Results 181 to 190 of about 66,588 (284)

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

The Effects of Bone-Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX). [PDF]

Cancer Med
Im BH, Zarrabi KK, Hochberg AR, Shah MS, Mark JR, Izes JK, Gomella PT, Lallas CD, Gomella LG, Metwalli AR.   +9 more
europepmc   +1 more source

Clinical Presentation of the Longest Reported Living Individual With Bent Bone Dysplasia—FGFR2‐Related

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 728-732, March 2026.
ABSTRACT The FGFR2 gene, encoding the FGFR2 protein, plays a crucial role in embryonic cell development, particularly in bone tissue. Bent Bone Dysplasia (BBD), FGFR2‐related (MIM# 614592), is a rare severe skeletal dysplasia characterized by craniofacial differences, reduced bone mineral density, and bowed long bones.
Cheyenne Bates, Pardeep Gill, Matthew Choi, Frances Mahon, Blake Yarascavitch, Audrey Lim, Resham Ejaz   +6 more
wiley   +1 more source

Drug Coverage Policy and Legacy Prescribing: A Cross-Sectional Analysis in British Columbia. [PDF]

Health Sci Rep
Con A, Thrasher I, Tejani AM.
europepmc   +1 more source

Surgical Management of Bone Metastases in Bladder Cancer: A Single‐Center Retrospective Study

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Purpose Bladder cancer (BC) frequently spreads to the bone, resulting in skeletal‐related events with a major effect on quality of life. Since surgical treatment for bone metastases (BM) in BC patients remains understudied, we aimed to evaluate the outcome of surgery in a case series of 20 consecutive patients.
Pavlos Doumanidis, Panagiotis Tsagkozis
wiley   +1 more source

Tuberculous lymphadenitis presenting with hypercalcemia and acute kidney injury: Diagnostic challenges and management insights: A case report. [PDF]

Radiol Case Rep
Gupta S, Malde S, Kashiv P, Dubey S, Pawar T, Jeyachandran V, Kurundwadkar M, Sejpal K, Bawankule C, Pasari A, Balwani M.   +10 more
europepmc   +1 more source

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 696-702, March 2026.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

A New Model for Bone Health Management in Postmenopausal Early Breast Cancer Patients Undergoing Adjuvant Endocrine Therapy-The Predict & Prevent Project. [PDF]

Healthcare (Basel)
Gori S, Fabi A, Berardi R, Villa P, Zaniboni A, Prochilo T, Bighin C, Del Conte A, Riccardi F, Airoldi M, Chirco A, Cinieri S, Orlandi A, Assanti M, Valerio M, Tessari R, Mantoan C, Verzè M, Puglisi F, Nicolis F.   +19 more
europepmc   +1 more source

Fat Mass Influences Femur Bone Strength and Geometry Parameters, but Not Bone Mineral Density, in Autoimmune Diabetes: A Pilot Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Background Autoimmune diabetes (AD) increases fracture risk. Overweight worsens bone health despite increasing bone mineral density (BMD). This study examines how adiposity influences BMD and Dual X‐Ray Absorptiometry (DXA)‐derived parameters of bone geometry and strength in AD.
Renata Risi, Rocco Amendolara, Vahideh Abedi, Francesco De Vita, Federica Barbaro, Angela Balena, Mikiko Watanabe, Daniela Luverà, Angelo Lauria Pantano, Luca D'Onofrio, Raffaella Buzzetti, Ernesto Maddaloni, On behalf ofAD_OWOB study group   +12 more
wiley   +1 more source

Intravenous Pamidronate in Persistent Complex Regional Pain Syndrome (CRPS): A Retrospective Observational Study on Effectiveness and Tolerability. [PDF]

J Pain Res
van der Spek DPC, Huygen FJPM, Hoeks SE, van Daele PLA, Dirckx M.   +4 more
europepmc   +1 more source