Results 71 to 80 of about 5,120 (192)

Current landscape and future directions of bispecific antibodies in cancer immunotherapy

Frontiers in Immunology, 2022
Recent advances in cancer immunotherapy using monoclonal antibodies have dramatically revolutionized the therapeutic strategy against advanced malignancies, inspiring the exploration of various types of therapeutic antibodies.
Jing Wei, Yueyao Yang, Gang Wang, Ming Liu   +3 more
doaj   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors

, 2019
PURPOSE The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity.
Rajan, Anusha, Plückthun, Andreas; https://orcid.org/, Jensen, Michael C, Balakrishnan, Ashwini, Kosasih, Paula L, Wu, Qian, Riddell, Stanley R, Voutsinas, Jenna, Salter, Alexander I; https://orcid.org/   +8 more
core   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Principles for the design of multispecific proteins

OnlinePublMultispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid ...
Devkota, S.R., Aryal, P., Kunwar, S., Stone, M.J., Bhusal, R.P., Bell, M.   +5 more
core   +1 more source

The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells. [PDF]

The prognosis of patients with acute myeloid leukemia (AML) is limited, especially for elderly or unfit patients not eligible for hematopoietic stem cell (HSC) transplantation.
Iss, Chloé, Riether, Carsten, Spitzli, Patricia, Reichen, Christian, Fischer, Stefanie, Schlegel, Iris, Looser, Thamar, Eggenschwiler, Aline, Neculcea, Alexandra, Franchini, Marco, Kirkin, Vladimir, Grübler, Yvonne, Croset, Amelie, Wullschleger, Stephan, Matzner, Mirela, Kaufmann, Yvonne, Marpakwar, Rajlakshmi, Villemagne, Denis, Schiegg, Dieter, Bianchi, Matteo, Ali, Waleed, Ochsenbein, Adrian F, Lüthi, Ursina, Reschke, Nina, Hänggi, Martin, Frasconi, Teresa M, Abduli, Liridon, Schlereth, Bernd, Steiner, Daniel, Herzog, Christel, Dawson, Keith M, Zitt, Christof, Auge, Alienor, Grimm, Sebastian, Leupin, Nicolas, Ragusa, Simone, Lekishvili, Tamara, Goubier, Anne   +37 more
core   +2 more sources

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

Reproduction Pattern and Multispecific Spawning of Acropora spp. in Spermonde Islands Reef, Indonesia (Pola Reproduksi dan Pemijahan Multispecific Acropora Spp. di Kepulauan Spermonde, Indonesia)

Ilmu Kelautan, 2013
Perairan laut tropis seperti di Indonesia yang memiliki variasi lingkungan yang hampir konstan– diduga periode pemijahan karang melebar sampai beberapa bulan dan pada fase bulan yang berbeda, sehingga sulit menentukan waktu pemijahannya dalam skala bulan,
Syafyudin Yusuf, Jamaluddin Jompa, Neviaty P. Zamani, M. Zairin Junior   +3 more
doaj   +1 more source