Potential roles of antibodies with different classes in IgG4‐related diseases
Rheumatology &Autoimmunity, EarlyView.This review discussed the common characteristics of different classes of antibodies and their potential corresponding unique mechanisms involved in immunoglobulin G4‐related disease. Abstract Immunoglobulin G4‐related disease (IgG4‐RD), first identified two decades ago, is an immune‐mediated pro‐inflammatory and profibrotic disease entity affecting ...
Ling Li +6 more
wiley +1 more source
T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites [PDF]
, 2003 Shigeto Yoshida +6 more
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Large scale paired antibody language models [PDF]
arXivAntibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in ...
arxiv
A recombinant bispecific single‐chain antibody induces targeted, supra‐agonistic CD28‐stimulation and tumor cell killing [PDF]
, 2003 Ludger Große‐Hovest +5 more
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Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
VIEW, EarlyView.In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu +6 more
wiley +1 more source
Non-affinity platform for processing knob-into-hole bispecific antibody
Bioresources and BioprocessingBispecific antibodies hold significant potential as next-generation biotherapeutics owing to their ability to simultaneously bind to two targets. However, the development of bispecific antibodies as biotherapeutics has been hindered by the high levels of
Xiaoyang Wang +5 more
doaj +1 more source
ANTIPASTI: interpretable prediction of antibody binding affinity exploiting Normal Modes and Deep Learning [PDF]
arXivThe high binding affinity of antibodies towards their cognate targets is key to eliciting effective immune responses, as well as to the use of antibodies as research and therapeutic tools. Here, we propose ANTIPASTI, a Convolutional Neural Network model that achieves state-of-the-art performance in the prediction of antibody binding affinity using as ...
arxiv
Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody [PDF]
, 2004 Fabrice Le Gall +3 more
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Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope
Acta Crystallographica Section D, EarlyView.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li +7 more
wiley +1 more source