Results 81 to 90 of about 67,281 (289)

Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release

Nanomaterials
Developing prolonged antigen delivery systems that mimic long-term exposure to pathogens appears as a promising but still poorly explored approach to reach durable immunities.
Laia Bosch-Camós, Carlos Martínez-Torró, Hèctor López-Laguna, Jara Lascorz, Jordi Argilaguet, Antonio Villaverde, Fernando Rodríguez, Esther Vázquez   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Building blocks for a digital twin of large cool store complexes

, 2023
Digital twins are virtual representations that serve as real-time digital counterparts of physical objects spanning their full lifecycle. In the context of postharvest horticulture, these represent infrastructure (storage plants including refrigeration and controlled atmosphere systems) and the produce being handled (fruit and vegetables).
Phan, Hoang Minh, Van Cauteren, Hans, Hertog, Maarten, Verlinden, Bert, Nicolai, Bart, Verboven, Pieter   +5 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CD-STMamba: Toward Remote Sensing Image Change Detection With Spatio-Temporal Interaction Mamba Model

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Change detection (CD) is a critical Earth observation task. Convolutional neural network (CNN) and Transformer have demonstrated their superior performance in CD tasks.
Shanwei Liu, Shuaipeng Wang, Wei Zhang, Tao Zhang, Mingming Xu, Muhammad Yasir, Shiqing Wei   +6 more
doaj   +1 more source

Beyond Fundamental Building Blocks: Plasticity in Structurally Complex Crystals

Advanced Materials
AbstractIntermetallics, which encompass a wide range of compounds, often exhibit similar or closely related crystal structures, resulting in various intermetallic systems with structurally derivative phases. This study examines the hypothesis that deformation behavior can be transferred from fundamental building blocks to structurally related phases ...
Stollenwerk, Tobias, Huckfeldt, Pia Carlotta, Ulumuddin, Nisa Zakia Zahra, Schneider, Malik, Xie, Zhuocheng, Korte‐Kerzel, Sandra   +5 more
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Computational Model of Symbiotic Composition in Evolutionary Transitions [PDF]

, 2002
Several of the major transitions in evolutionary history, such as the symbiogenic origin of eukaryotes from prokaryotes, share the feature that existing entities became the components of composite entities at a higher level of organisation.
Jordan B. Pollack, Pollack, Jordan B., Richard A. Watson, Watson, Richard A.   +3 more
core   +1 more source

Extracting Buildings from True Color Stereo Aerial Images Using a Decision Making Strategy

Remote Sensing, 2011
The automatic extraction of buildings from true color stereo aerial imagery in a dense built-up area is the main focus of this paper. Our approach strategy aimed at reducing the complexity of the image content by means of a three-step procedure combining
Eufemia Tarantino, Benedetto Figorito
doaj   +1 more source