Results 81 to 90 of about 6,165,336 (284)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Robo-Matter towards reconfigurable multifunctional smart materials

Nature Communications
Maximizing materials utilization efficiency via enhancing their reconfigurability and multifunctionality offers a promising avenue in addressing the global challenges in sustainability.
Jing Wang, Gao Wang, Huaicheng Chen, Yanping Liu, Peilong Wang, Daming Yuan, Xingyu Ma, Xiangyu Xu, Zhengdong Cheng, Baohua Ji, Mingcheng Yang, Jianwei Shuai, Fangfu Ye, Jin Wang, Yang Jiao, Liyu Liu   +15 more
doaj   +1 more source

Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release

Nanomaterials
Developing prolonged antigen delivery systems that mimic long-term exposure to pathogens appears as a promising but still poorly explored approach to reach durable immunities.
Laia Bosch-Camós, Carlos Martínez-Torró, Hèctor López-Laguna, Jara Lascorz, Jordi Argilaguet, Antonio Villaverde, Fernando Rodríguez, Esther Vázquez   +7 more
doaj   +1 more source

Building blocks for a digital twin of large cool store complexes

, 2023
Digital twins are virtual representations that serve as real-time digital counterparts of physical objects spanning their full lifecycle. In the context of postharvest horticulture, these represent infrastructure (storage plants including refrigeration and controlled atmosphere systems) and the produce being handled (fruit and vegetables).
Phan, Hoang Minh, Van Cauteren, Hans, Hertog, Maarten, Verlinden, Bert, Nicolai, Bart, Verboven, Pieter   +5 more
openaire   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Beyond Fundamental Building Blocks: Plasticity in Structurally Complex Crystals

Advanced Materials
AbstractIntermetallics, which encompass a wide range of compounds, often exhibit similar or closely related crystal structures, resulting in various intermetallic systems with structurally derivative phases. This study examines the hypothesis that deformation behavior can be transferred from fundamental building blocks to structurally related phases ...
Stollenwerk, Tobias, Huckfeldt, Pia Carlotta, Ulumuddin, Nisa Zakia Zahra, Schneider, Malik, Xie, Zhuocheng, Korte‐Kerzel, Sandra   +5 more
openaire   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CD-STMamba: Toward Remote Sensing Image Change Detection With Spatio-Temporal Interaction Mamba Model

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Change detection (CD) is a critical Earth observation task. Convolutional neural network (CNN) and Transformer have demonstrated their superior performance in CD tasks.
Shanwei Liu, Shuaipeng Wang, Wei Zhang, Tao Zhang, Mingming Xu, Muhammad Yasir, Shiqing Wei   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source