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BK Polyomavirus-Associated Urothelial Carcinoma of the Bladder with a Background of BK Polyomavirus Nephropathy in a Kidney Transplant Recipient

Nephron, 2023
Renal transplant recipients are at increased risk for the development of a malignant neoplasm. Polyomavirus-associated urothelial carcinoma is a rare tumor that occurs in renal transplant recipients, with approximately 41 cases reported since 2002. It accounts for 27–31% of all post-transplant urothelial carcinomas and develops at an average of 8.5 ...
Sari Iwasaki   +9 more
openaire   +2 more sources

BK virus infection activates the TNFα/TNF receptor system in Polyomavirus-associated nephropathy

Molecular and Cellular Biochemistry, 2015
Polyomavirus-associated nephropathy due to BK virus infection (BKVAN) is recognized as an important cause of significant kidney transplant dysfunction often leading to renal graft loss. The activation of innate immune defense mechanisms during BKVAN is still poorly understood and an altered regulation of inflammatory mediators by resident kidney cells ...
Andrea, Ribeiro   +5 more
openaire   +2 more sources

Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy

Transplant Infectious Disease, 2016
AbstractA 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in ...
I O, Chikeka   +4 more
openaire   +2 more sources

Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients – A systematic review

Transplantation Reviews, 2020
BK polyomavirus (BKPyV) associated nephropathy (BKVAN) is seen in about 5% of renal transplant patients and can lead to chronic graft failure or graft loss. No effective therapy is available. Leflunomide has shown promising results in BKVAN. We performed a systematic review about the use of leflunomide for the treatment of BKVAN. The recommendations of
Laila, Schneidewind   +4 more
openaire   +2 more sources

Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study

Transplant Infectious Disease, 2019
AbstractBackgroundBK polyomavirus associated nephropathy (BKPyVAN) is a significant clinical issue in kidney transplant (KT) recipients. No specific therapy is currently available, although treatment with leflunomide may be part of the therapeutic strategy. Here, we sought to examine the impact of leflunomide on the evolution of BKPyVAN.MethodsThis was
Nicolas Keller   +8 more
openaire   +2 more sources

Evaluation of a Preemptive Strategy for BK Polyomavirus-Associated Nephropathy Based on Prospective Monitoring of BK Viremia: A Kidney Transplantation Center Experience

Transplantation Proceedings, 2010
BK polyomavirus-associated nephropathy (BKPVAN) is a major cause of renal failure early after kidney transplantation. The present study reports the preliminary results of prospective monitoring including a preemptive strategy for BKPVAN during the first year after kidney transplantation.We monitored BK virus DNA in blood at months 1, 2, 3, 6, 9, and 12
E, Renoult   +11 more
openaire   +2 more sources

#1951 Prediction of BK Polyomavirus associated nephropathy by the NEPHROVIR method in kidney transplant recipients with BK Polyomavirus-DNAemia

Nephrology Dialysis Transplantation
Abstract Background and Aims BK Polyomavirus (BKPyV) remains a significant complication after kidney transplantation. Due to BKPyV intra-graft replication, biopsy-proven BKPyV-associated nephropathy (BKPyVAN) affects nearly 10% of patients and causes graft loss in more than 50% of cases ...
Manon Dekeyser   +6 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce   +2 more
exaly  

Prognostic Biomarkers and Potential Treatment for BK Polyomavirus Associated Nephropathy

Transplantation, 2018
Minal Borkar-Tripathi   +4 more
openaire   +1 more source

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