, Wu, Qian, Riddell, Stanley R, Voutsinas, Jenna, Salter, Alexander I; https://orcid.org/   +8 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, Volume 16, Issue 5, Page 1030-1043, May 2026.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]

, 2002
Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T., Hagenbuch, B., Ugele, B., Meier, P. J., St-Pierre, M. V.   +4 more
core   +1 more source

Orthogonal Tri‐Modular Coiled‐Coil Assembly for Programmable Multi‐Cargo Display on Escherichia coli Nissle 1917

Small, Volume 22, Issue 28, 18 May 2026.
A tri‐specific scaffold cell (TriSC) platform is engineered to enable programmable, reversible, and multiplex surface assembly through orthogonal and spontaneous coiled‐coil interactions. Independent targeting and therapeutic nanobodies are modularly recruited onto bacterial surfaces, allowing tunable combinatorial functionality.
Yong Joon Cho, Gyu‐Jin Lee, Jong‐Ha Park, Sung In Lim   +3 more
wiley   +1 more source