Results 121 to 130 of about 13,979 (215)

膀胱癌新型标志物BLCA-4蛋白的研究进展

, 2007
膀胱癌是常见的恶性肿瘤之一,复发率高。传统的诊断方法多有创伤性,检删方法敏感性和特异性不高。随着分子生物学发展,近年来发现了6种新的膀胱癌特异性核基质蛋白,其中尿液BLCA-4蛋白对膀胱癌早期诊断具有较好的临床应用前景,现就BLCA-4蛋白研究现状进行综述。厦门市卫生局2004年度医学科研立项(厦卫科教中医2004-400号)
张忠英, 陈亮, 刘莉莉
core  

A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer

Frontiers in Oncology
PurposeBladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA.
Yiqiang Da, Zirong Lu, Zirong Lu, Zijian Zhu, Hongrui Tai, Yuan Liu, Yichao Zhu, Yichao Zhu   +7 more
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Urinary IL-8 and BLCA-4 in detection of bladder cancer and their clinical significant

Iraqi Journal of Cancer and Medical Genetics, 2018
Bladder cancer is a highly prevalent human disease world wide This study of bladder cancer was conducted to assess the significance of level difference in some cancer biomarkers in bladder cancer patients, like IL-8 which is an angiogenic factor associated with inflammation and carcinogenesis and Bladder cancer-associated protein (BLCA4) that is a ...
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Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway

International Journal of Biological Sciences
Ubiquitination, a prevalent and highly dynamic reversible post-translational modification, is tightly regulated by the deubiquitinating enzymes (DUBs) superfamily. Among them, OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1 (OTUB1) stands out as a critical member of the OTU deubiquitinating family, playing a pivotal role as a tumor regulator
Liao, Yihao, Liang, Jiaming, Wang, Youzhi, Li, An, Liu, Wenbo, Zhong, Boqiang, Wang, Keke, Zhou, Diansheng, Guo, Tao, Guo, Jianing, Yu, Xi, Jiang, Ning   +11 more
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Exploring the Transcriptomic Landscape of Blca: Shtn1 as a Key Player in Photodynamic Therapy Response

Abstract Background A high recurrence rate and a tendency to progress to more advanced, invasive stages characterize bladder urothelial carcinoma (BLCA), the ninth most common malignant tumor worldwide. Despite its potential, photodynamic therapy (PDT), a minimally invasive treatment, remains underutilized in BLCA management.
Zhengang Shen, Jiayi Lu, Haojin Cheng, Xiaodi Tang, Li Chen, Hong Liao, Shukui Zhou   +6 more
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BLCA-4 [PDF]

, 2020
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Transient Receptor Potential Melastatin 4 (TRPM4) is associated with an immuno-stimulatory TME and better prognosis in BLCA

Discover Oncology
Bladder cancer (BLCA) is one of the most invasive and malignant tumors in the world, thus leading to the urgent need of an accurate and recognizable biomarker. Several previous research has shown that Transient Receptor Potential Melastatin 4 (TRPM4) plays an important role in measuring vascular fragility and endothelial function.
Da, Yiqiang, Chen, Xuerui, Yu, Lanxin, Li, Yunxin, Chen, Zixu, Zhang, Yuyue, Wang, Hualin, Zhu, Zhuang, Liu, Yuan, Geng, Yao   +9 more
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Development of a prognostic model related to mitochondria and programmed cell death-related genes in bladder cancer

Frontiers in Genetics
BackgroundVarious forms of programmed cell death (PCD) play a crucial role in regulating the development and spread of cancer, with mitochondria serving as key organelles involved in executing PCD.
Xuwei Zhao, Xuwei Zhao, Hongyao Liu, Hongyao Liu, Chao Wang, Chao Wang, Fuyu Guo, Bin Yang, Bin Yang   +8 more
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MFSD12, transcriptionally regulated by PLAGL2, promotes bladder cancer progression

Communications Biology
Bladder cancer (BLCA) is one of the most common malignant tumors of the urinary system. Identification of novel molecular signaling targets for the tumorigenesis of BLCA is important.
Jiani He, Changming Dong, Xiandong Song, Xinyu Bao, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man   +8 more
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High expression level of BLCA-4 correlates with poor prognosis in human bladder cancer.

International journal of clinical and experimental pathology, 2012
To evaluate the association between BLCA-4 tissue expression and patients' prognosis in bladder cancer (BC).BLCA-4 expression was analyzed using immunohistochemical staining methods on tissue samples from a consecutive series of 325 BC patients who underwent resections between 2000 and 2006.
Qian, Zhao, Wen-Hao, Shen, Zhi-Wen, Chen, Zhan-Song, Zhou, Hui-Xiang, Ji   +4 more
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