Results 211 to 220 of about 1,050,605 (265)

Development and Preliminary Validation of a Recombinant DP238L-Based Indirect ELISA for the Serological Detection of African Swine Fever Virus Antibodies. [PDF]

Vet Sci
Zhang Y, Xiao Y, Jiang Y, Wang Y, Chen J, Xiang Z, Kang C, Jin M.   +7 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

To establish an indirect ELISA method for the detection of human brucellosis based on signal peptide-truncated recombinant Cu/Zn SOD and its preliminary clinical verification. [PDF]

Front Cell Infect Microbiol
Wei C, Zhang C, Ren M, Zhang K, Yang H, Han R, Dong Z, Xie S.   +7 more
europepmc   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Mapping of C5-Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition. [PDF]

Immunology
Cooke RS, Lee KY, Menzies GE, Mizuno M, Morgan BP, Zelek WM.   +5 more
europepmc   +1 more source

Establishment of a blocking enzyme-linked immunosorbent assay based on tandem expression of dominant antigenic epitopes of the nucleocapsid protein from attenuated and virulent peste des petits ruminants virus. [PDF]

Front Cell Infect Microbiol
Zhu K, Gao X, Tong L, Du X, Chen Y, Xie J, Ren S.   +6 more
europepmc   +1 more source

A Cell-Based ELISA for High-Throughput Screening of Inhibitors Blocking Influenza Virus Attachment to the Subtype-Independent α2,6-Sialic Acid Receptor. [PDF]

Int J Mol Sci
Guo K, Wu J, Liu Y, Luo J, Jiang W, Wang C, Sheng R, Li S, Fan X, Wu Y, Xu Y, Si S, Zhang Y, Zhang J.   +13 more
europepmc   +1 more source

Evaluating novel antibodies for cytokine profiling in the guinea pig model. [PDF]

Immunohorizons
Maristela L, Longworth A, Ackart DF, Lanni F, Gibb J, Freedman A, Miller OR, Cai L, Qi H, Baldwin SL, Larsen SE, Mehaffy C, Henao-Tamayo M, Coler RN, Podell BK.   +14 more
europepmc   +1 more source

Homologous Double-Antibody Sandwich ELISA Targeting a Linear Epitope of FPV VP2 and Demonstration of Microtubule-Dependent Intracellular Trafficking. [PDF]

Microorganisms
Zhang SJ, Wang Y, Hu GY, Li JY, Lu WF, Zhang C, Pan JJ, Guo QY, Zeng L.   +8 more
europepmc   +1 more source