Results 81 to 90 of about 38,450 (306)
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy
, 2018 Haitao Pan,1,2 Jiayu Liu,1,2 Wentong Deng,1,2 Jieyu Xing,1,2 Qing Li,1,2 Zhong Wang1,2 1School of Pharmaceutical Sciences, 2Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, People’s Republic of China Introduction ...
Pan H +5 more
core
Bispecific monoclonal antibodies
, 2023 Bispecifična monoklonska protitelesa (bsMAb) so beljakovine, ki se lahko vežejo na dve različni mesti za vezavo antigenov v eni molekuli. S hkratnim prepoznavanjem dveh različnih tarč lahko bispecifična protitelesa zavirajo dve signalni poti, tako da so ...
Matov, Matea
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Biopharmaceutics &Drug Disposition, EarlyView.This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri +6 more
wiley +1 more source
Acta Haematologica Oncologica TurcicaAim: This study aimed to assess the real-world performance of elranatamab in terms of its effectiveness, safety, and tolerability among patients diagnosed with triple-class refractory-multiple myeloma (TCR-MM) who have undergone extensive prior treatment.
Ant Uzay
doaj +1 more source
Homogeneous Bispecifics by Disulfide Bridging
Bioconjugate Chemistry, 2014 We report on a chemical platform to generate site-specific, homogeneous, antibody-antibody conjugates by targeting and bridging disulfide bonds. A bispecific antibody construct was produced in good yield through simple reduction and bridging of antibody fragment disulfide bonds, using a readily synthesized bis-dibromomaleimide cross-linker.
Hull, Elizabeth A. +5 more
openaire +2 more sources
Purification of anti-BSA-digoxin bispecific antibodies.
, 2013 Anti-BSA-digoxin bispecific antibodies were purified from the serum using a series of purification methods. IgG fraction was obtained using 50% saturated ammonium sulfate precipitation, followed by passing through a protein A column.
Jinming Li (128865) +2 more
core +1 more source
The emergence of bispecific antibodies as novel cancer therapeutics [PDF]
, 2023 Bispecific antibodies have recently taken the immune-oncology field by storm through its multi-targeting capabilities and unique mechanisms of action. In the past few decades, this therapeutic format has seen an exponential rise, and with every year, new
Li, Robert
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Biotechnology and Bioengineering, EarlyView.ABSTRACT The biopharmaceutical industry increasingly relies on single‐use technologies (SUT) for operational flexibility. For a long time, SUT was considered more sustainable than stainless‐steel (SST) systems due to water and energy savings. This study re‐evaluates this paradigm via a detailed bottom‐up analysis of the SUT carbon footprint at the 2000
Jan Reiners +4 more
wiley +1 more source
The Role of Tumor Microenvironment and Targeted Therapy in Chronic Lymphocytic Leukemia
Current Issues in Molecular BiologyChronic lymphocytic leukemia (CLL) is the most common leukemia in adults. It is characterized by the clonal proliferation of mature B cells. The tumor microenvironment (TME) seems to play a crucial role in the survival and proliferation of tumor cells ...
Khalil Saleh +13 more
doaj +1 more source
Performance of bispecific Abs and 2 Ab combinations involving bispecifics.
, 2018 (A-C) same as Fig 3A–3C, respectively, except combinations of both bispecific Abs and of the type bispecific + conventional Abs are considered. For combinations of 3BNC117-PGT135 bispecific with bnAbs, only V2 glycan bnAbs are considered to ensure non ...
David D. Ho (88133) +14 more
core +1 more source