Beyond IgE: Expanding Perspectives on Multiclass Immunoglobulin Responses in Anisakis Allergy [PDF]
Clin Case RepABSTRACT Anisakis allergy may involve antibody responses beyond IgE alone. Considering both mucosal and systemic immunoglobulin responses may improve our understanding of sensitization, immune regulation, and host–parasite interactions; although further studies are required before these observations can be translated into clinical practice.
Arunsan P +3 more
europepmc +2 more sources
Multispecific resistance of sheep trichostrongylids in Austria [PDF]
Parasite, 2021 Anthelmintic overuse and failure to implement methods preventing the development and spread of anthelmintic resistance (AR) have led to an alarming increase of resistant ovine trichostrongylids worldwide.
Untersweg Florian +9 more
doaj +3 more sources
Antineutrophil Cytoplasmic Autoantibodies Specific to Bactericidal/Permeability-Increasing Protein: A Cross-Road Between Prolonged Gram-Negative Bacterial Infections and Ulcerative Colitis/Primary Sclerosing Cholangitis [PDF]
DiagnosticsBackground/Objectives: Binding of bactericidal/permeability-increasing (BPI) protein to Gram-negative (GN) bacteria plays a major role in bacterial elimination.
Dragana Jovanovic +7 more
doaj +2 more sources
Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc–FcγR complexes [PDF]
Nature CommunicationsThere is a strong need for multispecific antibodies that possess favorable clinical properties and can be generated through a simple and efficient process.
Miso Park +13 more
doaj +2 more sources
Impact of Cistron Topology and Bicistronic Vector Design in the piggyBac Transposon System for Improved Antibody Expression. [PDF]
Biotechnol JGraphical Abstract and Lay Summary In this study, we systematically evaluated bicistronic vector designs within the piggyBac transposon system and identified that dual CMV promoters driving a Light chain‐GS‐Heavy chain configuration deliver optimal monoclonal antibody productivity.
Vitko J +10 more
europepmc +2 more sources
DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing
Advanced Science, 2020 Targeting T‐cells against cancer cells is a direct means of treating cancer, and has already shown great responses in clinical treatment of B‐cell malignancies.
James J Chou, Liqiang Pan, Chan Cao
exaly +2 more sources
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies [PDF]
Frontiers in Immunology, 2019 Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment.
Starlynn C. Clarke +21 more
doaj +2 more sources
Immune escape mechanism of B-cell malignancies on Anti-CD19 Chimeric Antigen Receptor T-cell treatment and solution [PDF]
E3S Web of Conferences, 2021 Relapse or refractory B-cell malignancies have been reported in multiple clinical trials after treatment of Anti-CD19 Chimeric Antigen Receptor (CAR) T-cells.
Qian Jin
doaj +1 more source
Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
mAbs, 2023 Upon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding.
Maria U. Johansson +12 more
doaj +1 more source
mAbs, 2023 A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller +6 more
doaj +1 more source