Results 31 to 40 of about 5,120 (192)
mAbs, 2022 Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva +9 more
doaj +1 more source
AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
mAbs, 2020 As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest.
Mario Sanches +13 more
doaj +1 more source
Next generation Fc scaffold for multispecific antibodies
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
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Structural and energetic aspects of multispecific immune recognition by NKG2D. [PDF]
, 2003 The multispecific immune receptor NKG2D binds different ligands using a different set of energetically dominant interface residues for each ...
Jones, Edith +5 more
core +1 more source
Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics
mAbs, 2022 Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability.
Florian Heinkel +11 more
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Elucidating the Mechanism of Multispecific Antibody Aggregation through Subunit Analysis
, 2023 Multispecific antibody constructs are quickly becoming more common constructs in biopharmaceuticals to improve specificity and efficacy. While the advent of this technology has led to improved therapeutics, its development has challenged the analytical ...
Eric Beil (17335121) +7 more
core +1 more source
Tradeoff between stability and multispecificity in the design of promiscuous proteins. [PDF]
PLoS Computational Biology, 2009 Natural proteins often partake in several highly specific protein-protein interactions. They are thus subject to multiple opposing forces during evolutionary selection.
Menachem Fromer, Julia M Shifman
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“Stapling” scFv for multispecific biotherapeutics of superior properties
mAbs, 2023 Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells.
Lauren E. Boucher +29 more
doaj +1 more source
Toward Drug-Like Multispecific Antibodies by Design
, 2020 The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions.
Manali S. Sawant +3 more
core +1 more source
Cell Death and Disease, 2022 Chimeric antigen receptor (CAR)-T cells directed to solid tumors have been less effective, due in part to the low or lost expression of specific tumor antigens.
Ting Sun +5 more
doaj +1 more source