Results 71 to 80 of about 724,525 (268)
Increasing efficiency of preclinical research by group sequential designs.
PLoS Biology, 2017 Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs.
Konrad Neumann +11 more
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Comparison Between some Methods of Tackling the Lack of Experimental Units Needed for Application of Factorial Experiments [PDF]
المجلة العراقية للعلوم الاحصائية, 2011 Most of the time the researcher confronts a decrease in the experimental units required when applying a certain design, this problem appears especially when conducting the factorial experiments which mostly need great numbers of experimental units, to ...
doaj +1 more source
, 2008 One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L.
A. Betten +40 more
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Optimal two-level conjoint designs for large numbers of attributes. [PDF]
In this paper, we propose a simple strategy to construct D-, A-, G- and V-optimal two-level multi-attribute designs for rating-based conjoint studies. Our approach combines orthogonal designs and balanced or partially balanced incomplete block designs ...
Goos, P +2 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
New Constructions and Necessary Conditions for 4-GDDs With Block Size 5
International Journal of Mathematics and Mathematical Sciencest-v,k,Λ designs are well-known objects of study. Here, we define t-group divisible designs (t-GDDs) and specifically study t-GDDs, where the number of groups are less than the block size. After a short survey of t-GDDs, we will present some examples of 4-
Dinkayehu M. Woldemariam, D. G. Sarvate
doaj +1 more source
Missing Data Imputation in Balanced Construction for Incomplete Block Designs
MathematicsObservational data with massive sample sizes are often distributed on many local machines. From an experimental design perspective, investigators often desire to identify the effect of new treatments (even ML algorithms) on many blocks of experimental ...
Haiyan Yu +3 more
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Block designs with repeated blocks
Discrete Mathematics, 1972 AbstractThis paper investigates the structure of block designs with repeated blocks. Let the block design on the parameters b, v, r, k, and λ contain exactly t distinct blocks B1, B2, …, Bt. Let block Bi be repeated exactly ei times and define E =daig [e1,…et].
van Lint, J.H., Ryser, H.J.
openaire +2 more sources