Results 81 to 90 of about 1,026,952 (386)

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation

Frontiers in Immunology
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS ...
Liqiong Jiang, Lars P. Lunding, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Ulrich Pessara, Daniel Parera, Daniel Parera, David J. Orlicky, Stephan Fischer, Stephan Fischer, Michael Wegmann, Michael Wegmann, Charles A. Dinarello, Suzhao Li   +21 more
doaj   +1 more source

Coulomb blockade without potential barriers

, 2006
We study transport through a strongly correlated quantum dot and show that Coulomb blockade can appear even in the presence of perfect contacts. This conclusion arises from numerical calculations of the conductance for a microscopic model of spinless ...
Aleiner, Alphenaar, Beenakker, Berkovits, Blanter, Boehm, Bohr, Brouwer, Cohen, D. Weinmann, Favand, Friedel, G. Vasseur, Golubev, Huibers, Langer, Marmorkos, Meden, Molina, Molina, Molina, Molina, Nazarov, Nisikawa, Oguri, Oguri, R. A. Jalabert, Rejec, Selva, Smit, Sushkov   +30 more
core   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Thermal broadening of the Coulomb blockade peaks in quantum Hall interferometers

, 2010
We demonstrate that the differential magnetic susceptibility of a fractional quantum Hall disk, representing a Coulomb island in a Fabry--Perot interferometer, is exactly proportional to the island's conductance and its paramagnetic peaks are the ...
Cappelli A., Di Francesco P., Heinzel T., Imry Y., Kubo R., Lachezar S. Georgiev, Weymann I., Zhang Y.   +7 more
core   +1 more source

Neoadjuvant checkpoint blockade for cancer immunotherapy

Science, 2020
Presurgical immune checkpoint blockade Checkpoint blockade immunotherapy using antibodies that inhibit the programmed cell death 1 (PD-1) or cytotoxic T lymphocyte–associated protein 4 (CTLA-4) pathways has resulted in unprecedented clinical outcomes for
S. Topalian, J. Taube, D. Pardoll
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Anisotropic deformation of Rydberg blockade sphere in few-atom systems

, 2013
Rydberg blockade sphere persists an intriguing picture by which a number of collective many-body effects caused by the strong Rydberg-Rydberg interactions can be clearly understood and profoundly investigated.
Qian, Jing, Zhang, Weiping, Zhao, Xing-Dong, Zhou, Lu   +3 more
core   +1 more source

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.

New England Journal of Medicine, 2015
BACKGROUND Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 ...
S. Ansell, A. Lesokhin, I. Borrello, A. Halwani, E. Scott, M. Gutierrez, S. Schuster, M. Millenson, D. Cattry, G. Freeman, S. Rodig, B. Chapuy, A. Ligon, Lili Zhu, J. Grosso, S. Y. Kim, J. Timmerman, M. Shipp, P. Armand   +18 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source