Results 111 to 120 of about 13,979 (215)

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning

Scientific Reports
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME).
Yutong Li, Ling Zuo, Xingyu Song, Yuyang Huang, Ke Zou, Xuan Dong, Hongwei Liu   +6 more
doaj   +1 more source

Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway

Scientific Reports
Bladder cancer (BLCA) is one of the ten most common cancers worldwide. However, the deregulation of PROS1 and its specific function in BLCA is not well understood.
Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang   +8 more
doaj   +1 more source

A co-expression network for differentially expressed genes in bladder cancer and a risk score model for predicting survival [PDF]

, 2019
Background: Urothelial bladder cancer (BLCA) is one of the most common internal malignancies worldwide with poor prognosis. This study aims to explore effective prognostic biomarkers and construct a prognostic risk score model for patients with BLCA ...
Chen, Z., Tuzankina, I. A., Bolkov, M. A., Liu, G., Tan, W., Hossain, A., Danilova, I. G.   +6 more
core   +1 more source

Ferroptosis-related lncRNA AL136084.3 is associated with NUPR1 in bladder cancer

Discover Oncology
Background LncRNAs are critical regulators of bladder cancer (BLCA), and ferroptosis is a newly discovered cell death responsible for mediating apoptosis and tumorigenesis.
Jing Zhou, Li Zhang, Hao Wu, Sheng-Lin Gao, Xiao-Ping Chen, Li-Feng Zhang, Cui-Ping Zhao, Bing-Bing Wei, Yu Bai   +8 more
doaj   +1 more source

Multiscale screening and identifying specific targets for artesunate in suppressing bladder cancer

Frontiers in Pharmacology
BackgroundBladder cancer (BLCA) is a highly aggressive urinary malignancy with high mortality in advanced stages, posing a significant health risk. Artesunate (ART), a derivative of artemisinin, has been demonstrated with potent anti-tumor activity in ...
Yi Yuan, Guangdi Chu, Qingyue Ma, Zhijuan Liang, Ye Liang, Haitao Niu, Haitao Niu   +6 more
doaj   +1 more source

SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer

Cell & Bioscience
Background Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progression and metastasis.
Xiaojing Wang, Peipei Zhang, Jiaqi Yan, Jingyi Huang, Yan Shen, Hongchao He, Hongjing Dou   +6 more
doaj   +1 more source

Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis

Frontiers in Immunology
BackgroundBladder cancer (BLCA) continues to be a significant cause of cancer mortality in the urinary tract, with therapeutic resistance representing a major barrier to improving patient outcomes.
Zhaokai Zhou, Yajun Chen, Zhan Wang, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li, Ran Xu   +10 more
doaj   +1 more source

Macrophage Cell and Diagnostic Biomarkers in BLCA: Integrating Machine Learning With Single-Cell Analysis

Clinical Genitourinary Cancer
Bladder cancer (BLCA) has a poor prognosis and continues to pose a significant challenge for clinicians. Prior studies have demonstrated a close relationship of BLCA with macrophages. However, the key subpopulations and molecular functions of macrophages in BLCA have not been uncovered.
Guangliang, Che, Xuejun, Zhao, Rongtuan, Luo, Quanfeng, Yu, Xiaofeng, Guo, Ke, Gao, Kangyu, Chen, Erfeng, Zhang   +7 more
openaire   +2 more sources

Exploration of neutrophil-associated genes in the prognosis of bladder urothelial carcinoma based on a machine learning and multi-omics data integration framework

Human Genomics
Background Bladder urothelial carcinoma (BLCA) is a prevalent malignancy. The poor performance of existing therapeutic approaches in the advanced stages of BLCA underscores the critical need for more sensitive and precise biomarkers to improve patient ...
Muya Ran, Xiaoming Chen, Guancheng Xiao, RuoHui Huang, Wei Xia, QingMing Zeng, Gang Xu, Bo Jiang   +7 more
doaj   +1 more source

TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis

Cell Death Discovery
Bladder cancer (BLCA) is a prevalent malignancy characterized by high recurrence and metastasis rates. Emerging evidence suggests that the NRF2-GPX4 axis is closely associated with ferroptosis. The transcriptional coactivator with PDZ-binding motif (TAZ)
Zhen Song, Shikai Gui, Xuepeng Rao, Gan Zhang, Yu Cheng, Tao Zeng   +5 more
doaj   +1 more source