Mechanisms of Substrate Recognition by the Multispecific Protein Lysine Methyltransferase SETD6 [PDF]
LifeThe SETD6 protein lysine methyltransferase monomethylates specific lysine residues in a diverse set of substrates which contain the target lysine residue in a highly variable amino acid sequence context.
Gizem T. Ulu +6 more
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Potential of alarmin-targeted bispecific and combination therapies in airway disease [PDF]
Frontiers in AllergyThymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
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Peptidoglycan Remodeling by the Coordinated Action of Multispecific Enzymes [PDF]
Microbial Drug Resistance, 2014 The peptidoglycan (PG) cell wall constitutes the main defense barrier of bacteria against environmental insults and acts as communication interface. The biochemistry of this macromolecule has been well characterized throughout the years but recent discoveries have unveiled its chemical plasticity under environmental stresses.
Álvarez, Laura +4 more
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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies [PDF]
Frontiers in Immunology, 2019 Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment.
Starlynn C. Clarke +21 more
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Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles. [PDF]
PLoS ONEMultispecific antibodies (MsAbs) enable the targeting of different epitopes, representing a strategy with enhanced therapeutic potential. However, the intracellular assembly of MsAbs is complex and generates unwanted mispaired species, imposing a ...
Catarina Melo +5 more
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Immune escape mechanism of B-cell malignancies on Anti-CD19 Chimeric Antigen Receptor T-cell treatment and solution [PDF]
E3S Web of Conferences, 2021 Relapse or refractory B-cell malignancies have been reported in multiple clinical trials after treatment of Anti-CD19 Chimeric Antigen Receptor (CAR) T-cells.
Qian Jin
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Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
mAbs, 2023 Upon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding.
Maria U. Johansson +12 more
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mAbs, 2023 A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller +6 more
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mAbs, 2022 Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva +9 more
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AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
mAbs, 2020 As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest.
Mario Sanches +13 more
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