Results 101 to 110 of about 12,929 (204)

TONSL Promotes Hepatocellular Carcinoma Progression by Inhibiting Apoptosis Through Homologous Recombination Repair

Cancer Science, Volume 117, Issue 7, Page 1852-1866, July 2026.
In hepatocellular carcinoma, the 8q24.3 locus is frequently amplified and is associated with tumor‐specific overexpression of TONSL. TONSL promotes homologous recombination repair through RAD51, limits γH2AX accumulation and apoptosis, supports tumor growth, and its loss increases sensitivity to poly (ADP‐ribose) polymerase (PARP) inhibition.
Akinori Tsujimoto, Hajime Otsu, Takashi Ofuchi, Tomohiko Ikehara, Kosuke Hirose, Shohei Shibuta, Kazuki Omachi, Yu Takahashi, Yuya Ono, Satoshi Higuchi, Takanari Tatsumi, Kiyotaka Hosoda, Qingjiang Hu, Yusuke Yonemura, Takaaki Masuda, Masayuki Sho, Koshi Mimori   +16 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, Volume 16, Issue 6, Page 1197-1212, June 2026.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

circPVT1 Inhibits the Proliferation and Aids in Prediction of the Prognosis of Bladder Cancer

Pharmacogenomics and Personalized Medicine
Hongyi Zhou,1,* Xueping Cui,2,* Leilei Zhu,1 Zhuoqun Xu,1 Zhuo Wang,3 Jianfeng Shao4 1Department of Urology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214023, People’s Republic of China ...
Zhou H, Cui X, Zhu L, Xu Z, Wang Z, Shao J   +5 more
doaj  

Macrophage Cell and Diagnostic Biomarkers in BLCA: Integrating Machine Learning With Single-Cell Analysis

Clinical Genitourinary Cancer
Bladder cancer (BLCA) has a poor prognosis and continues to pose a significant challenge for clinicians. Prior studies have demonstrated a close relationship of BLCA with macrophages. However, the key subpopulations and molecular functions of macrophages in BLCA have not been uncovered.
Guangliang, Che, Xuejun, Zhao, Rongtuan, Luo, Quanfeng, Yu, Xiaofeng, Guo, Ke, Gao, Kangyu, Chen, Erfeng, Zhang   +7 more
openaire   +2 more sources

CDCA3-MYC positive feedback loop promotes bladder cancer progression via ENO1-mediated glycolysis

Journal of Experimental & Clinical Cancer Research
Background Bladder cancer (BLCA) ranks among the most prevalent malignancies of the urinary system, with its clinical diagnosis predominantly reliant on invasive procedures.
Dexin Shen, Xiang Yu, Xuefeng Fan, Yu Liang, Dongmei Lu, Zongpan Ke, Lei Wang, Ping Xiang, Jun Xiao   +8 more
doaj   +1 more source

The Cancer Genome Atlas Urothelial Bladder Carcinoma Collection (TCGA-BLCA)

, 2016
D., M., ., . ., ., ., . (2016): The Cancer Genome Atlas Urothelial Bladder Carcinoma Collection (TCGA-BLCA). Ecologica Montenegrina 6: 34-36, DOI: 10.7937/k9/tcia.2016.8lng8xdr, URL: http://dx.doi.org/10.7937/k9/tcia.2016 ...
D., M.
openaire   +1 more source

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning

Scientific Reports
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME).
Yutong Li, Ling Zuo, Xingyu Song, Yuyang Huang, Ke Zou, Xuan Dong, Hongwei Liu   +6 more
doaj   +1 more source

Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway

Scientific Reports
Bladder cancer (BLCA) is one of the ten most common cancers worldwide. However, the deregulation of PROS1 and its specific function in BLCA is not well understood.
Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang   +8 more
doaj   +1 more source

Ferroptosis-related lncRNA AL136084.3 is associated with NUPR1 in bladder cancer

Discover Oncology
Background LncRNAs are critical regulators of bladder cancer (BLCA), and ferroptosis is a newly discovered cell death responsible for mediating apoptosis and tumorigenesis.
Jing Zhou, Li Zhang, Hao Wu, Sheng-Lin Gao, Xiao-Ping Chen, Li-Feng Zhang, Cui-Ping Zhao, Bing-Bing Wei, Yu Bai   +8 more
doaj   +1 more source

SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer

Cell & Bioscience
Background Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progression and metastasis.
Xiaojing Wang, Peipei Zhang, Jiaqi Yan, Jingyi Huang, Yan Shen, Hongchao He, Hongjing Dou   +6 more
doaj   +1 more source