Results 1 to 10 of about 330,080 (279)
Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
Biology, 2023 Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur +4 more
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Cells, 2023 Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur +9 more
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Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE
Journal of Neuroinflammation, 2021 Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski +4 more
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Stem Cell Research & Therapy, 2021 Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola +14 more
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Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
Physiological Reports, 2021 Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
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Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
Fluids and Barriers of the CNS, 2019 Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge +5 more
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Research progress on perioperative blood-brain barrier damage and its potential mechanism
Frontiers in Cell and Developmental Biology, 2023 The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu +13 more
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Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Fluids and Barriers of the CNS, 2018 Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez +3 more
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Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
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