Results 111 to 120 of about 15,721 (211)

Identification of FLRT2 as a key prognostic gene through a comprehensive analysis of TMB and IRGPs in BLCA patients

Frontiers in Oncology
IntroductionThe tumor immune environment and immune-related genes are instrumental in the development, progression, and prognosis of bladder cancer (BLCA). This study sought to pinpoint key immune-related genes influencing BLCA prognosis and decipher their mechanisms of action.Methods and resultsWe analyzed differentially expressed genes (DEGs) between
Yaling Tao, Yaling Tao, Xiaoling Yu, Huaiwei Cong, Jinpeng Li, Jinpeng Li, Junqi Zhu, Huaxin Ding, Qian Chen, Qian Chen, Qian Chen, Ting Cai, Ting Cai   +12 more
openaire   +3 more sources

TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis

Cell Death Discovery
Bladder cancer (BLCA) is a prevalent malignancy characterized by high recurrence and metastasis rates. Emerging evidence suggests that the NRF2-GPX4 axis is closely associated with ferroptosis. The transcriptional coactivator with PDZ-binding motif (TAZ)
Zhen Song, Shikai Gui, Xuepeng Rao, Gan Zhang, Yu Cheng, Tao Zeng   +5 more
doaj   +1 more source

Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis

Frontiers in Immunology
BackgroundBladder cancer (BLCA) continues to be a significant cause of cancer mortality in the urinary tract, with therapeutic resistance representing a major barrier to improving patient outcomes.
Zhaokai Zhou, Yajun Chen, Zhan Wang, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li, Ran Xu   +10 more
doaj   +1 more source

Young AIDS Migrants in Southern Africa [PDF]

, 2002
Many young people in southern Africa engage in AIDS-related migration. Research conducted with urban and rural-based children in Malawi and Lesotho revealed that children are commonly sent to live with relatives resident elsewhere. They move in order to
Ansell, N, Young, L
core  

A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer

Frontiers in Oncology
PurposeBladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA.
Yiqiang Da, Zirong Lu, Zirong Lu, Zijian Zhu, Hongrui Tai, Yuan Liu, Yichao Zhu, Yichao Zhu   +7 more
doaj   +1 more source

Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway

International Journal of Biological Sciences
Ubiquitination, a prevalent and highly dynamic reversible post-translational modification, is tightly regulated by the deubiquitinating enzymes (DUBs) superfamily. Among them, OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1 (OTUB1) stands out as a critical member of the OTU deubiquitinating family, playing a pivotal role as a tumor regulator
Liao, Yihao, Liang, Jiaming, Wang, Youzhi, Li, An, Liu, Wenbo, Zhong, Boqiang, Wang, Keke, Zhou, Diansheng, Guo, Tao, Guo, Jianing, Yu, Xi, Jiang, Ning   +11 more
openaire   +2 more sources

Urinary IL-8 and BLCA-4 in detection of bladder cancer and their clinical significant

Iraqi Journal of Cancer and Medical Genetics, 2018
Bladder cancer is a highly prevalent human disease world wide This study of bladder cancer was conducted to assess the significance of level difference in some cancer biomarkers in bladder cancer patients, like IL-8 which is an angiogenic factor associated with inflammation and carcinogenesis and Bladder cancer-associated protein (BLCA4) that is a ...
openaire   +1 more source

BLCA-RegMap portal: a co-regulatory influence network view of bladder cancer heterogeneity

, 2022
Introduction: Bladder cancer studies performed in a variety of laboratories and by anumber of large-scale projects have given an unparalleled amount of information on tumors and in vitro models. Consolidating these data into an easily accessible and comprehensive system-level format is crucial to accelerate systems oncology model development.Methods ...
Pawlak, Geoffrey, Puig, Julia, Dispot, Aurélien, Dhifli, Wajdi, Elati, Mohamed   +4 more
openaire   +1 more source

Exploring the transcriptomic landscape of BLCA: SHTN1 as a key player in photodynamic therapy response

Abstract Background A high recurrence rate and a tendency to progress to more advanced, invasive stages characterize bladder urothelial carcinoma (BLCA), the ninth most common malignant tumor worldwide. Despite its potential, photodynamic therapy (PDT), a minimally invasive treatment, remains underutilized in BLCA management.
Zhengang Shen, Jiayi Lu, Haojin Cheng, Xiaodi Tang, Yunlong Li, Li Chen, Junfeng Liu, Guangqiang Hu, Yong Yu, Xingyue Han, Hong Liao, Shukui Zhou   +11 more
openaire   +2 more sources

BLCA-4 [PDF]

, 2020
openaire   +1 more source