Results 21 to 30 of about 3,462 (164)
Tradeoff between stability and multispecificity in the design of promiscuous proteins. [PDF]
PLoS Computational Biology, 2009 Natural proteins often partake in several highly specific protein-protein interactions. They are thus subject to multiple opposing forces during evolutionary selection.
Menachem Fromer, Julia M Shifman
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“Stapling” scFv for multispecific biotherapeutics of superior properties
mAbs, 2023 Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells.
Lauren E. Boucher +29 more
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Cell Death and Disease, 2022 Chimeric antigen receptor (CAR)-T cells directed to solid tumors have been less effective, due in part to the low or lost expression of specific tumor antigens.
Ting Sun +5 more
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Computational and Structural Biotechnology Journal, 2020 Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf +2 more
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Aquaculture Nutrition, 2022 Macroalgae have been recently described as a potential ingredient for aquafeeds, exerting several physiological benefits. Grass carp (Ctenopharyngodon idella) is a freshwater species, which has been the major fish species produced in the world in the ...
Ana Galindo +9 more
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PLoS ONE, 2014 Multispecific proteins play a major role in controlling various functions such as signaling, regulation of transcription/translation, and immune response. Hence, a thorough understanding of the atomic-level principles governing multispecific interactions
Oz Sharabi +5 more
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Multiple Paths to Multispecificity [PDF]
Immunity, 2006 The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.
openaire +2 more sources
Male genitalia of the species of the subfamily Agathidinae (Hymenoptera: Braconidae) and their importance in taxonomy [PDF]
Archives of Biological Sciences, 2010 A morphological analysis of the male genitalia of 24 species of the subfamily Agathidinae from 10 genera is presented. Detailed descriptions of important morphological features of all the species are given.
Brajković M. +5 more
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Engineering multi-specific antibodies against HIV-1
Retrovirology, 2018 As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse array of globally circulating HIV-1 strains ...
Neal N. Padte +3 more
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Frontiers in Bioengineering and BiotechnologyIntroductionCodon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant protein expression yields.
Timothy Z. Chang +10 more
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