Results 1 to 10 of about 700,460 (319)

Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier [PDF]

Frontiers in Immunology, 2015
Epidemiological studies reveal an increased incidence of obesity worldwide, which is associated with increased prevalence and severity of cognitive disorders. The blood-brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the cross-talk between these two compartments.
Mauro C., De Rosa V., Marelli-Berg F., Solito E.   +3 more
openaire   +10 more sources

Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27

Biology, 2023
Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur, Océane Dusailly, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +4 more
doaj   +1 more source

Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics

Cells, 2023
Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur, Johan Hachani, Shiraz Dib, Sophie Duban-Deweer, Yannis Karamanos, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +9 more
doaj   +1 more source

Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE

Journal of Neuroinflammation, 2021
Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter   +4 more
doaj   +1 more source

RETRACTED ARTICLE: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Stem Cell Research & Therapy, 2021
Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell, Fabien Gosselet   +14 more
doaj   +1 more source

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

Physiological Reports, 2021
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
doaj   +1 more source

Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue [PDF]

Frontiers in Cellular Neuroscience, 2014
Drug biotransformation is a crucial mechanism for facilitating the elimination of chemicals from the organism and for decreasing their pharmacological activity. Published evidence suggests that brain drug metabolism may play a role in the development of adverse drug reactions and in the clinical response to drugs and xenobiotics.
José A.G. Agúndez, José A.G. Agúndez, Félix Javier eJiménez-Jiménez, Hortensia eAlonso-Navarro, Elena eGarcía-Martín, Elena eGarcía-Martín   +5 more
openaire   +3 more sources

The role of the blood–brain barrier in the development and treatment of migraine and other pain disorders [PDF]

Frontiers in Cellular Neuroscience, 2014
The function of the blood-brain barrier (BBB) related to chronic pain has been explored for its classical role in regulating the transcellular and paracellular transport, thus controlling the flow of drugs that act at the central nervous system, such as opioid analgesics (e.g., morphine) and non-steroidal anti-inflammatory drugs.
Marcos Fabio DosSantos, Marcos Fabio DosSantos, Marcos Fabio DosSantos, Rosenilde Carvalho Holanda-Afonso, Rodrigo Lopes Lima, Alexandre F DaSilva, Vivaldo eMoura-Neto, Vivaldo eMoura-Neto   +7 more
openaire   +3 more sources

In vitro Models of the Human Blood–Brain Barrier and the Impact of Efflux Transporters on Neurological Disorders: The Work of Cioni et al. (2012) [PDF]

Frontiers in Psychiatry, 2014
The blood–brain barrier (BBB) plays a fundamental role in the integrity of brain homeostasis. Acute disruption and also even slight shifting of equilibrium of structural elements or transport processes might lead to substantial consequences, resulting in neurological disorders (1).
Vogelgesang, Silke, Jedlitschky, Gabriele   +1 more
openaire   +2 more sources

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Fluids and Barriers of the CNS, 2019
Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter   +5 more
doaj   +1 more source