Results 111 to 120 of about 12,929 (204)

Multiscale screening and identifying specific targets for artesunate in suppressing bladder cancer

Frontiers in Pharmacology
BackgroundBladder cancer (BLCA) is a highly aggressive urinary malignancy with high mortality in advanced stages, posing a significant health risk. Artesunate (ART), a derivative of artemisinin, has been demonstrated with potent anti-tumor activity in ...
Yi Yuan, Guangdi Chu, Qingyue Ma, Zhijuan Liang, Ye Liang, Haitao Niu, Haitao Niu   +6 more
doaj   +1 more source

Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis

Frontiers in Immunology
BackgroundBladder cancer (BLCA) continues to be a significant cause of cancer mortality in the urinary tract, with therapeutic resistance representing a major barrier to improving patient outcomes.
Zhaokai Zhou, Yajun Chen, Zhan Wang, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li, Ran Xu   +10 more
doaj   +1 more source

Urinary IL-8 and BLCA-4 in detection of bladder cancer and their clinical significant

Iraqi Journal of Cancer and Medical Genetics, 2018
Bladder cancer is a highly prevalent human disease world wide This study of bladder cancer was conducted to assess the significance of level difference in some cancer biomarkers in bladder cancer patients, like IL-8 which is an angiogenic factor associated with inflammation and carcinogenesis and Bladder cancer-associated protein (BLCA4) that is a ...
openaire   +1 more source

A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer

Frontiers in Oncology
PurposeBladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA.
Yiqiang Da, Zirong Lu, Zirong Lu, Zijian Zhu, Hongrui Tai, Yuan Liu, Yichao Zhu, Yichao Zhu   +7 more
doaj   +1 more source

Exploring the transcriptomic landscape of BLCA: SHTN1 as a key player in photodynamic therapy response

Abstract Background A high recurrence rate and a tendency to progress to more advanced, invasive stages characterize bladder urothelial carcinoma (BLCA), the ninth most common malignant tumor worldwide. Despite its potential, photodynamic therapy (PDT), a minimally invasive treatment, remains underutilized in BLCA management.
Zhengang Shen, Jiayi Lu, Haojin Cheng, Xiaodi Tang, Yunlong Li, Li Chen, Junfeng Liu, Guangqiang Hu, Yong Yu, Xingyue Han, Hong Liao, Shukui Zhou   +11 more
openaire   +2 more sources

Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway

International Journal of Biological Sciences
Ubiquitination, a prevalent and highly dynamic reversible post-translational modification, is tightly regulated by the deubiquitinating enzymes (DUBs) superfamily. Among them, OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1 (OTUB1) stands out as a critical member of the OTU deubiquitinating family, playing a pivotal role as a tumor regulator
Liao, Yihao, Liang, Jiaming, Wang, Youzhi, Li, An, Liu, Wenbo, Zhong, Boqiang, Wang, Keke, Zhou, Diansheng, Guo, Tao, Guo, Jianing, Yu, Xi, Jiang, Ning   +11 more
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NOTCH3 promotes malignant progression of bladder cancer by directly regulating SPP1 and activating PI3K/AKT pathway [PDF]

The biological role and precise molecular mechanisms of Notch receptor 3 (NOTCH3) in the malignant progression of bladder cancer (BLCA) remain unclear. In this study, we found that NOTCH3 was significantly upregulated and associated with poor prognosis ...
Xinzhao Zhao, Huaixi Ge, Changxue Liu, Ruize Qin, Yonghua Wang, Chengquan Shen, Ding Hu   +6 more
core   +1 more source

BLCA-4 [PDF]

, 2020
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Development of a prognostic model related to mitochondria and programmed cell death-related genes in bladder cancer

Frontiers in Genetics
BackgroundVarious forms of programmed cell death (PCD) play a crucial role in regulating the development and spread of cancer, with mitochondria serving as key organelles involved in executing PCD.
Xuwei Zhao, Xuwei Zhao, Hongyao Liu, Hongyao Liu, Chao Wang, Chao Wang, Fuyu Guo, Bin Yang, Bin Yang   +8 more
doaj   +1 more source

MFSD12, transcriptionally regulated by PLAGL2, promotes bladder cancer progression

Communications Biology
Bladder cancer (BLCA) is one of the most common malignant tumors of the urinary system. Identification of novel molecular signaling targets for the tumorigenesis of BLCA is important.
Jiani He, Changming Dong, Xiandong Song, Xinyu Bao, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man   +8 more
doaj   +1 more source