Results 91 to 100 of about 15,721 (211)

The role of a new class of long noncoding RNAs transcribed from ultraconserved regions in cancer [PDF]

, 2017
Ultraconserved regions (UCRs) represent a relatively new class of non-coding genomic sequences highly conserved between human, rat and mouse genomes.
Calin, George A., Cimmino, Amelia, Costa, Valerio, de Nigris, Filomena, Terracciano, Daniela, Terreri, Sara   +5 more
core   +1 more source

Decoding the Oncogenic Role of USP22 Through Pan‐Cancer Genomic and Epigenetic Analysis

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Ubiquitin‐specific protease 22, an important catalytic component of the human SAGA (Spt‐Ada‐GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences gene expression. Its overexpression alters gene regulation, transcription, cancer progression, and therapy resistance.
Uma Devi A., Prakash Kumar Shukla
wiley   +1 more source

Divergent viral presentation among human tumors and adjacent normal tissues [PDF]

, 2016
We applied a newly developed bioinformatics system called VirusScan to investigate the viral basis of 6,813 human tumors and 559 adjacent normal samples across 23 cancer types and identified 505 virus positive samples with distinctive, organ system- and ...
Cao, Song, Chen, Feng, Chen, Ken, Ding, Li, Dipersio, John F, Gay, Hiram, Grubb III, Robert, Jayasinghe, Reyka, Johnson, Kimberly J, Niu, Beifang, Rader, Janet S, Wendl, Michael C, Wu, Song, Wyczalkowski, Matthew A, Wylie, Kristine, Xie, Mingchao, Ye, Kai   +16 more
core   +2 more sources

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

CALR/HIF‐1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT‐Mediated Bladder Cancer Progression via ROS/AKT Axis

Cancer Science, Volume 117, Issue 5, Page 1286-1302, May 2026.
This study first found that the high expression of CALR is due to a novel positive feedback loop with HIF‐1α in the tumor microenvironment: CALR stabilizes HIF‐1α protein, while HIF‐1α transcriptionally upregulates CALR expression, thereby self‐sustaining its high expression levels in BLCA.
Xintao Tian, Yue Liu, Zhiyuan Mi, Ye Liang, Zhao Zhang, Xiaocheng Ma, Huiqing Jia, Yuxuan Cao, Zhijuan Liang, Shaonan Yang, Guofeng Ma, Haitao Niu   +11 more
wiley   +1 more source

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif [PDF]

, 2013
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types.
Coarfa, Cristian, Ding, Li, Gunaratne, Preethi H., Hamilton, Mark P., Hartig, Sean M., Kandoth, Cyriac, McGuire, Sean E., McLellan, Michael D., Rajapakshe, Kimal, Reva, Boris, Wheeler, David A., Zack, Travis I.   +11 more
core   +3 more sources

Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT

Advanced Science
Bladder cancer (BLCA) is a prevalent cancer with high case‐fatality rates and a substantial economic burden worldwide. Understanding its molecular underpinnings to guide clinical management is crucial. Ferroptosis, a recently described non‐apoptotic form
Jianmin Liu, Yongwen Luo, Siming Chen, Gang Wang, Wan Jin, Wenyu Jiang, Mingxing Li, Yejinpeng Wang, Jingtian Yu, Houyi Wei, Renjie Zhang, Fenfang Zhou, Lingao Ju, Yi Zhang, Yu Xiao, Kaiyu Qian, Xinghuan Wang   +16 more
doaj   +1 more source

Refining a molecular tool kit to capture tropicalization in Mediterranean marine protected areas

Conservation Science and Practice, Volume 8, Issue 5, May 2026.
We assess complementarity and trade‐offs between visual census and eDNA metabarcoding for monitoring fish community changes in MPAs. Abstract Tropicalization, the process by which tropical species expand their ranges poleward due to global ocean warming, is a prominent threat to Mediterranean marine ecosystems, challenging their effective management ...
Erika Frances Neave, Charalampos Dimitriadis, Peter Shum, Ana Riesgo, Stefano Mariani   +4 more
wiley   +1 more source

Macrophage Cell and Diagnostic Biomarkers in BLCA: Integrating Machine Learning With Single-Cell Analysis

Clinical Genitourinary Cancer
Bladder cancer (BLCA) has a poor prognosis and continues to pose a significant challenge for clinicians. Prior studies have demonstrated a close relationship of BLCA with macrophages. However, the key subpopulations and molecular functions of macrophages in BLCA have not been uncovered.
Guangliang, Che, Xuejun, Zhao, Rongtuan, Luo, Quanfeng, Yu, Xiaofeng, Guo, Ke, Gao, Kangyu, Chen, Erfeng, Zhang   +7 more
openaire   +2 more sources