Results 31 to 40 of about 4,566 (189)
Next generation of multispecific antibody engineering
Antibody Therapeutics, 2023 Abstract Multispecific antibodies recognize two or more epitopes located on the same or distinct targets. This added capability through protein design allows these man-made molecules to address unmet medical needs that are no longer possible with single targeting such as with monoclonal antibodies or cytokines alone.
Daniel Keri +4 more
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Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics
mAbs, 2022 Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability.
Florian Heinkel +11 more
doaj +1 more source
Multiple Paths to Multispecificity [PDF]
Immunity, 2006 The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.
openaire +2 more sources
Elucidating the Mechanism of Multispecific Antibody Aggregation through Subunit Analysis
, 2023 Multispecific antibody constructs are quickly becoming more common constructs in biopharmaceuticals to improve specificity and efficacy. While the advent of this technology has led to improved therapeutics, its development has challenged the analytical ...
Eric Beil (17335121) +7 more
core +1 more source
Evolution of Multispecificity in an Immune Network [PDF]
, 1999 6 pages, 3 figures. latex.
Kouji Harada, Takashi Ikegami
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Cell Death and Disease, 2022 Chimeric antigen receptor (CAR)-T cells directed to solid tumors have been less effective, due in part to the low or lost expression of specific tumor antigens.
Ting Sun +5 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf +2 more
doaj +1 more source
Aquaculture Nutrition, 2022 Macroalgae have been recently described as a potential ingredient for aquafeeds, exerting several physiological benefits. Grass carp (Ctenopharyngodon idella) is a freshwater species, which has been the major fish species produced in the world in the ...
Ana Galindo +9 more
doaj +1 more source
, 2022 Supplementary Figure from A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor ...
Francesca Malvezzi (119984) +12 more
core +1 more source
Male genitalia of the species of the subfamily Agathidinae (Hymenoptera: Braconidae) and their importance in taxonomy [PDF]
Archives of Biological Sciences, 2010 A morphological analysis of the male genitalia of 24 species of the subfamily Agathidinae from 10 genera is presented. Detailed descriptions of important morphological features of all the species are given.
Brajković M. +5 more
doaj +1 more source