Results 41 to 50 of about 715,847 (243)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Monitoring regional blockade [PDF]
Anaesthesia, 2017 SummaryThis review attempts to draw on the published literature to address three practical clinical questions. First, what means of testing the degree of regional blockade pre‐operatively are available, and can eventual success or failure be determined soon after injection?
Andrew F Smith, S. Selvaraj, K. Ode
openaire +3 more sources
Thermal broadening of the Coulomb blockade peaks in quantum Hall interferometers
, 2010 We demonstrate that the differential magnetic susceptibility of a fractional quantum Hall disk, representing a Coulomb island in a Fabry--Perot interferometer, is exactly proportional to the island's conductance and its paramagnetic peaks are the ...
Cappelli A. +7 more
core +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
The Game of “Naval Blockade.” [PDF]
Royal United Services Institution. Journal, 1888 n ...
openaire +3 more sources
Tunable phonon blockade in weakly nonlinear coupled mechanical resonators via Coulomb interaction
, 2018 Realizing quantum mechanical behavior in micro- and nanomechanical resonators has attracted continuous research effort. One of the ways for observing quantum nature of mechanical objects is via the mechanism of phonon blockade.
Sarma, Amarendra K., Sarma, Bijita
core +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Coulomb blockade in superconducting quantum point contacts
, 1998 Amplitude of the Coulomb blockade oscillations is calculated for a single-mode Josephson junction with arbitrary electron transparency $D$. It is shown that the Coulomb blockade is suppressed in ballistic junctions with $D\to 1$.
A. Furusaki +21 more
core +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source