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BK polyomavirus: emerging pathogen [PDF]

Microbes and Infection, 2012
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus.
Michael J Imperiale
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Antivirals for the treatment of polyomavirus BK replication

Expert Review of Anti-Infective Therapy, 2007
Antiviral drugs with specific activity against polyomavirus replication have not been developed in the past. This deficiency has become fully apparent with the emergence of polyomavirus-associated nephropathy in kidney-transplant recipients, with a prevalence rate of up to 10%. In most cases, high BK virus replication in tubular epithelial cells causes
Christine Hanssen Rinaldo, Hans H Hirsch
exaly   +3 more sources

Polyomavirus BK

The Lancet Infectious Diseases, 2003
Polyomavirus hominis 1, better known as BK virus (BKV), infects up to 90% of the general population. However, significant clinical manifestations are rare and limited to individuals with impaired immune functions. BKV has been associated with diverse entities such as haemorrhagic cystitis, ureteric stenosis, vasculopathy, pneumonitis, encephalitis ...
Hirsch HH, Steiger J
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Polyomavirus BK infection

Transplantation Proceedings, 2003
Because it is an important factor affecting renal transplant function, BK infections are significant problem in posttransplant. BK nephropathy develops in 5% of renal allograft recipients, in most cases within the first year after the procedure. The gold standard for BK nephropathy diagnosis is still immunohistochemical staining for large T antigen in ...
B, Matłosz, A, Mróz, M, Durlik, A, Wesołowska, A, Sadowska, T, Cieciura, A, Perkowska, D, Deborska-Materkowska, J, Szmidt, G, Michalak, L, Paczek, M, Lao   +11 more
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BK Polyomavirus-Associated Urothelial Carcinoma of the Bladder with a Background of BK Polyomavirus Nephropathy in a Kidney Transplant Recipient

Nephron, 2023
Renal transplant recipients are at increased risk for the development of a malignant neoplasm. Polyomavirus-associated urothelial carcinoma is a rare tumor that occurs in renal transplant recipients, with approximately 41 cases reported since 2002. It accounts for 27–31% of all post-transplant urothelial carcinomas and develops at an average of 8.5 ...
Sari Iwasaki, Kenta Takahashi, Harutaka Katano, Tadaki Suzuki, Hajime Sasaki, Hiroshi Harada, Yusuke Takada, Keishi Makita, Yuichiro Fukasawa, Takahiro Tsuji   +9 more
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Leflunomide for Polyomavirus Type BK Nephropathy

New England Journal of Medicine, 2005
To the Editor: Polyomavirus type BK nephropathy is an aggressively destructive disease occurring in up to 8 percent of patients with renal allografts,1,2 with rates of graft loss within one year of 30 to 65 percent.3,4 There is no therapy with proven efficacy.
James W, Williams, Basit, Javaid, Predeep V, Kadambi, Daniel, Gillen, Robert, Harland, J Richard, Thistlewaite, Marc, Garfinkel, Preston, Foster, Walter, Atwood, J Michael, Millis, Shane M, Meehan, Michelle A, Josephson   +11 more
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Transplacental transmission of human polyomavirus BK

Journal of Medical Virology, 1998
The presence of BK virus (BKV) and JC virus (JCV) in autopsy materials (placenta, brain, and kidney) of aborted fetuses was investigated by PCR using two sets of primers, specific for the regulatory region (RR) and for the capsid protein VP1, respectively.
PIETROPAOLO, Valeria Antonietta, DI TARANTO C., DEGENER, Anna Marta, JIN L., SINIBALDI, Laura, BAIOCCHINI A., MELIS, Marco, ORSI, Nicola   +7 more
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BK polyomavirus

Journal of Kidney Care
This article outlines what a patient needs to know about the BK polyomavirus and how it can effect a kidney transplant
Simon Baker, Mohammed Al Talib, Matthew Welberry Smith   +2 more
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Update on human polyomavirus BK nephropathy

Diagnostic Cytopathology, 2009
AbstractPolyomavirus BK (BKV) has ebeen identified as the main cause of polyomavirus‐associated nephropathy, a major cause of renal allograft failure. Although BKV‐associated nephropathy develops in only 2% to 5% of renal transplant recipients, its prognosis when present is very poor, with irreversible graft failure developing in 45% of affected ...
David, Cimbaluk, Lisa, Pitelka, Larry, Kluskens, Paolo, Gattuso   +3 more
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