Results 61 to 70 of about 25,650 (245)

High-level viruria as a screening tool for BK virus nephropathy in renal transplant recipients

Kidney Research and Clinical Practice, 2016
Background: Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN ...
W. James Chon, Nidhi Aggarwal, Masha Kocherginsky, Brenna Kane, Jozefa Sutor, Michelle A. Josephson   +5 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

BK Virus Nephropathy and Kidney Transplantation [PDF]

Clinical Journal of the American Society of Nephrology, 2007
Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant recipients. It is the consequence of modern potent immunosuppression aimed at reducing acute rejection and improving allograft survival. Untreated BKV infections lead to kidney allograft dysfunction or loss. Decreased immunosuppression is the principle treatment but
Daniel L, Bohl, Daniel C, Brennan
openaire   +2 more sources

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Update on the Management of BK Virus Infection

Experimental and Clinical Transplantation, 2020
The BK polyomavirus was isolated in 1971; it has been a significant risk factor for both graft dysfunction and failure in renal transplant recipients. So far, no specific treatment option has been available for effective treatment or prophylaxis for BK virus infections.
Ahmed, Saleh, Mohamed Salah, El Din Khedr, Abeer, Ezzat, Anna, Takou, Ahmed, Halawa   +4 more
openaire   +2 more sources

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19‐09, CONPELAN Study

Head &Neck, EarlyView.
ABSTRACT Background The benefit of consolidation programmed cell death protein 1 (PD‐1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II–IVB NPC were randomized (2:1) to pembrolizumab 200 mg or placebo every 3 weeks for up to 17 cycles after chemoradiotherapy ...
Sang Hoon Chun, Seyoung Seo, Jang Ho Cho, Keon‐Uk Park, Sang‐Cheol Lee, Yong Won Choi, Tak Yun, Seong Hoon Shin, Sung‐Bae Kim, Seungeun Lee, Chang Ho Ahn, Bhumsuk Keam   +11 more
wiley   +1 more source

BK viruria and viremia in children with systemic lupus erythematosus

Pediatric Rheumatology Online Journal, 2017
Background BK virus (BKV) is a ubiquitous polyoma virus that lies dormant in the genitourinary tract once acquired in early childhood. In states of cellular immunodeficiency, the virus can reactivate to cause hemorrhagic cystitis and nephritis.
Nirupama Gupta, Cuong Q. Nguyen, Renee F. Modica, Melissa E. Elder, Eduardo H. Garin   +4 more
doaj   +1 more source

BK virus-associated nephropathy in a lung transplant patient: case report and literature review

BMC Infectious Diseases, 2020
Background BK virus-associated nephropathy (BKVAN) is a relatively common cause of renal dysfunction in the first six months after renal transplantation.
Thomas Crowhurst, James Nolan, Randall Faull, Mark Holmes, Chien-Li Holmes-Liew   +4 more
doaj   +1 more source

Is quinoa‐farming sustainable in marginal environments? Social, economical and environmental aspects

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Quinoa (Chenopodium quinoa Willd.) is an Andean grain crop introduced as a novel crop to many parts of the world in recent years. Recognized for nutritious seeds and high abiotic stress tolerance, it has been promoted as an element of climate‐resilient agriculture, particularly in marginal environments.
Anna Tabea Mengen, Damir Esenaliev, Jakhongir Babadjanov, Lukas John, Sandra M. Schmöckel, Botir Khaitov   +5 more
wiley   +1 more source

Patient‐Centred Care in Atopic Dermatitis: Digital Communication, Misinformation, and Global Perspectives From the Pacecad Sessions (Isad Rajka Symposium, Melbourne 2025)

JEADV Clinical Practice, EarlyView.
ABSTRACT The PaCeCAD (Patient Centricity Care in Atopic Dermatitis) Sessions were held on Friday, October 24th, 2025, in Melbourne, Australia, as a conference‐format meeting during the first morning of the 15th Georg Rajka International Symposium on Atopic Dermatitis organized by the International Society of Atopic Dermatitis (ISAD).
Jean‐François Stalder, John C. Su, Fanny Sentenac, Mikael Alsterholm, Alpana Mohta, Hanof Ahmed, Pranvera Sulejmani, Kelly Barta, Kristin Bellenson, Fahafahantsoa Rapelanoro Rabenja, Tina Mesarič, Melanie Funk, Masaki Futamura, Kam Lun Ellis Hon, Kin Fon Leong, Laurent Elgard, David Troya, Alain Taïeb   +17 more
wiley   +1 more source