Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
DenMerD: A Feature Propagation Enhanced Approach to Beam Blockage Correction in Weather Radar
In the realm of meteorological research, extensive global radar networks serve to detect and provide early warnings for a diverse array of weather phenomena. However, the inherently discontinuous nature of radar observations often results in the presence
Liu, Xiaodong, Sun, Jiawei, Liu, Qi
core
Do prophylactic catheter washouts reduce catheter-associated UTIs and blockage compared to standard care in adults with long-term catheters? A systematic review with meta-analysis. [PDF]
Can Urol Assoc JWong ES +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Guangtongxin yanjiuObjectiveThis study aims to address the challenge of identifying blockages in the coal gangue slurry filling pipeline by proposing a novel method based on Distributed Acoustic Sensing (DAS) and analyzing the factors influencing the accuracy of this ...
ZHU Lei +7 more
doaj
Endolymphatic duct blockage for Ménière's disease: insights from a double-blind randomised controlled trial. [PDF]
Lancet Reg Health EurAzmeh OW, Ma R, Nguyen SA.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Comparing the uplink performance of 3D and 2D antenna models in THz networks in the presence of joint human and wall blockages. [PDF]
PLoS OneAslam T, Ahmed I, Ali S.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Symptom-Specific Factors Associated With Chronic Constipation in Older Adults: Cross-Sectional Survey of Patient-Reported Outcomes. [PDF]
JMIR Form ResTakenaka M, Mitsuoka T, Sakurai H.
europepmc +1 more source